Core 3: Biostatistics, Data Management, and Bioinformatics

项目摘要 生物统计和生物信息学核心（核心3）的主要目标是提供集中的生物统计， 生物信息学和数据库支持所有项目和核心。核心3将提供设计指导， 进行临床试验和其他实验，这些实验是由SPORE正在进行的研究引起的， 前瞻性收集、录入、质量控制和整合基础科学、临床前和 临床研究，并提供高通量和高维基因组学的生物信息学数据分析 数据我们将提供创新和定制的统计建模，模拟技术和数据分析， 主要项目，发展研究和职业提升项目，以及其他核心，以实现其 明确的目标。我们将进行数据分析，并准备所有实验的统计报告， 项目，确保所有项目的结果得到适当的解释，并协助所有项目调查员 发表科学成果。Core 3也将成为SPORE内部和内部协作的资源， 包括研究设计和开发多中心临床试验数据库。

Project Summary The major objective of the Biostatistics and Bioinformatics Core (Core 3) is to provide centralized biostatistics, bioinformatics, and database support for all Projects and Cores. Core 3 will provide guidance in the design and conduct of clinical trials and other experiments that arise from the ongoing research of the SPORE, facilitate prospective collection, entry, quality control, and integration of data for the basic science, pre-clinical, and clinical studies, and provide bioinformatics data analysis of high-throughput and high-dimensional genomics data. We will provide innovative and tailored statistical modeling, simulation techniques, and data analyses for the main projects, developmental research and career enhancement projects, and other cores to achieve their specific aims. We will conduct data analyses and prepare statistical reports for all experiments within all projects, ensure that the results of all projects are appropriately interpreted, and assist all project investigators in the publication of scientific results. Core 3 will also be a resource for intra- and inter-SPORE collaborations, including study design and developing databases for multi-center clinical trials.