Training in Orthopaedic and Musculoskeletal Clinical Research

描述（由申请人提供）：肌肉骨骼和骨科疾病是非常普遍的，致残和昂贵的。然而，由于缺乏训练有素的临床和转化研究人员，对这些疾病的研究受到了阻碍。在NIAMS资助的T32项目中，只有6%的项目专注于骨科和肌肉骨骼临床和转化研究。T32培训资助的目标是为博士后候选人提供严格的临床、转化、流行病学和政策研究方面的培训，包括肌肉骨骼和骨科疾病的预防、识别、负担和影响，以及手术和非手术治疗。研究领域涵盖肌肉骨骼疾病，包括骨关节炎、骨质疏松症、骨科干预、局部疾病（如脊柱、膝关节、肩部、上肢、足/踝关节）、神经卡压、慢性肌肉骨骼疼痛和相关疾病。该项目将支持一系列学科的培训，包括流行病学、生物统计学、药物流行病学、索赔分析、决策科学、经济分析、差异检查以及社会心理和行为干预。本申请要求资助2个博士预科和3个博士后培训职位。受训者将在该项目中度过至少两年的时间。那些之前没有正式教学培训的人将获得哈佛大学公共卫生学院临床有效性项目的硕士学位。该计划提供密切的监督和机会，与来自几所哈佛医疗机构的杰出研究人员和导师组成的教师跨学科工作。教师们得到了联邦、基金会和其他方面的支持。每位教师都有成功指导的记录，每个人都领导着活跃的研究团队，从事广泛的实质性领域和方法论学科。这些机构以病人资源、庞大的电子和硬拷贝图书馆、复杂的信息系统和数据库资源的形式提供了相当大的支持。概要：这项申请寻求资金来训练年轻人成为研究肌肉骨骼和矫形问题的顶尖科学家。这些疾病非常常见、致残、昂贵且未得到充分研究。

DESCRIPTION (provided by applicant): Musculoskeletal and orthopaedic disorders are exceptionally prevalent, disabling and costly. However research on these conditions is hampered by the lack of a robust pipeline of rigorously trained clinical and translational researchers. Just 6% of NIAMS funded T32 programs have a focus in orthopaedic and musculoskeletal clinical and translational research. The objectives of this proposed T32 training grant are to provide pre- and postdoctoral candidates with a rigorous program of training in clinical, translational, epidemiological and policy research involving musculoskeletal and orthopaedic disorders, including their prevention, recognition, burden and impact, and operative and nonoperative treatment. The research areas span the musculoskeletal disorders, including osteoarthritis, osteoporosis, orthopaedic interventions, regional disorders (e.g. spine, knee, shoulder, upper extremity, foot/ankle), nerve entrapments, chronic musculoskeletal pain and related conditions. The program will support training in a range of disciplines including epidemiology, biostatistics, pharmacoepidemiology, claims analysis, decision sciences, economic analysis, examination of disparities, and psychosocial and behavioral interventions. This application requests funding for two predoctoral and three postdoctoral training positions. The trainees would spend at least two years in the program. Those without prior formal didactic training will obtain master's level education in the Clinical Effectiveness Program at Harvard School of Public Health. The Program provides close supervision and opportunities to work across disciplines with a faculty of outstanding investigators and mentors from several Harvard medical institutions. The faculty members are well funded with federal, foundation and other support. Each faculty member has a record of successful mentoring and each leads vibrant research teams engaged in a wide range of substantive areas and methodological disciplines. The institutions provide considerable support in the form of patient sources, vast electronic and hard copy libaries, sophisticated information systems and database resources. Lay summary: This application seeks funds to train young people to become leading scientists studying musculoskeletal and orthopaedic problems. These disorders are very common, disabling, expensive and understudied.