H3Africa Kidney Disease Research Network- Collaborative Centers
H3Africa 肾脏疾病研究网络 - 合作中心
基本信息
- 批准号:10468418
- 负责人:
- 金额:$ 22.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-08-15 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS-Associated NephropathyAcademic Medical CentersAdolescentAdvocacyAffectAfricaAfrica South of the SaharaAfricanAllelesAmericanApolipoproteinsArizonaAwardBiomedical ResearchBiometryBirthCameroonCaringCertificationChildChildhoodChronic DiseaseChronic Kidney FailureClinicalClinical ResearchClinical SciencesClinical and Translational Science AwardsCollaborationsCompetenceCountryDataDeveloped CountriesDevelopmentDiseaseDissemination and ImplementationDoctor of PhilosophyEducational workshopEnd stage renal failureEnsureEtiologyEventExtramural ActivitiesFosteringFoundationsFunctional disorderFundingGenesGeneticGenetic ResearchGenomicsGenotypeGhanaGoalsGovernment AgenciesGrantHIVHealthHealth FairsHealth SciencesHistopathologyHuman GeneticsHuman ResourcesIndividualInstitutionKidneyKidney DiseasesLaboratoriesLaboratory StudyLife Cycle StagesLife ExpectancyMedicalMedical GeneticsModalityModernizationNephrotic SyndromeNigeriaNursing ResearchOutcomeParticipantPatientsPhysiciansPopulationPrevalencePrevention strategyProspective cohort studyProteinuriaProtocols documentationPublic HealthResearchResearch MethodologyResearch PersonnelResearch Project GrantsRiskRisk FactorsSample SizeScientistSeveritiesSickle Cell AnemiaSouth AfricaSteroid-resistant idiopathic nephrotic syndromeStrokeTanzaniaTeaching HospitalsTechnologyTenofovirTrainingTranslational ResearchTubular formationUnited States National Institutes of HealthUniversitiesVariantVirus DiseasesWorkacute chest syndromeantiretroviral therapybasecareer developmentcombatcommunity based participatory researchcommunity engagementcomorbiditydata managementepidemiology studyethical legal social implicationgenetic informationhigh riskimprovedmedical schoolsnephrotoxicitypediatric patientspopulation basedprecision medicinepreventrisk variantstudy populationsupport networktherapeutically effectivetranslational scientisttreatment strategyworking groupyoung adult
项目摘要
Chronic kidney disease (CKD) including end stage renal disease (CKD stage 5) is a major health problem in
sub-Saharan Africa (SSA) affecting more than 50 million individuals but there is lamentable lack of research data
and there is no promise of urgently needed preventative strategies. The lack of data on CKD in SSA are in part
due to the absence of population-based epidemiologic studies of CKD and a scarcity of physician scientists
conducting genetic, clinical and translational research on CKD according to local priorities. Herein, we propose
to leverage the H3Africa Kidney Disease Research Network (H3A-KDRN) to (i) conduct genomics, clinical and
translational research on the most prevalent forms of CKD; (ii) expand and support a well-trained cadre of African
researchers and physician scientists to conduct CKD research according to regional priorities; (iii) engage SSA
communities and research participants in the initiation, governance, implementation and dissemination of CKD
research and (iv) foster collaboration with U.S.-based basic, clinical and translational researchers (including
Africans in the diaspora) to elucidate etiologies and mechanisms and discover effective therapeutic and
preventative strategies to combat the extraordinary burden of CKD in people of African ancestry globally The
H3A-KDRN is organized as a research consortium initially composed of: (a) 15 academic medical
centers/university teaching hospitals in five African countries- Cameroon - 1, Ghana – 4, Nigeria – 8, South Africa
- 1 and Tanzania – 1; (b) 9 North American/Israeli research intensive academic medical institutions; (c) 3 shared
cores – Training and Career Development, Data Management and Biostatistics and Genotyping Laboratories.
At the end of the five-year funding requested in this application, The H3AKDRN will have accomplished the
following:
1. Completion of three research projects on: (i) CKD in HIV-infected patients; and (ii) childhood and adolescent
onset nephrotic syndrome and (iii) sickle cell disease nephropathy. These three prospective cohort studies
will have a total sample size of 5800 participants.
2. Completion of training of four African-based research scientists toward PhD (n=2) and MSc (n=1) in Clinical
and Translational Science (CTS) awarded by the University of Arizona
3. Completion of certificate training in clinical research methods for 45 African-based research personnel
4. Establish a high functioning regional Clinical and Translational Research Coordinating Center to support
multicenter research in CKD and other non-communicable chronic diseases in SSA.
With these foundational objectives, the H3Africa Kidney Disease Research Network will a transformative impact
on CKD research in SSA and thence move us closer to the goal of reducing the burden of CKD in the 352 million
Africans living in the five H3A-KDRN countries and in the 1.2 billion people of African descent globally.
慢性肾脏疾病(CKD)包括终末期肾脏疾病(CKD第5期)是我国主要的健康问题
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement.
- DOI:10.1016/j.kint.2020.07.045
- 发表时间:2021-01
- 期刊:
- 影响因子:19.6
- 作者:Esezobor, Christopher;Ademola, Adebowale D.;Adetunji, Adewale E.;Anigilaje, Emmanuel A.;Batte, Anthony;Jiya-Bello, Fatima N.;Furia, Francis F.;Muoneke, Uzoamaka;McCulloch, Mignon;Nourse, Peter;Obiagwu, Patience;Odetunde, Odutola;Okyere, Perditer;Solarin, Adaobi;Tannor, Elliot K.;Noone, Damien;Gbadegesin, Rasheed;Parekh, Rulan S.
- 通讯作者:Parekh, Rulan S.
APOL1 genotype associated risk for preeclampsia in African populations: Rationale and protocol design for studies in women of African ancestry in resource limited settings.
- DOI:10.1371/journal.pone.0278115
- 发表时间:2022
- 期刊:
- 影响因子:3.7
- 作者:
- 通讯作者:
Association Between Perfluoroalkyl Substance Exposure and Renal Function in Children With CKD Enrolled in H3Africa Kidney Disease Research Network.
全氟烷基物质暴露与加入 H3Africa 肾脏疾病研究网络的 CKD 儿童肾功能之间的关联。
- DOI:10.1016/j.ekir.2019.07.017
- 发表时间:2019
- 期刊:
- 影响因子:6
- 作者:Sood,Shefali;Ojo,AkinloluO;Adu,Dwomoa;Kannan,Kurunthachalam;Ghassabian,Akhgar;Koshy,Tony;Vento,SuzanneM;Pehrson,LauraJane;Gilbert,JosephF;Arogundade,FatiuA;Ademola,AdebowaleD;Salako,BabatundeO;Raji,Yami;Osafo,Charlotte;A
- 通讯作者:A
HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria.
- DOI:10.3389/fmed.2021.718300
- 发表时间:2021
- 期刊:
- 影响因子:3.9
- 作者:Kruzel-Davila E;Sankofi BM;Kubi Amos-Abanyie E;Ghansah A;Nyarko A;Agyemang S;Awandare GA;Szwarcwort-Cohen M;Reiner-Benaim A;Hijazi B;Ulasi I;Raji YR;Boima V;Osafo C;May Adabayeri V;Matekole M;Olanrewaju TO;Ajayi S;Mamven M;Antwi S;Ademola AD;Plange-Rhule J;Arogundade F;Akyaw PA;Winkler CA;Salako BL;Ojo A;Skorecki K;Adu D
- 通讯作者:Adu D
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Dwomoa Adu其他文献
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{{ truncateString('Dwomoa Adu', 18)}}的其他基金
H3Africa Kidney Disease Research Network- Collaborative Centers
H3Africa 肾脏疾病研究网络 - 合作中心
- 批准号:
9792262 - 财政年份:2012
- 资助金额:
$ 22.99万 - 项目类别:
H3Africa Kidney Disease Research Network- Collaborative Centers
H3Africa 肾脏疾病研究网络 - 合作中心
- 批准号:
9789517 - 财政年份:2012
- 资助金额:
$ 22.99万 - 项目类别:
H3Africa Kidney Disease Research Network- Collaborative Centers
H3Africa 肾脏疾病研究网络 - 合作中心
- 批准号:
10262924 - 财政年份:2012
- 资助金额:
$ 22.99万 - 项目类别:
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