The biophysics and potential cell-type selectivity of acoustic neuromodulation

总结 神经科学对大规模扰动工具有基本要求。此类工具 在绘制大脑功能图以及诊断和治疗 神经系统疾病拟议的项目旨在揭示潜在的治疗作用 用于阿尔茨海默病的US神经调节（USNM），随访早期现象学 美国的观察可能会产生这样的影响。 我们项目的目标是使用最先进的体内成像技术来了解 US可用于研究和操纵脑中的脑脊液（CSF）流动， 应用集中在阿尔茨海默氏病，使用组合的US和同步荧光 淀粉样蛋白-β和tau的显微镜检查。我们将研究USNM在大脑中的作用是否会导致改变， 在血液和CSF流动中，以及USNM诱导的流动是否影响淀粉样蛋白-β或tau的清除， 个脑袋

Summary Neuroscience has an essential requirement for large-scale perturbation tools. Such tools would be transformative in the mapping of brain function and the diagnosis and treatment of neurological disorders. The proposed project is aimed at uncovering a potential therapeutic role for US neuromodulation (USNM) in Alzheimer’s disease, following up on early phenomenological observations that focused US may have such an impact. Our project’s goal is to use state-of-the-art in vivo imaging techniques to understand how US could be used to study and manipulate cerebrospinal fluid (CSF) flow in the brain, with applications focused on Alzheimer’s disease, using combined US and simultaneous fluorescence microscopy of amyloid-β and tau. We will study if USNM effects in the brain can lead to changes in blood and CSF flow, and whether USNM induced flow effect amyloid-β or tau clearance in the brain.