Enzymes, Coenzyme Metabolic Pathways Gordon Research Conference

描述(由申请人提供)：通过这项建议，我们寻求对2008年和2009年戈登研究会议的部分支持，该会议的主题是“酶、辅酶和代谢途径”，定于2008年7月13-18日和2009年7月12-17日在缅因州比德福德的新英格兰大学举行。这次会议的广泛和长期目标是促进对生物过程的分子水平的理解，包括生化途径及其相关催化剂。我们的具体目标是介绍一个由36名演讲者组成的节目，8名演讲者选自海报摘要，描述天然产物生物合成的最新进展、代谢途径的新方法、蛋白质运动、药物酶学进展、核酸酶学、信号转导、调节蛋白分解和酶学前沿。下午的海报会议为所有与会者提供了一个展示他们工作的场所，为初级调查人员提供了与外地高级调查人员互动的机会。这一建议的意义在于，GRC酶是研究生化反应分子机制的研究人员的试金石。这一应用的健康相关性源于这样一个事实，即疾病过程的分子描述对于化疗的设计是不可或缺的。

DESCRIPTION (provided by applicant): With this proposal, we seek partial support for the 2008 and 2009 Gordon Research Conferences on "Enzymes, Coenzymes and Metabolic Pathways", which are scheduled for July 13-18, 2008, and July 12-17, 2009, at the University of New England in Biddeford, Maine. The broad and long-term goal of this conference is to foster a molecular level understanding of biological processes, including biochemical pathways and their associated catalysts. Our specific aim is to present a program of 36 speakers, 8 chosen from poster abstracts, describing recent advances in Natural Product Biosynthesis, New Approaches to Metabolic Pathways, Proteins on the Move, Advances in Medicinal Enzymology, Nucleic Acid Enzymology, Signal Transduction, Regulated Proteolysis and Frontiers in Enzymology. Afternoon poster sessions provide a venue for all attendees to present their work, providing junior investigators the opportunity to interact with senior investigators in the field. The significance of this proposal is that the Enzymes GRC serves as the touchstone for the community of researchers investigating the molecular mechanisms of biochemical reactions. The health-relatedness of this application derives from the fact that a molecular description of disease processes is indispensable for the design of chemotherapy.