Training grant on Vaccines and Immunotherapies for Infectious Diseases and Cancer

传染病和癌症疫苗和免疫疗法培训补助金

• 批准号: 10465086
• 负责人: Matthias Johannes Schnell
• 金额: $ 16.49万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10465086
• 关键词: Communicable Diseases; Grant; Immunotherapy; Malignant Neoplasms; Training; Vaccines

Summary This is a new application that proposes a training program for 3 graduate students and 2 postdoctoral fellows in vaccines and immunotherapies against microbial pathogens and cancer. The rationale for this application is to capitalize on the long-term experience of TJU in the area of vaccines, therapeutics and cancer, the need for a such a unique training opportunity in Philadelphia, and the opportunity to develop a “holistic” training experience in both basic and applied aspects of viral and tumor immunity. An important characteristic of the TPVIIDC is that the diversity of research interests of the 21 preceptors affords an opportunity to provide a comprehensive training experience that integrates basic science, vaccine development and therapeutics. Whereas there are other training programs in cancer immunology or vaccines against infectious diseases there is historically little cross-talk between these highly related research areas. We feel strongly that our program will help to provide better training by providing opportunities in different but related areas of immunology of cancer and infectious diseases. While the students and fellows will spend the majority of their time in their host laboratory, ancillary opportunities will enable interaction with a wide range of the participating faculty, facilitated by shared seminars, retreats and course offerings.

总结 这是一个新的应用程序，提出了一个培训计划，为3名研究生和2名 在疫苗和免疫疗法方面的博士后研究员对微生物病原体和癌症。 这种应用的基本原理是利用TJU在该领域的长期经验 疫苗，治疗和癌症，需要这样一个独特的培训机会， 费城，并有机会发展一个“整体”的培训经验，在基础和 病毒和肿瘤免疫的应用方面。TPVIIDC的一个重要特点是， 21位导师的研究兴趣各不相同， 综合培训经验，将基础科学、疫苗开发和 治疗学尽管有其他癌症免疫学或疫苗的培训项目， 对抗传染病，历史上这些高度相关的 研究领域。我们强烈认为，我们的计划将有助于提供更好的培训， 在不同但相关的癌症和传染病免疫学领域提供机会 疾病而学生和研究员将花大部分时间在他们的主机 实验室，辅助机会将使互动与广泛的参与 教师，通过共享研讨会，务虚会和课程提供便利。

项目成果

Oral D-mannose treatment suppresses experimental autoimmune encephalomyelitis via induction of regulatory T cells.

• DOI: 10.1016/j.jneuroim.2021.577778
• 发表时间: 2022-01-15
• 期刊: Journal of neuroimmunology
• 影响因子: 3.3
• 作者: Hwang D;Boehm A;Rostami A;Zhang GX;Ciric B
• 通讯作者: Ciric B

CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.

• DOI: 10.1073/pnas.2111804119
• 发表时间: 2022-04-05
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

GATA1 controls numbers of hematopoietic progenitors and their response to autoimmune neuroinflammation.

• DOI: 10.1182/bloodadvances.2022008234
• 发表时间: 2022-12-13
• 期刊: BLOOD ADVANCES
• 影响因子: 7.5
• 作者: Hwang, Daniel;Ishikawa, Larissa Lumi Watanabe;Seyedsadr, Maryam S.;Mari, Elisabeth;Kasimoglu, Ezgi;Sahin, Ziver;Boehm, Alexandra;Jang, Soohwa;Rasouli, Javad;Vaccaro, Courtney;Gonzalez, Michael;Hakonarson, Hakon;Rostami, Abdolmohamad;Zhang, Guang-Xian;Ciric, Bogoljub
• 通讯作者: Ciric, Bogoljub