The biophysics and potential cell-type selectivity of acoustic neuromodulation

摘要 神经科学对大规模扰动工具有一个基本要求。这样的工具 将在脑功能图谱和诊断和治疗方面产生革命性的变化 神经紊乱。拟议的项目旨在揭示潜在的治疗作用。 关于阿尔茨海默病的美国神经调节(USNM)，对早期现象学的随访 关注美国的观察可能会产生这样的影响。 我们项目的目标是使用最先进的活体成像技术来了解 US可以用来研究和操纵脑脊液(CSF)在大脑中的流动， 联合使用US和同步荧光技术在阿尔茨海默病方面的应用 淀粉样蛋白-β和tau的显微镜观察。我们将研究大脑中的USNM效应是否会导致变化 在血液和脑脊液流动中，以及超声束诱导的血流是否影响淀粉样蛋白β或tau清除 大脑。

Summary Neuroscience has an essential requirement for large-scale perturbation tools. Such tools would be transformative in the mapping of brain function and the diagnosis and treatment of neurological disorders. The proposed project is aimed at uncovering a potential therapeutic role for US neuromodulation (USNM) in Alzheimer’s disease, following up on early phenomenological observations that focused US may have such an impact. Our project’s goal is to use state-of-the-art in vivo imaging techniques to understand how US could be used to study and manipulate cerebrospinal fluid (CSF) flow in the brain, with applications focused on Alzheimer’s disease, using combined US and simultaneous fluorescence microscopy of amyloid-β and tau. We will study if USNM effects in the brain can lead to changes in blood and CSF flow, and whether USNM induced flow effect amyloid-β or tau clearance in the brain.