H3Africa Kidney Disease Research Network- Collaborative Centers

H3Africa 肾脏疾病研究网络 - 合作中心

基本信息

项目摘要

Chronic kidney disease (CKD) including end stage renal disease (CKD stage 5) is a major health problem in sub-Saharan Africa (SSA) affecting more than 50 million individuals but there is lamentable lack of research data and there is no promise of urgently needed preventative strategies. The lack of data on CKD in SSA are in part due to the absence of population-based epidemiologic studies of CKD and a scarcity of physician scientists conducting genetic, clinical and translational research on CKD according to local priorities. Herein, we propose to leverage the H3Africa Kidney Disease Research Network (H3A-KDRN) to (i) conduct genomics, clinical and translational research on the most prevalent forms of CKD; (ii) expand and support a well-trained cadre of African researchers and physician scientists to conduct CKD research according to regional priorities; (iii) engage SSA communities and research participants in the initiation, governance, implementation and dissemination of CKD research and (iv) foster collaboration with U.S.-based basic, clinical and translational researchers (including Africans in the diaspora) to elucidate etiologies and mechanisms and discover effective therapeutic and preventative strategies to combat the extraordinary burden of CKD in people of African ancestry globally The H3A-KDRN is organized as a research consortium initially composed of: (a) 15 academic medical centers/university teaching hospitals in five African countries- Cameroon - 1, Ghana – 4, Nigeria – 8, South Africa - 1 and Tanzania – 1; (b) 9 North American/Israeli research intensive academic medical institutions; (c) 3 shared cores – Training and Career Development, Data Management and Biostatistics and Genotyping Laboratories. At the end of the five-year funding requested in this application, The H3AKDRN will have accomplished the following: 1. Completion of three research projects on: (i) CKD in HIV-infected patients; and (ii) childhood and adolescent onset nephrotic syndrome and (iii) sickle cell disease nephropathy. These three prospective cohort studies will have a total sample size of 5800 participants. 2. Completion of training of four African-based research scientists toward PhD (n=2) and MSc (n=1) in Clinical and Translational Science (CTS) awarded by the University of Arizona 3. Completion of certificate training in clinical research methods for 45 African-based research personnel 4. Establish a high functioning regional Clinical and Translational Research Coordinating Center to support multicenter research in CKD and other non-communicable chronic diseases in SSA. With these foundational objectives, the H3Africa Kidney Disease Research Network will a transformative impact on CKD research in SSA and thence move us closer to the goal of reducing the burden of CKD in the 352 million Africans living in the five H3A-KDRN countries and in the 1.2 billion people of African descent globally.
慢性肾脏疾病(CKD)包括终末期肾脏疾病(CKD第5期)是我国主要的健康问题

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement.
  • DOI:
    10.1016/j.kint.2020.07.045
  • 发表时间:
    2021-01
  • 期刊:
  • 影响因子:
    19.6
  • 作者:
    Esezobor, Christopher;Ademola, Adebowale D.;Adetunji, Adewale E.;Anigilaje, Emmanuel A.;Batte, Anthony;Jiya-Bello, Fatima N.;Furia, Francis F.;Muoneke, Uzoamaka;McCulloch, Mignon;Nourse, Peter;Obiagwu, Patience;Odetunde, Odutola;Okyere, Perditer;Solarin, Adaobi;Tannor, Elliot K.;Noone, Damien;Gbadegesin, Rasheed;Parekh, Rulan S.
  • 通讯作者:
    Parekh, Rulan S.
Association Between Perfluoroalkyl Substance Exposure and Renal Function in Children With CKD Enrolled in H3Africa Kidney Disease Research Network.
全氟烷基物质暴露与加入 H3Africa 肾脏疾病研究网络的 CKD 儿童肾功能之间的关联。
  • DOI:
    10.1016/j.ekir.2019.07.017
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    6
  • 作者:
    Sood,Shefali;Ojo,AkinloluO;Adu,Dwomoa;Kannan,Kurunthachalam;Ghassabian,Akhgar;Koshy,Tony;Vento,SuzanneM;Pehrson,LauraJane;Gilbert,JosephF;Arogundade,FatiuA;Ademola,AdebowaleD;Salako,BabatundeO;Raji,Yami;Osafo,Charlotte;A
  • 通讯作者:
    A
HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria.
  • DOI:
    10.3389/fmed.2021.718300
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    Kruzel-Davila E;Sankofi BM;Kubi Amos-Abanyie E;Ghansah A;Nyarko A;Agyemang S;Awandare GA;Szwarcwort-Cohen M;Reiner-Benaim A;Hijazi B;Ulasi I;Raji YR;Boima V;Osafo C;May Adabayeri V;Matekole M;Olanrewaju TO;Ajayi S;Mamven M;Antwi S;Ademola AD;Plange-Rhule J;Arogundade F;Akyaw PA;Winkler CA;Salako BL;Ojo A;Skorecki K;Adu D
  • 通讯作者:
    Adu D
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Dwomoa Adu其他文献

Dwomoa Adu的其他文献

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{{ truncateString('Dwomoa Adu', 18)}}的其他基金

The H3Africa Kidney Disease Cohort Study
H3Africa 肾脏疾病队列研究
  • 批准号:
    10001248
  • 财政年份:
    2019
  • 资助金额:
    $ 22.99万
  • 项目类别:
H3Africa Kidney Disease Research Network
H3非洲肾脏疾病研究网络
  • 批准号:
    9430684
  • 财政年份:
    2017
  • 资助金额:
    $ 22.99万
  • 项目类别:
The H3Africa Kidney Disease Cohort Study
H3Africa 肾脏疾病队列研究
  • 批准号:
    8986048
  • 财政年份:
    2015
  • 资助金额:
    $ 22.99万
  • 项目类别:
The H3Africa Kidney Disease Cohort Study
H3Africa 肾脏疾病队列研究
  • 批准号:
    9148192
  • 财政年份:
    2015
  • 资助金额:
    $ 22.99万
  • 项目类别:
H3Africa Kidney Disease Research Network- Collaborative Centers
H3Africa 肾脏疾病研究网络 - 合作中心
  • 批准号:
    9792262
  • 财政年份:
    2012
  • 资助金额:
    $ 22.99万
  • 项目类别:
H3Africa Kidney Disease Research Network- Collaborative Centers
H3Africa 肾脏疾病研究网络 - 合作中心
  • 批准号:
    9789517
  • 财政年份:
    2012
  • 资助金额:
    $ 22.99万
  • 项目类别:
H3Africa Kidney Disease Research Network- Collaborative Centers
H3Africa 肾脏疾病研究网络 - 合作中心
  • 批准号:
    10262924
  • 财政年份:
    2012
  • 资助金额:
    $ 22.99万
  • 项目类别:
H3Africa Kidney Disease Research Network
H3非洲肾脏疾病研究网络
  • 批准号:
    8737361
  • 财政年份:
    2012
  • 资助金额:
    $ 22.99万
  • 项目类别:
H3Africa Kidney Disease Research Network
H3非洲肾脏疾病研究网络
  • 批准号:
    8392419
  • 财政年份:
    2012
  • 资助金额:
    $ 22.99万
  • 项目类别:
H3Africa Kidney Disease Research Network
H3非洲肾脏疾病研究网络
  • 批准号:
    8530165
  • 财政年份:
    2012
  • 资助金额:
    $ 22.99万
  • 项目类别:

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  • 批准号:
    9212055
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