MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) COORDINATING CENTER (CC) - TASK AREA B EXAM 7

多民族动脉粥样硬化研究 (MESA) 协调中心 (CC) - 任务领域 B 考试 7

• 批准号: 10470548
• 负责人: ROBYN MCCLELLAND
• 金额: $ 175.6万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-19 至 2026-12-18
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470548
• 关键词: Abdomen; Address; Adverse event; African American; Albumins; Ankle; Area; Atherosclerosis; Biological; Blood; Cardiac; Cardiovascular Diseases; Chinese People; Cholesterol; Clinical; Code; Collection; Communities; Creatinine; Data; Data Collection; Disease; Event; Glucose; Glycosylated hemoglobin A; High Density Lipoproteins; Hispanics; Hospitalization; Informed Consent; Injury; Laboratories; Lipids; Magnetic Resonance Imaging; Manuals; Measurement; Measures; Mediating; Multi-Ethnic Study of Atherosclerosis; Online Systems; Participant; Photography; Protocols documentation; Reporting; Retina; Sampling; Services; Shipping; Ships; Standardization; System; Testing; Training; Translations; Triglycerides; Ultrasonography; Urine; Vital Status; Woman; X-Ray Computed Tomography; aged; base; biobank; brachial artery; clinical development; cohort; data exchange; follow-up; indexing; member; men; operation; population based; radial artery; recruit; residence; tonometry; urinary; web-enabled

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the predictors and progression of subclinical cardiovascular disease (CVD), and the relationship of subclinical disease and its’ progression with clinical CVD in a population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. 6,814 participants who identified themselves as White (38%), African-American (28%), Hispanic (22%), or Chinese (12%) were recruited from six U.S. communities from 2000-2002. Participants were examined for evidence of subclinical atherosclerosis using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography, and, in subsets, carotid MRI, abdominal aortic CT, and other measures. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years. Participation of the surviving cohort was 92, 89, 87, 78, and 68 percent at each of the respective follow-up examinations. Cohort members have been contacted every 9-12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical CVD events. Cohort retention was 86% at the last completed follow-up ending on August 14, 2020. The wealth of data and biological samples collected since MESA’s inception as well as the potential for new data collection from MESA participants offer vast opportunities for new scientific discoveries. Task Area 2 will leverage data and samples amassed in MESA to address new questions about the development of clinical CVD. A limited examination of the cohort will be conducted during 2021-2023. An estimated 3000 participants will be examined.

多种族动脉粥样硬化研究（梅萨）是一项研究亚临床心血管疾病（CVD）的预测因素和进展，以及亚临床疾病及其进展与临床CVD的关系，研究对象为45-84岁的男性和女性，基线时无临床CVD证据。从2000年到2002年，从美国六个社区招募了6,814名参与者，他们认为自己是白色（38%），非洲裔美国人（28%），西班牙裔（22%）或中国人（12%）。 通过计算机断层扫描、心脏MRI、颈动脉超声、血流介导的肱动脉扩张、桡动脉张力测定、踝肱指数测量和视网膜摄影，以及颈动脉MRI、腹主动脉CT和其他测量方法，对参与者进行亚临床动脉粥样硬化证据检查。在随后的五次检查中重复了选定组件的检查，时间跨度约为16年。在每次随访检查中，存活队列的参与率分别为92%、89%、87%、78%和68%。每9-12个月联系一次队列成员，以获得有关生命状态、当前居住地、重大疾病或损伤以及接触之间发生的住院情况的信息，以确定临床CVD事件。在2020年8月14日末次完成随访时，队列保留率为86%。 自梅萨成立以来收集的大量数据和生物样本以及从梅萨参与者收集新数据的潜力为新的科学发现提供了巨大的机会。任务领域2将利用梅萨积累的数据和样本来解决有关临床CVD发展的新问题。将在2021-2023年期间对该队列进行有限的检查。预计将有3000名参与者接受检查。