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phase 1 adaptive dose-escalation study of mycophenolate mofetil (MMF) in combination with temozolomide (TMZ) for patients with newly diagnosed glioblastoma

霉酚酸酯（MMF）联合替莫唑胺（TMZ）治疗新诊断胶质母细胞瘤患者的 1 期适应性剂量递增研究

基本信息

批准号：
10468354
负责人：
Atique U. Ahmed
金额：
$ 43.94万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-17 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10468354
关键词：
phase adaptive dose escalation study

项目摘要

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

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Atique U. Ahmed其他文献

Glioblastoma recurrence and the role of MGMT promoter methylation

胶质母细胞瘤复发和 MGMT 启动子甲基化的作用

DOI：
10.1101/317636
发表时间：
2018
期刊：
bioRxiv
影响因子：
0
作者：
K. Storey;K. Leder;A. Hawkins;K. Swanson;Atique U. Ahmed;R. Rockne;J. Foo
通讯作者：
J. Foo

Beyond the brain: exploring the impact of animal models of leptomeningeal disease from solid tumors

DOI：
10.1186/s40478-025-01959-4
发表时间：
2025-05-19
期刊：
Acta Neuropathologica Communications
影响因子：
5.700
作者：
Jillyn R. Turunen;Priya Kumthekar;Atique U. Ahmed
通讯作者：
Atique U. Ahmed

EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY

实验治疗学和药理学

DOI：
发表时间：
2013
期刊：
影响因子：
0
作者：
C. Aaberg;Louise Fogh;Bo Halle;V. Jensen;N. Brünner;B. Kristensen;T. Abe;Y. Momii;J. Watanabe;I. Morisaki;A. Natsume;T. Wakabayashi;M. Fujiki;Beatriz Aldaz;A. Fabius;J. Silber;Girish Harinath;T. Chan;J. Huse;S. Anai;T. Hide;Hideo Nakamura;K. Makino;S. Yano;J. Kuratsu;I. Balyasnikova;M. Prasol;Deepak K. Kanoija;K. Aboody;M. Lesniak;T. Barone;C. Burkhart;A. Purmal;A. Gudkov;K. Gurova;R. Plunkett;K. Barton;Katherine L. Misuraca;Francisco J. Cordero;E. Dobrikova;H. Min;M. Gromeier;D. Kirsch;O. Becher;L. B. Pont;J. Kloezeman;M. Bent;R. Kanaar;A. Kremer;S. Swagemakers;P. French;C. Dirven;M. Lamfers;S. Leenstra;R. Balvers;A. Kleijn;S. Lawler;X. Gong;A. Andres;Joseph A. Hanson;J. Delashaw;D. Bota;Chiao;N. Yao;W. Chuang;Chen Chang;Pin;Chiung;Kuo;Yuhu Cheng;Qing;R. Morshed;Yu Han;B. Auffinger;D. Wainwright;Lingjiao Zhang;Alex L. Tobias;E. Rincon;B. Thaci;Atique U. Ahmed;Chuang He;Young A. Choi;Hetal Pandya;D. Gibo;Isabela Fokt;W. Priebe;W. Debinski;Yevgen Chornenkyy;S. Agnihotri;P. Buczkowicz;P. Rakopoulos;A. Morrison;M. Barszczyk;C. Hawkins;Sylvia A. Chung;S. Decollogne;Peter P. Luk;Han Shen;Wendy Ha;B. Day;B. Stringer;P. Hogg;P. Dilda;K. McDonald;S. Moore;M. Hayden;J. Bergen;YouRong S. Su;H. Rayburn;M. Edwards;M. Scott;J. Cochran;Arabinda Das;A. Varma;G. Wallace;Yaenette N. Dixon;W. A. Vandergrift;P. Giglio;S. Ray;Sunil J. Patel;N. Banik;T. Dasgupta;A. Olow;Xiaodong Yang;S. Mueller;M. Prados;C. James;D. Haas;Nimita Dave;P. Desai;G. Gudelsky;L. Chow;K. LaSance;X. Qi;J. Driscoll;K. Ebsworth;M. Walters;L. Ertl;Yu Wang;Robert D. Berahovic;J. McMahon;J. Powers;J. Jaén;T. Schall;Z. Eroglu;J. Portnow;Arianne D. Sacramento;Elizabeth Garcia;A. Raubitschek;T. Synold;S. Esaki;S. Rabkin;R. Martuza;H. Wakimoto;S. Ferluga;C. M. L. Tomé;H. Førde;I. A. Netland;L. Sleire;B. Skeie;P. Enger;D. Goplen;M. Giladi;A. Tichon;R. Schneiderman;Y. Porat;M. Munster;Matan Dishon;U. Weinberg;E. Kirson;Yoram Wasserman;Y. Palti;D. Gramatzki;M. Staudinger;K. Frei;M. Peipp;M. Weller;C. Grasso;Lining Liu;Noah E. Berlow;L. Davis;M. Fouladi;A. Gajjar;Elaine C. Huang;E. Hulleman;M. Hutt;C. Keller;Xiao;P. Meltzer;Martha Quezado;M. Quist;Eric H. Raabe;P. Spellman;Nathalène Truffaux;Dannis van Vurden;Nicholas J. Wang;K. Warren;R. Pal;J. Grill;Michelle Monje;A. Green;S. Ramkissoon;D. McCauley;K. Jones;J. Perry;L. Ramkissoon;C. Maire;S. Shacham;K. Ligon;A. Kung;Katarzyna Zielinska;V. Grozman;J. Tu;K. Viktorsson;R. Lewensohn;Shiv K. Gupta;Ann C Mladek;K. Bakken;B. Carlson;F. Boakye;S. Kizilbash;M. Schroeder;J. Reid;J. Sarkaria;P. Hadaczek;T. Ozawa;L. Soroceanu;Y. Yoshida;Lisa Matlaf;Eric Singer;Estefania Fiallos;C. Cobbs;R. Hashizume;M. Tom;Yuichiro Ihara;R. Santos;J. D. L. Torre;Edgar L. Lepe;T. Waldman;D. James;Xi Huang;Lu Yu;N. Gupta;D. Solomon;Zhiguo Zhang;Takuro Hayashi;K. Adachi;S. Nagahisa;M. Hasegawa;Y. Hirose;M. Gephart;YouRong S. Su;Shawn D. Hingtgen;Randa Kasmieh;Irina Nesterenko;Jose;R. Dash;D. Sarkar;P. Fisher;K. Shah;Eric A. Horne;P. Diaz;N. Stella;Hongwei Yang;Tiffany T. Huang;J. Hlavaty;Derek Ostertag;Fernando Lopez Espinoza;B. Martin;H. Petznek;Maria E. Rodriguez;C. Ibañez;N. Kasahara;W. Günzburg;H. Gruber;D. Pertschuk;D. Jolly;J. Robbins;B. Hurwitz;J. Yoo;Chelsea M Bolyard;Jun‐ge Yu;Jeffery Wojton;Jianying Zhang;Zachary Bailey;D. Eaves;T. Cripe;M. Old;B. Kaur;L. Serwer;N. L. Moan;Sarah W S Ng;N. Butowski;A. Krtolica;S. Cary;T. Johns;S. Greenall;J. Donoghue;T. Adams;G. Karpel;M. Westhoff;R. Kast;A. Dwucet;C. Wirtz;K. Debatin;M. Halatsch;N. Merkur;Forrest M. Kievit;Zachary Stephen;Kui Wang;D. Kolstoe;J. Silber;R. Ellenbogen;Miqin Zhang;G. Kitange;Erik S. Haefner;Kristina H. Knubel;Ben M. Pernu;A. Sufit;Angela M Pierce;Sarah Nelson;A. Keating;S. S. Jensen;B. Kristensen;J. Lachowicz;M. Demeule;A. Régina;S. Tripathy;J. Curry;T. Nguyen;J. Castaigne;Tina N. Davis;A. Davis;Kevin Tanaka;T. Keating;Jennifer A. Getz;G. Kapp;J. M. Romero;Sang Y Lee;Srinivasa R. Ramisetti;Becky Slagle;Arun Sharma;J. Connor;Wen‐Shin Lee;M. Kluk;J. Aster;K. Ligon;Stella Sun;Derek Lee;A. Ho;J. Pu;Ziao Zhang;N. Lee;P. Day;G. Leung;Zhiguo Liu;Xiaoli Liu;A. Madhankumar;P. Miller;B. Webb;J. Connor;Qing X. Yang;Merryl R. Lobo;Sarah Green;M. Schabel;Y. Gillespie;R. Woltjer;M. Pike;Yu;J. D. L. Torre;H. A. Luchman;O. Stechishin;Stephanie A Nguyen;J. Cairncross;S. Weiss;X. Lun;J. Wells;X. Hao;Jun Zhang;Natalie Grinshtein;David L. Kaplan;Artee Luchman;D. Senger;S. Robbins;A. Madhankumar;Elias B Rizk;Russell Payne;Annie Park;Min Pang;K. Harbaugh;Anette Wilisch;D. Pachow;E. Kirches;C. Mawrin;S. Mcdonell;Ji Liang;Y. Piao;N. Nguyen;A. Yung;R. Verhaak;E. Sulman;C. Stephan;F. Lang;J. Groot;Yoshihumi Mizobuchi;Toshiyuki Okazaki;T. Kageji;Kazuyuki Kuwayama;K. Kitazato;H. Mure;Keijiro Hara;R. Morigaki;K. Matsuzaki;Kohei Nakajima;S. Nagahiro;S. Kumala;M. Heravi;S. Dević;T. Muanza;Kristina H. Knubel;A. Neuwelt;Tam Nguyen;Y. J. Wu;A. Donson;Rajeev Vibhakar;Sujatha Venkatamaran;V. Amani;E. Neuwelt;L. Rapkin;N. Foreman;Fady Ibrahim;P. New;K. Cui;Hong Zhao;D. Chow;W. Stephen;Kyoko Nozue;M. Nagane;K. McDonald;D. Ogawa;E. Chiocca;J. Godlewski;Akshal S. Patel;Nagarekha Pasupuleti;F. Gorin;Anthony Valenzuela;Leonardo J. Leon;K. Carraway;Chepapil Ramachandran;S. Nair;Karl;Z. Khatib;E. Escalon;S. Melnick;Andrew Phillips;E. Boghaert;Kedar S Vaidya;P. Ansell;D. Shalinsky;Yumin Zhang;Martin J. Voorbach;Sarah R. Mudd;K. Holen;R. Humerickhouse;E. Reilly;S. Parab;Oscar R. Diago;D. Jolly;T. Ryken;Supreet Agarwal;M. Al;M. Alqudah;Zita A. Sibenaller;Mahfoud Assemolt;K. Sai;Wen;Weiping Li;Zhongwu Chen;R. Saito;Y. Sonoda;Masayuki Kanamori;Y. Yamashita;T. Kumabe;T. Tominaga;G. Sarkar;G. Curran;R. Jenkins;R. Scharnweber;Yuki Kato;Jeff Lin;R. Everson;H. Soto;C. Kruse;L. Liau;R. Prins;Samantha L Semenkow;Q. Chu;C. Eberhart;Rajarshi Sengupta;J. Marassa;D. Piwnica;J. Rubin;R. Shai;Tatyana Pismenyuk;Itai Moshe;Tamar Fisher;Shani Freedman;A. Simon;N. Amariglio;G. Rechavi;A. Toren;M. Yalon;Y. Shimazu;K. Kurozumi;T. Ichikawa;K. Fujii;Manabu Onishi;Joji Ishida;T. Oka;Masami Watanabe;Y. Nasu;H. Kumon;I. Date;R. Sirianni;Rebecca L. McCall;J. Spoor;M. V. D. Kaaij;Mieke Geurtjens;Omid Veiseh;Chen Fang;M. Leung;G. Strohbehn;K. Atsina;T.R. Patel;J. Piepmeier;Jiangbing Zhou;W. Saltzman;Masamichi Takahashi;G. Valdes;Akihito Inagaki;Shuichi Kamijima;K. Hiraoka;E. Micewicz;W. McBride;K. Iwamoto;C. McCully;J. Bacher;T. Thomas;R. Murphy;E. Steffen;R. Mcallister;Devang Pastakia;B. Widemann;H. Yang;M. Hua;Hao;Eric C. Woolf;M. Abdelwahab;Kathryn E. Fenton;Qingwei Liu;G. Turner;M. Preul;A. Scheck;W. Shen;Dennis Brown;H. Pedersen;Jie Zhang;S. Hariono;Tsun‐Wen Yao;Angadpreet Sidhu;W. Weiss;T. Nicolaides;Temidayo O B Olusanya
通讯作者：
Temidayo O B Olusanya

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

DNA 损伤反应、翻译和凋亡体之间的相互作用决定了癌症对 TOP2 毒物的易感性

DOI：
10.1101/614024
发表时间：
2019
期刊：
bioRxiv
影响因子：
0
作者：
Chidiebere U. Awah;Li Chen;M. Bansal;A. Mahajan;Jan Winter;Meeki K. Lad;L. Warnke;E. González;Cheol Park;Zhang Daniel;Eric Feldstein;Dou Yu;Markella Zannikou;I. Balyasnikova;Regina T. Martuscello;Silvana Konerman;Balázs Győrffy;K. Burdett;D. Scholtens;R. Stupp;Atique U. Ahmed;P. Hsu;A. Sonabend
通讯作者：
A. Sonabend

Activation of dopamine receptor 2 (DRD2) prompts transcriptomic and metabolic plasticity in glioblastoma

多巴胺受体 2 (DRD2) 的激活促进胶质母细胞瘤的转录组和代谢可塑性

DOI：
10.1101/454389
发表时间：
2018
期刊：
bioRxiv
影响因子：
0
作者：
Seamus Caragher;Jack M. Shireman;Mei Huang;J. Miska;Cheol Shivani Baisiwala;Hong Park;Miranda R Saathoff;L. Warnke;Ting Xiao;M. Lesniak;David James;H. Meltzer;A. Tryba;Atique U. Ahmed
通讯作者：
Atique U. Ahmed