The biophysics and potential cell-type selectivity of acoustic neuromodulation

声神经调节的生物物理学和潜在的细胞类型选择性

• 批准号: 10469915
• 负责人: Robert Crooks Froemke
• 金额: $ 16.95万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469915
• 关键词: Acoustics; Anatomy; Attention; Behavioral; Biophysics; Brain; Brain Mapping; Characteristics; Clinical; Computer Models; Data; Development; Diagnosis; Environment; Focused Ultrasound; Functional Imaging; Geometry; Goals; Hippocampus (Brain); Image; Interneurons; Lead; Measures; Mediating; Membrane; Methods; Modality; Modeling; Mus; Neurons; Neurosciences; Output; Physiologic pulse; Protocols documentation; Radiation; Research; Resolution; Role; Shapes; Somatostatin; Stimulus; Structure; Surface; Testing; Thalamic structure; Tissues; Transgenic Mice; Ultrasonic wave; Ultrasonics; Ultrasonography; Validation; Viscosity; awake; cell type; experimental study; flexibility; in vivo; insight; mathematical analysis; neglect; nervous system disorder; neuroregulation; novel; optogenetics; predictive modeling; pressure; relating to nervous system; response; scaffold; sensory input; simulation software; spatiotemporal; theories; tool; two photon microscopy; two-photon; vibration

Summary Neuroscience has an essential requirement for large-scale perturbation tools. Such tools would be transformative in the mapping of brain function, the causal testing of neurotheoretic models, and the diagnosis and treatment of neurological disorders. The proposed five-year project is aimed at uncovering the fundamental mechanisms of US stimulation through the reciprocity of mathematical analysis, computational modeling and experimental validation. Using a previously developed predicative model as a scaffold, we will build a full explanatory theory of US stimulation effects in mice, including cell-type specific effects of this perturbation modality. A large parameter space of US variables will be explored, including spatiotemporal dynamics and duty cycle modulation, while sensitive two-photon functional imaging metrics will be used to measure the biophysical impact of these parameters on neural responses in the cortex, thalamus, and hippocampus in vivo.

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