Opportunities Fund Management Core

机遇基金管理核心(OFMC)的广泛目标将是促进早期阶段 支持创新或转化性项目，特别是那些有可能带来实际成果的项目 辐射生物剂量测定以及急性和延迟性损伤的预测和预防领域的产品。这个 OFMC将支持1)试点项目(基础和翻译研究)和2)导致 研究性新药(IND)-使能研究和医学对策(MCM)开发。 OFMC将为核心的运行生成SOP(标准操作程序)，之后 指导委员会的批准，将成为其运作的模板。 这一过程的核心是向OFMC提供可能的最佳应用程序集，OFMC将使用 独特的基于导师的两阶段审查计划；第一阶段是强制性的建议书前意向书 来自潜在申请者的。这使得OFMC能够将申请者与合适的CMCRC科学家配对，以 创造指导/建议机会，从而产生与CMCRC一致的更强有力的全面建议 问题和目标。第二阶段将在六周后提交完整的提案。通讯及通讯中心 将协调征求意向书和后续提案的进程，并协调 对提案进行审查，最后向CMCRC指导委员会提供一套审查分数。 将大力强调创新和转化性研究以及新的或早期的调查人员 在审查过程中。 OFMC还将负责协调所有必要的财务、IRB和 IACUC对次级受援机构的要求，以及财务监督和报告。电信管理公司将 还将协调年度进展报告，并将根据这些报告提出延长资金的建议，以 指导委员会。 重要的是，电信管理公司将为试点项目获得者提供介绍机会。所有飞行员 获奖者将被要求为CMCRC年度会议准备一张海报。带着方向盘 委员会的批准，并根据这些海报，通讯管理委员会将与协调中心合作，建议和 在CMCRC年会上为试点获奖者组织一次海报小型演示会议。

The broad objective of the Opportunities Fund Management Core (OFMC) will be to facilitate early stage support for innovative or translational projects, particularly those which have the potential to lead to practical products in the fields of radiation biodosimetry and prediction and prevention of acute and delayed injuries. The OFMC will support 1) Pilot projects (basic and translational research) and 2) proposals that lead to Investigational New Drug (IND)-enabling studies and Medical Countermeasure (MCM) development. The OFMC will generate an SOP (Standard Operating Procedure) for the operation of the Core which, after Steering Committee approval, will be the template for its operation. Central to the process is getting the best possible set of applications to the OFMC, and the OFMC will use a unique two-phase mentor-based review program; The first phase is a mandatory pre-proposal Letter of Intent from potential applicants. This enables the OFMC to pair applicants with appropriate CMCRC scientists to create mentoring/advising opportunities that lead to stronger full proposals that are in tune with CMCRC issues and goals. The second phase, due six weeks later, is the submission of the full proposal. The OFMC will coordinate the process of soliciting Letters of Intent and subsequent Proposals, as well as coordinating the review of the proposals, and finally providing a set of review scores to the CMCRC Steering Committee. Innovative and translational research, as well as New or Early Stage Investigators, will be strongly emphasized in the review process. The OFMC will also be responsible for coordinating all necessary documentation of financial, IRB, and IACUC requirements with subrecipient institutions, as well as financial oversight and reporting. The OFMC will also coordinate annual progress reports, and based on these, will make funding renewal recommendations to the Steering Committee. Importantly, the OFMC will facilitate presentation opportunities for the pilot project recipients. All pilot awardees will be requested to prepare a poster for the annual CMCRC meeting. With the Steering Committee's approval, and based on these posters, the OFMC, in collaboration with the CCC, will propose and organize a poster mini-presentation session for pilot awardees at the CMCRC Annual Meeting.