FASEB SRC: The Post-transcriptional Control of Gene Expression Conference: Mechanisms of RNA Decay

项目总结 人们对RNA降解对基因表达至关重要的认识可以追溯到1959年，当时帕迪、雅各布 莫诺德在一篇历史论文中证明，一定存在一种不稳定的中间引导蛋白质 综合。最近，引人注目的使用RNA干扰实验降解特定的mRNAs 已经扩展了对RNA衰变机制的理解，这超出了人们的预期。临床部 转录后调控/RNA领域的应用才刚刚开始实现 成功治疗脊髓性肌萎缩的Nusinesen/Spinraza®的开发及最新进展 描述MILASIN®通过个性化RNA疗法治疗单个患者。当然，在2019年末进入 2020年初，核糖核酸以一种我们无法用新冠肺炎核糖核酸病毒预测的方式登上全球舞台 影响着我们所知的世界各地的生命。谁会或可能会猜到RNA也能代表 通过快速开发和部署第一批信使核糖核酸疫苗，一条回到新常态的潜在途径。全 这些例子中的一个突出了为什么FASE B关于‘转录后基因表达调控： 《RNA衰变机制》是在这个节骨眼上支持的这样一个及时的会议。这次会议已经发展到 成为一个独特的会议，汇聚了人类和其他后生动物的RNA衰变方面的领先专家 动物、植物、真菌、病毒和细菌。本次会议是FASEB就这一主题举行的第12次系列会议 在那里，分享关键发现、建立合作和为事业做出贡献的传统由来已久 该领域初级科学家的发展。这次会议，在由于全球事务而推迟了两年之后 大流行，将于2022年6月19日至23日在佛罗里达州的朱庇特举行，目前正在由RNA的三位领导人共同组织 来自美国埃默里的Anita H.Corbett博士、英国剑桥MRC的Lori Passmore博士和Dr。 塞西莉亚·阿拉亚诺来自葡萄牙新里斯本大学ITQB。在这个领导下，我们建议 三个具体目标：1)将RNA降解领域汇聚在一起，并为演讲和 讨论最新进展；2)提供一个包容各方的环境，以便在 研究人员用不同的方法在不同的生物体中研究RNA的降解；以及3)鼓励 在RNA降解方面，初级科学家和领导者之间的不同群体之间的有效互动 菲尔德。为了与会议目标和组织者的共同激情保持一致，本次会议以 对包容性卓越的重大承诺。到目前为止，在35位受邀演讲者中，有18位女性(51%) 男性17人(49%)。每期会议由一名资深科学家和一名初级科学家组成的联合主席团队主持。 科学家。在18位联席主席中，有11位(61%)是女性。我们很高兴有五位联席主席，他们来自 传统上在STEM领域代表性不足的群体(28%)。我们的长期目标是继续成功地 会议系列，讨论现代和及时的RNA衰变和处理主题，同时建立不同的 合作的科学家和同事的包容性社区。

PROJECT SUMMARY The understanding that RNA degradation is critical for gene expression traces back to 1959 when Pardee, Jacob and Monod demonstrated in a historical paper that there had to be an unstable intermediate directing protein synthesis. More recently, the spectacular use of RNA interference to experimentally degrade specific mRNAs has expanded the applications of understanding RNA decay mechanisms beyond any expectations. The clinical applications in the post-transcriptional regulation/RNA field are only starting to be realized with the initial development of Nusinersen/Spinraza® to successfully treat Spinal Muscular Atrophy and the more recent description of Milasin® to treat a single patient through a personalized RNA therapy. Of course in late 2019 into early 2020, RNA burst on to the global stage in a way we could not have predicted with the COVID-19 RNA virus impacting life as we know it across the globe. Who would or could have guessed that RNA could also represent a potential path back to a new normal via the rapid development and deployment of the first mRNA vaccines. All of these examples highlight why The FASEB meeting on ‘Post-transcriptional Regulation of Gene Expression: Mechanisms of RNA Decay’ is such a timely conference to support at this juncture. This meeting has developed into a unique conference that brings together the leading experts in RNA decay in humans and other metazoan animals, plants, fungi, viruses, and bacteria. This meeting is the 12th is a series of FASEB meetings on this topic where there is a long tradition of sharing key discoveries, building collaborations, and contributing to career development for junior scientists in the field. This meeting, which, after a two year delay due to the global pandemic, will be held June 19-23, 2022 in Jupiter, Florida, is being co-organized by three leaders in the RNA decay field, Dr. Anita H. Corbett from Emory, USA, Dr. Lori Passmore from the MRC in Cambridge UK, and Dr. Cecilia Arraiano from the ITQB/Universidade NOVA de Lisboa, Portugal. Under this leadership, we propose three specific aims: 1) Bring together the RNA degradation field and provide a forum for the presentation and discussion of the latest advances; 2) Provide an inclusive environment for establishing collaborations between researchers studying RNA degradation with different approaches and in different organisms; and 3) Encourage productive interactions between a diverse group of both junior scientists and leaders in the RNA degradation field. In keeping with a meeting goal and a common passion of the organizers, this meeting is organized with a major commitment to inclusive excellence. Among the 35 invited speakers thus far, there are 18 women (51%) and 17 men (49%). Each session is chaired by a co-chair team consisting of a senior scientist and a junior scientist. Among the 18 co-chairs, 11 (61%) are women. We are excited to include five co-chairs who are from groups traditionally underrepresented in STEM fields (28%). The long-term goal is to continue a successful meeting series that addresses modern and timely topics in RNA decay and processing while building a diverse and inclusive community of collaborative scientists and colleagues.