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中文摘要
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机会基金管理核心(OFMC)的总体目标是促进早期阶段 支持创新、探索和研发项目,特别是那些有可能导致 辐射生物剂量学和预测及预防急性和迟发性 受伤OFMC将支持1)试点项目(基础和转化研究)和2)高级 开发项目,导致试验性新药(IND)-使能研究和医疗 反制措施(MCM)的发展。 OFMC将为核心的运行制定SOP(标准操作程序), 指导委员会的批准,将成为其运作的模板。OFMC将协调以下过程: 征求建议,并协调外部专家小组对建议的审查 为此目的召开了电话会议。OFMC将对审查小组在 电话会议,并提交排名排序的名单,以指导委员会的资金决定。 创新和转化研究将在审查过程中得到大力强调。OFMC将 我还负责协调财务、IRB和IACUC要求的所有必要文件 与次级受援机构的合作以及财务监督和报告。OFMC还将协调 年度进度报告,并收集进度报告和更新请求,供指导委员会审议 以马克思OFMC还将帮助为试点项目接受者提供介绍机会。为 例如,试点获奖者可能有机会为年度CMCRC会议准备海报,以及 将被鼓励出席国家会议,如辐射研究学会年会。 !
英文摘要
The broad objective of the Opportunities Fund Management Core (OFMC) will be to facilitate early stage support for innovative, exploratory, and R&D projects, particularly those which have the potential to lead to practical products in the fields of radiation biodosimetry and prediction and prevention of acute and delayed injuries. The OFMC will support 1) Pilot projects (basic and translational research) and 2) Advanced Development projects that lead to Investigational New Drug (IND)-enabling studies and Medical Countermeasure (MCM) development. The OFMC will generate an SOP (Standard Operating Procedure) for the operation of the Core, which after Steering Committee approval, will be the template for its operation. The OFMC will coordinate the process of soliciting proposals, as well as coordinating the review of the proposals by an external panel of experts convened via teleconference for the purpose. The OFMC will tally the scores given by the review panel at the teleconference, and present the rank ordered list to the Steering Committee for funding decisions. Innovative and translational research will be strongly emphasized in the review process. The OFMC will also be responsible for coordinating all necessary documentation of financial, IRB, and IACUC requirements with sub-recipient institutions, as well as financial oversight and reporting. The OFMC will also coordinate annual progress reports, and collect progress reports with renewal requests to be considered by the Steering Committee. The OFMC will also help to facilitate Presentation opportunities for the pilot project recipients. For instance, pilot awardees may be given the opportunity to prepare a poster for the annual CMCRC meeting, and will be encouraged to present at national meetings, such as the Radiation Research Society Annual Meeting. !
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Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
Radiation Biodosimetry Using Gene Expression Signatures
Opportunities Fund Management Core
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