2022 & 2024 Drug Resistance Gordon Research Conference and Seminar

项目总结 现代世界的繁荣正受到不断出现的抗药性的威胁 病原体、抗农药昆虫和抗除草剂杂草。新的调查 抗癌药物可以延长预期寿命，但当耐药性产生时，不可避免地会失败。虽然 耐药性的威胁是共同的，传染病、癌症和农业领域 基本上是独立回应的。对耐药性的研究通常是在特定的生物体中进行的 会议--甚至在传染病领域，致力于抗菌药、抗真菌药、 抗寄生虫药和抗病毒药很少交流。2022年戈登研究会议 抗药性独特地将研究传染病、抗癌的科学家聚集在一起 药物、杀虫剂和除草剂讨论抗药性的共同威胁。我们是 请求为这些会议提供部分支持，以支付以下会议的注册费和差旅费 演讲者和选定的与会者，特别是早期职业调查人员、博士后和研究生 学生们。我们的目标是推出一个有36名演讲者的项目，从海报摘要中挑选8-12名演讲者， 有9个会议描述了该领域的最新进展。开幕/闭幕主旨会议 将是(1)理解抗性机制的挑战和机遇 农业和(9)新出现的抗药性战略。其他课程将包括(2) 抗性机制，(3)解决抗性的系统和建模策略，(4) (5)耐用药物设计；(6)生态进化 应对抗性的战略，(7)威胁和应对，以及(8)微生物组和 抵抗。演讲者和讨论负责人将从以下领域招募 传染病、癌症和农业，来自学者、政府组织、 基金会和产业(大大小小的)。我们还将积极招募一批 来自许多不同国家和机构的与会者，具有不同的专业知识，新的 观点和开放的思维，因为这次会议的成功依赖于国外 学科代表性，不同的资历，以及广泛的地理和文化视角。 所有与会者将可以选择在下午的海报会议上展示他们的作品，以及 初级调查人员还将有机会参加与戈登研究有关的 研讨会。会议还将包括GRC Power Hour，以讨论和解决 女性在这一领域面临的挑战。

PROJECT SUMMARY The prosperity of the modern world is threatened by the relentless emergence of drug-resistant pathogens, pesticide-resistant insects and herbicide-resistant weeds. New investigational cancer drugs increase life expectancy, but inevitably fail when resistance develops. Although the threat of resistance is shared, the fields of infectious disease, cancer and agriculture have largely responded independently. Work on resistance is typically siloed in organism-specific conferences- even within infectious diseases, scientists working on antibacterials, antifungals, antiparasitics, and antivirals rarely communicate. The 2022 Gordon Research Conference on Drug Resistance uniquely bring together scientists studying infectious disease, anticancer agents, insecticides and herbicides to discuss the common threat of resistance. We are requesting partial support for these conferences to defray registration and travel expenses for speakers and select attendees, specifically early career investigators, post docs and graduate students. Our goal is to mount a program of 36 speakers, 8-12 chosen from poster abstracts, with 9 sessions describing recent advances in the field. The opening/closing keynote sessions will be (1) Challenges and Opportunities of Understanding Resistance Mechanisms in Agriculture and (9) Emerging Strategies to Combat Resistance. Other sessions will include (2) Mechanisms of Resistance, (3) Systems and Modeling Strategies to Address Resistance, (4) Combating Resistance with Novel Targets, (5) Durable Drug Design, (6) Eco-Evolutionary Strategies to Address Resistance, (7) Threats and Responses and (8) The Microbiome and Resistance. The speakers and discussion leaders will be recruited from across the fields of infectious disease, cancer and agriculture, drawn from academics, government organizations, foundations and industry (both small and large). We will also aggressively recruit a mix of attendees from many different countries and institutions, with diverse expertise, new perspectives and open minds because the success of this conference relies on abroad representation of disciplines, varying seniority, and wide geographic and cultural perspectives. All attendees will have the option of presenting their work during afternoon poster sessions and junior investigators will also have the opportunity to attend an associated Gordon Research Seminar. The meeting will also include a GRC Power hour to discuss and address the challenges women face in the field.