The biophysics and potential cell-type selectivity of acoustic neuromodulation

声神经调节的生物物理学和潜在的细胞类型选择性

• 批准号: 10509833
• 负责人: Robert Crooks Froemke
• 金额: $ 35.24万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10509833
• 关键词: Acoustics; Alzheimer' s Disease; Amyloid beta-Protein; Biophysics; Blood; Blood Vessels; Brain; Brain Mapping; Cerebrospinal Fluid; Coupled; Diagnosis; Fluorescence Microscopy; Focused Ultrasound; Goals; Imaging Techniques; Lead; Neurosciences; Role; Structure; Therapeutic; Tissues; Ultrasonic wave; cell type; cerebrospinal fluid flow; in vivo imaging; nervous system disorder; neuroregulation; tau Proteins; tool; ultrasound

Summary Neuroscience has an essential requirement for large-scale perturbation tools. Such tools would be transformative in the mapping of brain function and the diagnosis and treatment of neurological disorders. The proposed project is aimed at uncovering a potential therapeutic role for US neuromodulation (USNM) in Alzheimer’s disease, following up on early phenomenological observations that focused US may have such an impact. Our project’s goal is to use state-of-the-art in vivo imaging techniques to understand how US could be used to study and manipulate cerebrospinal fluid (CSF) flow in the brain, with applications focused on Alzheimer’s disease, using combined US and simultaneous fluorescence microscopy of amyloid-β and tau. We will study if USNM effects in the brain can lead to changes in blood and CSF flow, and whether USNM induced flow effect amyloid-β or tau clearance in the brain.

总结 神经科学对大规模扰动工具有本质要求。此类工具 在绘制大脑功能图以及诊断和治疗 神经系统疾病拟议的项目旨在揭示潜在的治疗作用 用于阿尔茨海默病的US神经调节（USNM），随访早期现象学 美国的观察可能会产生这样的影响。 我们项目的目标是使用最先进的体内成像技术来了解 US可用于研究和操纵脑中的脑脊液（CSF）流动， 应用集中在阿尔茨海默氏病，使用组合的US和同步荧光 淀粉样蛋白-β和tau的显微镜检查。我们将研究USNM在大脑中的作用是否会导致改变， 在血液和CSF流动中，以及USNM诱导的流动是否影响淀粉样蛋白-β或tau的清除， 个脑袋

项目成果

High-resolution fluorescence-guided transcranial ultrasound mapping in the live mouse brain.

• DOI: 10.1126/sciadv.abi5464
• 发表时间: 2021-12-10
• 期刊: Science advances
• 影响因子: 13.6
• 作者: Estrada H;Robin J;Özbek A;Chen Z;Marowsky A;Zhou Q;Beck D;le Roy B;Arand M;Shoham S;Razansky D
• 通讯作者: Razansky D