Data and Omics Sciences Core (DATAOmics)

数据和OMICS科学核心(DATAOmics) 项目摘要/摘要 数据和OMICS核心(DATAOMICS)的主要目标是协助 感染驱动的恶性肿瘤促进职业和翻译科学计划(IMPACT)，一种癌症 波多黎各大学(UPR)和MD安德森癌症中心之间的研究伙伴关系 (MDACC)，通过加强基础设施来支持Impact的研究、教育和推广 在定量分析和科学报告方面的活动。我们建议扩大和加强 IMPACT和UPR综合癌症中心之间的关系，通过建立一个正式单位来 在以下领域支持他们的研究人员和参与者(本科生和研究生) 生物统计学、流行病学、生物信息学和OMICS科学。DATAOmics功能将得到增强， 在至少两个方面尊重以前的生物统计学、流行病学和生物信息学核心(BEBIC)：1) 纳入一名在欧米奇科学方面具有实验和分析专长的新调查员， 特别是在下一代测序和质谱学方面，以及在潮湿的实验室经验中， 这在现代癌症研究中是至关重要的，特别是对于完整的项目A和试点 项目A；和2)向DATAOmics添加一台小型且完全专用的计算机服务器，这将增强 我们承担现实生物信息学和Omics问题的计算能力，并将使参与者能够 接受生物信息学分析方面的培训。DATAOmics的总体目标是提高 Impact的研究项目通过提供高质量和及时的生物统计、数据科学、 生物信息学和Omics在研究的所有阶段提供咨询和咨询。DATAOmics的具体目标 1)提供研究设计、数据收集和管理、统计等方面的支持和咨询 对所有研究项目进行分析；2)提高设计和统计分析方面的癌症研究能力 生物统计学、数据科学、生物信息学和OMICS 参与者；以及3)开发和应用创新的生物统计学和生物信息学方法来研究癌症 由我们的研究人员发起的研究项目。DATAOmics将包括两个组成部分：1)生物统计学和 数据科学，以及2)生物信息学和欧姆组学。生物统计和数据科学部分，网址为 普遍定期审议将有两名统计员和一名流行病学家专门从事方法和统计方面的工作。 研究项目的最新进展。MDACC将聘用一名高级生物统计师和一名高级数据分析师。这个 UPR的生物信息学和OMICS科学部门将有两名生物信息学家从事 广义项目的生物信息学方面(包括：基因组学、转录组学、 药物基因组学、蛋白质组学、表观基因组学、代谢组学、脂类组学和微生物组学)，以及MDACC将 分配一名高级生物信息学家。

DATA AND OMICS SCIENCES CORE (DATAOmics) PROJECT SUMMARY/ABSTRACT The primary objective of the Data and Omics Sciences Core (DATAOmics) is to assist the work of the Infection-Driven Malignancies Program for Advancing Careers and Translational Sciences (IMPACT), a cancer research partnership between the University of Puerto Rico (UPR) and the MD Anderson Cancer Center (MDACC), through an enhanced infrastructure to support IMPACT's research, education, and outreach activities, in quantitative analyses and scientific reporting. We propose to expand and strengthen the relationships between IMPACT and the UPR Comprehensive Cancer Center by establishing a formal unit to support their researchers and participants (undergraduate and graduate students) in areas such as biostatistics, epidemiology, bioinformatics and Omics sciences. DATAOmics capabilities will be enhanced, with respect to the previous Biostatistics, Epidemiology and Bioinformatics Core (BEBiC) in at least two ways: 1) the incorporation of a new investigator with experimental and analytical expertise in Omics sciences, particularly in next generation sequencing and mass spectrometry, and with wet lab experience, a dimension which is now of paramount importance in modern cancer research, particularly for Full Project A and Pilot Project A; and 2) by adding a small and fully dedicated computer server to DATAOmics, which will enhance our computational ability to undertake realistic bioinformatics and Omics problems and will enable participants to be trained in bioinformatics analyses. The overall goal of DATAOmics is to enhance the productivity of IMPACT's research projects through the provision of high-quality and timely biostatistics, data sciences, bioinformatics and Omics advice and consultancy at all stages of research. The specific aims of DATAOmics are: 1) Provide support and consulting on study design, data gathering and management, and statistical analysis to all research projects; 2) Increase cancer research capacity in design and statistical analyses in biostatistics, data sciences, bioinformatics and Omics through educational activities for our researchers and participants; and 3) Develop and apply innovative biostatistics and bioinformatics methodologies to the cancer research projects initiated by our researchers. DATAOmics will include two components: 1) Biostatistics and Data Science, and 2) Bioinformatics and Omics Sciences. The Biostatistics and Data Science component at UPR will have two statisticians and one epidemiologist dedicated to the methodological and statistical aspects of the research projects. MDACC will engage one senior biostatistician and one senior data analyst. The Bioinformatics and Omics Sciences components at UPR will have two bioinformaticians engaged in the bioinformatics facets of the projects in a broad sense (including: genomics, transcriptomics, pharmacogenomics, proteomics, epigenomics, metabolomics, lipidomics, and microbiomics), and MDACC will allocate one senior bioinformatician.