The biophysics and potential cell-type selectivity of acoustic neuromodulation

摘要 神经科学对大规模扰动工具有一个基本要求。是这样的 工具将在大脑功能的映射、因果测试中起到革命性的作用 神经学模型，以及神经疾病的诊断和治疗。这个 拟议的五年计划旨在揭示美国的基本机制 通过数学分析、计算建模和 实验验证。使用之前开发的预测模型作为脚手架，我们将 建立一个完整的解释理论来解释美国对小鼠的刺激效应，包括细胞类型特异性 这种扰动模式的影响。我们将探索美国变量的大参数空间， 包括时空动力学和占空比调制，同时敏感的双光子 将使用功能成像度量来测量这些参数的生物物理影响 在活体大脑皮质、丘脑和海马区的神经反应。

Summary Neuroscience has an essential requirement for large-scale perturbation tools. Such tools would be transformative in the mapping of brain function, the causal testing of neurotheoretic models, and the diagnosis and treatment of neurological disorders. The proposed five-year project is aimed at uncovering the fundamental mechanisms of US stimulation through the reciprocity of mathematical analysis, computational modeling and experimental validation. Using a previously developed predicative model as a scaffold, we will build a full explanatory theory of US stimulation effects in mice, including cell-type specific effects of this perturbation modality. A large parameter space of US variables will be explored, including spatiotemporal dynamics and duty cycle modulation, while sensitive two-photon functional imaging metrics will be used to measure the biophysical impact of these parameters on neural responses in the cortex, thalamus, and hippocampus in vivo.