The biophysics and potential cell-type selectivity of acoustic neuromodulation

声神经调节的生物物理学和潜在的细胞类型选择性

基本信息

项目摘要

Summary Neuroscience has an essential requirement for large-scale perturbation tools. Such tools would be transformative in the mapping of brain function and the diagnosis and treatment of neurological disorders. The proposed project is aimed at uncovering a potential therapeutic role for US neuromodulation (USNM) in Alzheimer’s disease, following up on early phenomenological observations that focused US may have such an impact. Our project’s goal is to use state-of-the-art in vivo imaging techniques to understand how US could be used to study and manipulate cerebrospinal fluid (CSF) flow in the brain, with applications focused on Alzheimer’s disease, using combined US and simultaneous fluorescence microscopy of amyloid-β and tau. We will study if USNM effects in the brain can lead to changes in blood and CSF flow, and whether USNM induced flow effect amyloid-β or tau clearance in the brain.
总结

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
High-resolution fluorescence-guided transcranial ultrasound mapping in the live mouse brain.
  • DOI:
    10.1126/sciadv.abi5464
  • 发表时间:
    2021-12-10
  • 期刊:
  • 影响因子:
    13.6
  • 作者:
    Estrada H;Robin J;Özbek A;Chen Z;Marowsky A;Zhou Q;Beck D;le Roy B;Arand M;Shoham S;Razansky D
  • 通讯作者:
    Razansky D
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Robert Crooks Froemke其他文献

Robert Crooks Froemke的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Robert Crooks Froemke', 18)}}的其他基金

Oxytocin modulation of a distributed neural circuit for maternal behavior
催产素调节分布式神经回路对母性行为的影响
  • 批准号:
    10438592
  • 财政年份:
    2018
  • 资助金额:
    $ 35.24万
  • 项目类别:
The biophysics and potential cell-type selectivity of acoustic neuromodulation
声神经调节的生物物理学和潜在的细胞类型选择性
  • 批准号:
    10218280
  • 财政年份:
    2018
  • 资助金额:
    $ 35.24万
  • 项目类别:
The biophysics and potential cell-type selectivity of acoustic neuromodulation
声神经调节的生物物理学和潜在的细胞类型选择性
  • 批准号:
    10469915
  • 财政年份:
    2018
  • 资助金额:
    $ 35.24万
  • 项目类别:
The biophysics and potential cell-type selectivity of acoustic neuromodulation
声神经调节的生物物理学和潜在的细胞类型选择性
  • 批准号:
    10455508
  • 财政年份:
    2018
  • 资助金额:
    $ 35.24万
  • 项目类别:
Oxytocin modulation of a distributed neural circuit for maternal behavior
催产素调节分布式神经回路对母性行为的影响
  • 批准号:
    10220156
  • 财政年份:
    2018
  • 资助金额:
    $ 35.24万
  • 项目类别:
Functional organization and plasticity of the oxytocin system for single or communal parenting in mice
小鼠单亲或共同养育催产素系统的功能组织和可塑性
  • 批准号:
    10705987
  • 财政年份:
    2018
  • 资助金额:
    $ 35.24万
  • 项目类别:
The biophysics and potential cell-type selectivity of acoustic neuromodulation
声神经调节的生物物理学和潜在的细胞类型选择性
  • 批准号:
    9788117
  • 财政年份:
    2018
  • 资助金额:
    $ 35.24万
  • 项目类别:
Neural circuitry of oxytocin signaling for alloparenting behavior
同种异体行为的催产素信号传导的神经回路
  • 批准号:
    10462895
  • 财政年份:
    2017
  • 资助金额:
    $ 35.24万
  • 项目类别:
Neural circuitry of oxytocin signaling for alloparenting behavior
同种异体行为的催产素信号传导的神经回路
  • 批准号:
    10580841
  • 财政年份:
    2017
  • 资助金额:
    $ 35.24万
  • 项目类别:
Neural Circuitry and Plasticity for Maternal Behavior
母亲行为的神经回路和可塑性
  • 批准号:
    9308448
  • 财政年份:
    2017
  • 资助金额:
    $ 35.24万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了