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DEVELOPMENT OF RABBIT MONOCLONAL ANTIBODIES FOR FERRET BIOMARKERS

DEVELOPMENT OF RABBIT MONOCLONAL ANTIBODIES FOR FERRET BIOMARKERS
雪貂生物标志物兔单克隆抗体的开发
批准号:
10470554
负责人:
XIAOMIN FAN
金额:
$35.6万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-08-01 至 2023-07-31

项目摘要

项目成果

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中文摘要
翻译
本项目旨在制备和鉴定针对五种雪貂生物标志物的兔单克隆抗体(mab),重点研究雪貂免疫激活后产生的炎症细胞因子。生成的单克隆抗体将进行广泛的免疫学表征。该项目的成功完成将解决对能够测量雪貂模型中细胞因子反应的特异性和敏感性试剂的迫切需求,用于传染病和免疫学研究。
英文摘要
This project is to generate and characterize rabbit monoclonal antibodies (mAbs) against five ferret biomarkers, focusing on inflammatory cytokines produced following immune activation in ferrets. Generated mAbs will undergo extensive immunological characterization. The successful completion of this project will address an urgent need for specific and sensitive reagents capable of measuring cytokine responses in the ferret model for infectious disease and immunology research.
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