FASEB SRC: The Post-transcriptional Control of Gene Expression Conference: Mechanisms of RNA Decay

项目摘要 RNA降解对基因表达至关重要的认识可以追溯到1959年，当时Pardee，Jacob 莫诺在一篇历史论文中证明， 合成.最近，RNA干扰在实验上降解特定mRNA的惊人应用 已经超出预期地扩展了理解RNA衰变机制的应用。临床 在转录后调控/RNA领域的应用只是开始实现与最初的 开发Nusinersen/Spinraza®成功治疗脊髓性肌萎缩症，以及最近 本发明涉及Milasin®通过个性化RNA疗法治疗单个患者的描述。当然，在2019年底， 2020年初，RNA以我们无法预测的COVID-19 RNA病毒的方式登上了全球舞台 影响着地球仪上的生命。谁会或可能猜到RNA也可以代表 通过第一批mRNA疫苗的快速开发和部署，这是一条回到新常态的潜在途径。所有 这些例子强调了为什么FASEB会议上的“基因表达的转录后调节： RNA衰变的机制'是这样一个及时的会议，以支持在这个时刻。这次会议发展了 成为一个独特的会议，汇集了在人类和其他后生动物的RNA衰变的领先专家 动物、植物、真菌、病毒和细菌。本次会议是第12次，是FASEB关于这一主题的一系列会议 在那里，有着分享关键发现、建立合作和为职业生涯做出贡献的悠久传统。 为该领域的年轻科学家提供发展机会。这次会议，其中，经过两年的拖延，由于全球 大流行，将于2022年6月19日至23日在佛罗里达的朱庇特举行，由RNA的三位领导人共同组织 衰变场，安妮塔·H.来自美国埃默里的Corbett博士，来自英国剑桥MRC的洛里帕斯莫尔博士，以及来自英国剑桥大学医学研究中心的Dr. Cecilia Arraiano来自ITQB/Universidade NOVA de Lisboa，葡萄牙。在这一领导下，我们建议 三个具体目标：1）汇集RNA降解领域，并提供一个论坛的介绍， 讨论最新进展; 2）提供一个包容性的环境， 研究人员用不同的方法和在不同的生物体中研究RNA降解;和3）鼓励 在RNA降解的初级科学家和领导者的不同群体之间的富有成效的互动 领域为了与会议目标和组织者的共同热情保持一致，本次会议以 致力于包容性卓越。迄今为止，在35名受邀发言者中，有18名妇女（51%） 和17名男性（49%）。每次会议由一个由一名资深科学家和一名初级科学家组成的联合主席小组主持。 科学家在18名共同主席中，有11名（61%）是妇女。我们很高兴邀请到五位来自 传统上在STEM领域代表性不足的群体（28%）。长期目标是继续成功的 会议系列，解决RNA衰变和加工的现代和及时的主题，同时建立一个多样化的 和包容性的协作科学家和同事的社区。

PROJECT SUMMARY The understanding that RNA degradation is critical for gene expression traces back to 1959 when Pardee, Jacob and Monod demonstrated in a historical paper that there had to be an unstable intermediate directing protein synthesis. More recently, the spectacular use of RNA interference to experimentally degrade specific mRNAs has expanded the applications of understanding RNA decay mechanisms beyond any expectations. The clinical applications in the post-transcriptional regulation/RNA field are only starting to be realized with the initial development of Nusinersen/Spinraza® to successfully treat Spinal Muscular Atrophy and the more recent description of Milasin® to treat a single patient through a personalized RNA therapy. Of course in late 2019 into early 2020, RNA burst on to the global stage in a way we could not have predicted with the COVID-19 RNA virus impacting life as we know it across the globe. Who would or could have guessed that RNA could also represent a potential path back to a new normal via the rapid development and deployment of the first mRNA vaccines. All of these examples highlight why The FASEB meeting on ‘Post-transcriptional Regulation of Gene Expression: Mechanisms of RNA Decay’ is such a timely conference to support at this juncture. This meeting has developed into a unique conference that brings together the leading experts in RNA decay in humans and other metazoan animals, plants, fungi, viruses, and bacteria. This meeting is the 12th is a series of FASEB meetings on this topic where there is a long tradition of sharing key discoveries, building collaborations, and contributing to career development for junior scientists in the field. This meeting, which, after a two year delay due to the global pandemic, will be held June 19-23, 2022 in Jupiter, Florida, is being co-organized by three leaders in the RNA decay field, Dr. Anita H. Corbett from Emory, USA, Dr. Lori Passmore from the MRC in Cambridge UK, and Dr. Cecilia Arraiano from the ITQB/Universidade NOVA de Lisboa, Portugal. Under this leadership, we propose three specific aims: 1) Bring together the RNA degradation field and provide a forum for the presentation and discussion of the latest advances; 2) Provide an inclusive environment for establishing collaborations between researchers studying RNA degradation with different approaches and in different organisms; and 3) Encourage productive interactions between a diverse group of both junior scientists and leaders in the RNA degradation field. In keeping with a meeting goal and a common passion of the organizers, this meeting is organized with a major commitment to inclusive excellence. Among the 35 invited speakers thus far, there are 18 women (51%) and 17 men (49%). Each session is chaired by a co-chair team consisting of a senior scientist and a junior scientist. Among the 18 co-chairs, 11 (61%) are women. We are excited to include five co-chairs who are from groups traditionally underrepresented in STEM fields (28%). The long-term goal is to continue a successful meeting series that addresses modern and timely topics in RNA decay and processing while building a diverse and inclusive community of collaborative scientists and colleagues.