DEVELOPMENT OF RABBIT MONOCLONAL ANTIBODIES FOR FERRET BIOMARKERS
DEVELOPMENT OF RABBIT MONOCLONAL ANTIBODIES FOR FERRET BIOMARKERS
批准号:
10470554
负责人:
XIAOMIN FAN
金额:
$35.6万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-08-01 至 2023-07-31
关键词:
AddressAntibodiesBiological AssayBiological MarkersEnzyme-Linked Immunosorbent AssayFerretsIL8 geneImmunizationImmunologicsImmunology procedureInfectious Disease ImmunologyInflammatoryInterferon Type IIInterleukin-1Interleukin-18MeasuresMonoclonal AntibodiesOryctolagus cuniculusReagentResearchTNF geneYeastscytokineimmune activationinfectious disease modelreceptorresponse
中文摘要
本项目旨在制备和鉴定针对五种雪貂生物标志物的兔单克隆抗体(mab),重点研究雪貂免疫激活后产生的炎症细胞因子。生成的单克隆抗体将进行广泛的免疫学表征。该项目的成功完成将解决对能够测量雪貂模型中细胞因子反应的特异性和敏感性试剂的迫切需求,用于传染病和免疫学研究。
英文摘要
This project is to generate and characterize rabbit monoclonal antibodies (mAbs) against five ferret biomarkers, focusing on inflammatory cytokines produced following immune activation in ferrets. Generated mAbs will undergo extensive immunological characterization. The successful completion of this project will address an urgent need for specific and sensitive reagents capable of measuring cytokine responses in the ferret model for infectious disease and immunology research.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Development and validation of anti-canine reagents to enable pre-clinical development of novel therapeutics
-
批准号:10267452
-
项目类别:
-
资助金额:$199.59万
-
财政年份:2020
-
负责人:XIAOMIN FAN
-
依托单位:
IGF::OT::IGF Topic 372 - SBIR Phase I: Development and Validation of Non- Mouse Reagents to Enable Preclinical Development of Novel Therapeutics - Moonshot
-
批准号:9795158
-
项目类别:
-
资助金额:$29.99万
-
财政年份:2018
-
负责人:XIAOMIN FAN
-
依托单位:
Developing a highly specific and sensitive glucagon ELISA kit
-
批准号:8974749
-
项目类别:
-
资助金额:$22.47万
-
财政年份:2015
-
负责人:XIAOMIN FAN
-
依托单位:
Novel platform for isolation of rabbit monoclonal antibodies against modified RNA bases
-
批准号:8841274
-
项目类别:
-
资助金额:$18.81万
-
财政年份:2014
-
负责人:XIAOMIN FAN
-
依托单位:
TOPIC 319 PHASE I; RECOMBINANT RABBIT MONOCLONAL ANTIBODIES AS AFFINITY CAPTURES
-
批准号:8762826
-
项目类别:
-
资助金额:$20.0万
-
财政年份:2013
-
负责人:XIAOMIN FAN
-
依托单位:
OTHER FUNCTIONS - RECOMBINANT ANTIBODIES AS AFFINITY CAPTURES
-
批准号:8564131
-
项目类别:
-
资助金额:$99.08万
-
财政年份:2012
-
负责人:XIAOMIN FAN
-
依托单位:
A novel approach for developing GPCR subtype specific antibodies
-
批准号:8198932
-
项目类别:
-
资助金额:$34.97万
-
财政年份:2011
-
负责人:XIAOMIN FAN
-
依托单位:
A novel approach for developing GPCR subtype specific antibodies
-
批准号:8330248
-
项目类别:
-
资助金额:$34.2万
-
财政年份:2011
-
负责人:XIAOMIN FAN
-
依托单位:
TAS::75 0893::TAS RENEWABLE CAPTURES FOR ADDICTION-RELEVANT PROTEINS
-
批准号:8432390
-
项目类别:
-
资助金额:$1.45万
-
财政年份:2010
-
负责人:XIAOMIN FAN
-
依托单位:
TAS::75 0893::TAS RENEWABLE CAPTURES FOR ADDICTION-RELEVANT PROTEINS
-
批准号:8164231
-
项目类别:
-
资助金额:$75.0万
-
财政年份:2010
-
负责人:XIAOMIN FAN
-
依托单位:
TAS::75 0849::TAS DEVELOPMENT OF ALTERNATIVE AFFINITY CAPTURE REAGENTS FOR CANCE
-
批准号:8165621
-
项目类别:
-
资助金额:$15.0万
-
财政年份:2010
-
负责人:XIAOMIN FAN
-
依托单位:
TAS::75 0872::TAS RECOMBINANT ANTIBODIES AS AFFINITY CAPTURES
-
批准号:8175617
-
项目类别:
-
资助金额:$15.0万
-
财政年份:2010
-
负责人:XIAOMIN FAN
-
依托单位:
Novel human anti-uPAR antibodies for the treatment of pancreatic cancer
-
批准号:7670635
-
项目类别:
-
资助金额:$15.8万
-
财政年份:2009
-
负责人:XIAOMIN FAN
-
依托单位:
A novel therapeutic antibody for treatment of ischemic stroke.
-
批准号:7480561
-
项目类别:
-
资助金额:$22.01万
-
财政年份:2008
-
负责人:XIAOMIN FAN
-
依托单位:
海外基金