American Cohort to Study HIV Acquisition among Transgender Women in High Risk Areas
美国队列研究高风险地区跨性别女性的艾滋病毒感染情况
基本信息
- 批准号:10471073
- 负责人:
- 金额:$ 10.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-21 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAIDS/HIV problemAcquired Immunodeficiency SyndromeAddressAdherenceAffectAmericanAncillary StudyAreaBaltimoreBehavioralBiologicalBloodBostonCaringCohort StudiesCollectionContinuity of Patient CareCountryCross-Sectional StudiesDataDevelopmentEligibility DeterminationEnrollmentEnvironmentEpidemicEpidemiologyExposure toFundingFutureGeneral PopulationGuidelinesHIVHIV InfectionsHIV riskHealthHealth ServicesHigh PrevalenceHormone useIncidenceIndividualInfrastructureInterventionIntervention StudiesLaboratoriesLongitudinal cohortMeasuresMental HealthMeta-AnalysisMethodsNew York CityOutcomeParticipantPatient Self-ReportPhasePopulationPopulation InterventionPopulations at RiskPrevalencePreventionPrevention ResearchPrincipal InvestigatorProductivityProspective cohortResearchResearch PriorityRiskRisk FactorsSample SizeSamplingSampling BiasesSiteSpecimenStructureSubgroupTechnologyTestingTimeUnited StatesUnited States National Institutes of HealthValidationViral Load resultVisitWashingtonWomanbasebehavioral healthbiobehaviorcare systemscohortcomparison groupdesignevidence basefollow-uphigh riskimprovedmen who have sex with menmetropolitannew technologyphysical conditioningplacebo grouppre-exposure prophylaxispreventprevention servicepreventive interventionprospectiveracial and ethnicrecruitresponsescreeningself testingsocialsocial structuresocioeconomicssuccesstesting servicestransgender womentransmission processtrend
项目摘要
Abstract:
In the United States (U.S.), transgender women (TW) are one of the populations most affected by HIV
infection. The high prevalence of HIV infection among U.S. TW is driven by, and/or concomitant with, structural
barriers that limit access to HIV prevention, care, and health services. Despite an emergence of research to
characterize the HIV epidemic among TW, the majority of studies are cross-sectional designs and typically
include small sample sizes, often subsuming TW among broader risk groups, such as men who have sex with
men. These practices have thwarted identification of acceptable, effective recruitment and study methods for
use among TW and prevented temporal assessment, causal inference, and generalizability of study findings to
the TW population. To date, there is no robust estimate of HIV incidence and no intervention with evidence of
efficacy for the prevention of HIV acquisition among TW. The proposed American Cohort study will address
these limitations by establishing a multi-site, longitudinal cohort of TW spanning eastern and southern U.S.
(Boston, New York City, Baltimore-Washington, Atlanta, and Miami metropolitan areas) to characterize HIV
incidence and risk factors for HIV acquisition, access to biobehavioral HIV prevention methods, and linkage to
care for those who HIV seroconvert. The cohort will include a racially/ethnically and culturally diverse sample of
TW, supported by the use of technology-infused recruitment and retention methods. The specific aims are: 1)
To determine the efficiency and acceptability of novel, technology-infused recruitment methods to enroll HIV-
uninfected TW into a prospective cohort. 2) To describe the demographic, socioeconomic, behavioral, and
physical and mental health profiles of HIV-uninfected TW in the first, multi-site cohort of TW in the eastern and
southern U.S. 3) To estimate HIV incidence among TW in high-risk eastern and southern U.S. areas, trends in
incidence, and associated individual, social, and structural risk factors. 4) To estimate the HIV Prevention
Continuum among HIV-uninfected participants, and the HIV Care Continuum among newly HIV-infected TW.
To achieve these aims we will recruit 1,750 TW who will be enrolled in either a HIV-uninfected cohort or an
HIV-infected cross-sectional comparison group. These data will be used to assess differences between cohort
participants and the wider population and for cross-sectional incidence estimation at enrollment. The HIV-
uninfected cohort will be followed for at least 24 months to estimate HIV incidence, trends, and risk factors for
HIV acquisition. Cohort participants who seroconvert will be followed for an additional 6 months to assess
prospective engagement in the HIV Care Continuum. Study findings will provide critical epidemiologic
parameters for future HIV prevention research among TW, provide a platform upon which other research
questions can be explored, and inform the development of evidence-based and acceptable HIV interventions
to reduce HIV acquisition among TW in the U.S.
摘要:
在美国,变性人妇女(TW)是受艾滋病毒影响最大的人群之一
感染。美国TW中艾滋病毒感染的高流行率是由结构性因素推动和/或伴随的
限制获得艾滋病毒预防、护理和卫生服务的障碍。尽管出现了一项研究
描述TW中艾滋病毒流行的特征,大多数研究都是横断面设计,通常
包括较小样本量,通常将TW归入更广泛的风险群体,例如与之发生性关系的男性
男人。这些做法阻碍了确定可接受的、有效的招聘和研究方法
在TW和预防时间评估、因果推理和研究结果的概括性之间的使用
台湾州的人口。到目前为止,没有关于艾滋病毒发病率的可靠估计,也没有证据表明干预措施
台湾区妇女预防HIV感染的效果。拟议的美国队列研究将解决
这些限制是通过建立一个横跨美国东部和南部的多地点纵向TW队列来实现的。
(波士顿、纽约市、巴尔的摩-华盛顿、亚特兰大和迈阿密大都会地区)来表征艾滋病毒
艾滋病毒感染的发病率和风险因素,获得生物行为艾滋病毒预防方法的机会,以及与
照顾那些艾滋病毒血清转换的人。该队列将包括种族/民族和文化多样性的样本
TW,通过使用技术灌输的招聘和保留方法提供支持。具体目标是:1)
为了确定新的、注入技术的招募方法来招募艾滋病毒的效率和可接受性-
将未感染的TW纳入预期队列。2)描述人口统计、社会经济、行为和
东部和东部第一批未感染HIV的TW人群的身心健康状况
3)为了估计美国东部和南部高危地区TW地区的艾滋病毒发病率,
发病率,以及相关的个人、社会和结构性风险因素。4)评估艾滋病预防工作
在未感染艾滋病毒的参与者中继续开展艾滋病毒护理活动,在新感染艾滋病毒的台湾妇女中开展艾滋病毒护理活动。
为了实现这些目标,我们将招募1,750名TW,他们将被纳入未感染艾滋病毒的队列或
HIV感染横断面对照组。这些数据将被用来评估队列之间的差异
参与者和更广泛的人群,并在登记时进行横断面发病率估计。艾滋病病毒--
将对未感染的队列进行至少24个月的跟踪,以评估艾滋病毒的发病率、趋势和风险因素
艾滋病病毒的获取。血清转换的队列参与者将被再跟踪6个月以进行评估
预期参与艾滋病毒护理连续体。研究结果将提供关键的流行病学
为TW中未来的HIV预防研究提供参数,为其他研究提供平台
可以探索问题,并为发展以证据为基础和可接受的艾滋病毒干预措施提供信息
减少美国TW人群中艾滋病病毒的感染。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Sari Reisner', 18)}}的其他基金
Strategies to Prevent HIV Acquisition Among Transgender MSM in the US
美国跨性别男男性接触者预防艾滋病毒感染的策略
- 批准号:
10687266 - 财政年份:2022
- 资助金额:
$ 10.37万 - 项目类别:
Enhanced COhort methods for HIV Research and Epidemiology (ENCORE) among transgender women in the United States
美国跨性别女性的艾滋病毒研究和流行病学增强队列方法 (ENCORE)
- 批准号:
10537314 - 财政年份:2022
- 资助金额:
$ 10.37万 - 项目类别:
Enhanced COhort methods for HIV Research and Epidemiology (ENCORE) among transgender women in the United States
美国跨性别女性的艾滋病毒研究和流行病学增强队列方法 (ENCORE)
- 批准号:
10681497 - 财政年份:2022
- 资助金额:
$ 10.37万 - 项目类别:
Strategies to Prevent HIV Acquisition Among Transgender MSM in the US
美国跨性别男男性接触者预防艾滋病毒感染的策略
- 批准号:
10548087 - 财政年份:2022
- 资助金额:
$ 10.37万 - 项目类别:
TransHealthGUIDE: Transforming Health for Gender-Diverse Youth Using Interventions to Drive Equity
TransHealthGUIDE:利用干预措施推动公平,改变性别多元化青年的健康状况
- 批准号:
10413458 - 财政年份:2021
- 资助金额:
$ 10.37万 - 项目类别:
TransHealthGUIDE: Transforming Health for Gender-Diverse Youth Using Interventions to Drive Equity
TransHealthGUIDE:利用干预措施推动公平,改变性别多元化青年的健康状况
- 批准号:
10831881 - 财政年份:2021
- 资助金额:
$ 10.37万 - 项目类别:
American Cohort to Study HIV Acquisition among Transgender Women in High Risk Areas
美国队列研究高风险地区跨性别女性的艾滋病毒感染情况
- 批准号:
10405712 - 财政年份:2020
- 资助金额:
$ 10.37万 - 项目类别:
HIV Risk and Psychosocial Health Among Transgender Women in Peru
秘鲁跨性别女性的艾滋病毒风险和心理健康
- 批准号:
10215849 - 财政年份:2019
- 资助金额:
$ 10.37万 - 项目类别:
American Cohort to Study HIV Acquisition among Transgender Women in High Risk Areas
美国队列研究高风险地区跨性别女性的艾滋病毒感染情况
- 批准号:
9982768 - 财政年份:2017
- 资助金额:
$ 10.37万 - 项目类别:
American Cohort to Study HIV Acquisition among Transgender Women in High Risk Areas
美国队列研究高风险地区跨性别女性的艾滋病毒感染情况
- 批准号:
10224024 - 财政年份:2017
- 资助金额:
$ 10.37万 - 项目类别: