The biophysics and potential cell-type selectivity of acoustic neuromodulation

总结 神经科学对大规模扰动工具有基本要求。等 工具将是变革性的大脑功能的映射，因果测试， 神经理论模型，以及神经系统疾病的诊断和治疗。的 拟议的五年项目旨在揭示美国的基本机制， 通过数学分析、计算建模和 实验验证使用先前开发的预测模型作为支架，我们将 建立小鼠中US刺激效应的完整解释理论，包括细胞类型特异性 这种扰动模式的影响。将探索US变量的大参数空间， 包括时空动态和占空比调制，而敏感的双光子 功能成像度量将用于测量这些参数的生物物理影响 对大脑皮层、丘脑和海马体神经反应的影响。

Summary Neuroscience has an essential requirement for large-scale perturbation tools. Such tools would be transformative in the mapping of brain function, the causal testing of neurotheoretic models, and the diagnosis and treatment of neurological disorders. The proposed five-year project is aimed at uncovering the fundamental mechanisms of US stimulation through the reciprocity of mathematical analysis, computational modeling and experimental validation. Using a previously developed predicative model as a scaffold, we will build a full explanatory theory of US stimulation effects in mice, including cell-type specific effects of this perturbation modality. A large parameter space of US variables will be explored, including spatiotemporal dynamics and duty cycle modulation, while sensitive two-photon functional imaging metrics will be used to measure the biophysical impact of these parameters on neural responses in the cortex, thalamus, and hippocampus in vivo.