Olfactory Mechanisms Supporting Attraction to e-Cigarette Odors
支持电子烟气味吸引的嗅觉机制
基本信息
- 批准号:10464059
- 负责人:
- 金额:$ 4.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AdolescentBasal GangliaBehaviorBindingBinge EatingBrainCause of DeathComputing MethodologiesCorpus striatum structureCoupledCuesDataDecision MakingDesire for foodDopamineElectronic cigaretteElectrophysiology (science)EnvironmentEpidemicFoodFrequenciesFruitGoalsHumanInvestigationMaintenanceMeasuresMediatingMethodsMidbrain structureMissionMonitorMotivationMotorMusNational Institute on Deafness and Other Communication DisordersNational Research Service AwardsNeuromodulatorNeuronsNeurotransmittersNicotineNucleus AccumbensOdorsOlfactory tuberclePalatePathway interactionsPerceptionPharmaceutical PreparationsPharmacologyPhasePhysiologicalPositioning AttributeProcessProxyResearchRespirationRewardsRodentRoleSensorySiteSmell PerceptionSocial BehaviorStimulusStrawberriesStructureSystemTeenagersTestingTrainingTubular formationUnited StatesVentral StriatumVentral Tegmental AreaWorkbasebehavior influencecombustible cigarettecravingdopaminergic neuronelectronic cigarette useelectronic cigarette userelectronic liquidexperienceexperimental studyhedonicin vivoindexinginsightmultidisciplinarynicotine useolfactory bulboptogeneticspsychologicreceptorreinforcerrespiratoryresponsesexsocialvaping
项目摘要
PROJECT SUMMARY
Sensory information from the environment guides behavior. In particular, odors are integral to finding food,
identifying danger, and orchestrating social behaviors. Furthermore, odors can become salient cues when paired
with reinforcers which may subsequently trigger cravings (e.g., compulsive eating, drug seeking, etc). Adolescent
use of nicotine containing electronic cigarettes (e-cigarettes) has skyrocketed in recent years. Along with
nicotine, e-cigarettes often contain appealing additives, such as fruit smells, which based upon their hedonics
promote the acquisition and maintenance of e-cigarette/nicotine use in humans and rodents. Therefore, the
odors emitted from e-cigarettes are of particular importance to their sensory perception. However, the brain
systems responsible for mediating attraction to e-cigarette odors are unknown. The tubular striatum (TuS, also
known as the olfactory tubercle) is an olfactory region that also receives modulatory input from midbrain
dopaminergic (DA) neurons to inform decision-making. The TuS' distinct connectivity and dual roles in reward
and sensory processing uniquely position it to mediate attraction to e-cigarette odors. The proposed F31 NRSA
will use respiratory monitoring, behavior, site-specific pharmacology, optogenetics, and in vivo electrophysiology
to test the hypothesis that dopaminergic systems of the TuS mediate attraction to e-cigarette odors in adolescent
mice of both sexes. In Aim 1, I will test the hypothesis that DA's actions in the TuS are responsible for e-cigarette
odor attraction. In Aim 2, I will test the hypothesis that TuS neurons expressing DA 1 receptors represent e-
cigarette odors, and that their respiratory-coupled activity encodes the difference between e-cigarette odors
containing strawberry additive (attractive) versus those without (unattractive). This project will reveal olfactory
contributions to e-cigarette use and further, will uncover fundamental insights into brain systems involved in
mediating odor attraction.
项目总结
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Natalie Lewis Johnson其他文献
Natalie Lewis Johnson的其他文献
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{{ truncateString('Natalie Lewis Johnson', 18)}}的其他基金
Olfactory Mechanisms Supporting Attraction to e-Cigarette Odors
支持电子烟气味吸引的嗅觉机制
- 批准号:
10598027 - 财政年份:2022
- 资助金额:
$ 4.68万 - 项目类别:
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