Collaborative Pediatric Critical Care Research Network - Clinical Site

项目摘要/摘要-国立儿童医院 发现新的治疗方法来挽救生命和改善危重儿童的康复 疾病可能会对儿童、家庭和整个卫生保健系统产生深远影响。在过去 几十年来，通常来自一个中心或少数几个中心的研究导致了耐人寻味的假说 这可能会为许多情况带来好处。然而，全面测试这些假定的疗法已经 由于无法招收足够数量的受试者，动员足够训练有素的人员 进行研究，并获得足够的资源来充分回答这个问题。国立儿童医院(CNH) 热心加入新的协作式儿科重症监护网络(CPCCRN)，履行创新 脓毒症后多器官衰竭患儿的研究。 CNH为成为2004年开始的前三个CPCCRN周期的一部分而感到自豪。作为临床中心， 每年有超过4000名ICU入院，同时服务于华盛顿/马里兰州/弗吉尼亚州的多元化社区 在该地区，我们为招募受试者参加创新的临床研究做好了独特的准备。通过将来自我们的 中心，来自我们的辅助站点(里士满儿童医院[CHOR])和这个新的内部其他22个站点 CPCCRN将有足够数量的儿童可供入学，并确保 调查结果。我们为这个新项目带来了一支经验丰富的研究团队。我们的PI团队在研究方面很有经验， CNH的神经和心脏危重护理专家和领导者。在这些身份中，他们将确定和 支持青年调查人员参与CPCCRN活动，同时确保项目成功(S) 在CPCCRN内。私人投资主任一直深入参与初步研究，这些研究已导致 提出个体化用药治疗儿童多器官衰竭的研究。我们相信这本小说 这种方法最终将使这一领域跨过只能为此类患者提供“支持性”护理的障碍 并导致整体功能、生活质量和家庭功能的实质性改善。此外，我们 相信新的、资助的项目可以通过我们中心内部的调查人员纳入CPCCRN，以便进一步 儿科重症监护领域的进展。

PROJECT SUMMARY/ABSTRACT – Children’s National Hospital Discovery of new therapeutic approaches to save the lives and improve the recovery of children with critical illnesses can have profound effects on the child, the family and the overall health care system. In the past decades, studies – often from a single center or a small number of centers - have led to intriguing hypotheses that may result in benefits for a wide number of conditions. However, fully testing these putative therapies has been hampered by an inability to enroll adequate number of subjects, mobilize sufficient trained personnel to conduct the study and garner enough resources to fully answer the question. Children’s National Hospital (CNH) is enthusiastic to join the new Collaborative Pediatric Critical Care Network (CPCCRN) to perform the innovative studies for children with multiple organ failure after sepsis. CNH has been proud to be a part of the 3 previous CPCCRN cycles starting in 2004. As a clinical center with over 4000 ICU admissions each year while serving a diverse community in the Washington/Maryland/Virginia region, we stand uniquely poised to enroll subjects in innovative clinical studies. By including children from our center, from our ancillary site (Children’s Hospital of Richmond [CHoR]) and the other 22 sites within this new CPCCRN, sufficient numbers of children will be available for enrollment and ensure the generalizability of the findings. We bring an experienced research team to this new project. Our PI team is experienced at research, specialists in neurological and cardiac critical care and leaders at CNH. In these capacities, they will identify and support young investigators to participate in CPCCRN activities while also ensuring the success of the project(s) within CPCCRN. The PIs have been deeply involved with the preliminary studies that have led up to the proposed studies of personalized medicine to treat children with multiple organ failure. We believe this novel approach will finally advance the field past the hurdle of only being able to use “supportive” care for such patients and lead to substantial improvements in overall function, quality of life and family functioning. Moreover, we believe that new, funded projects can be brought into CPCCRN by investigators within our center to make further advances in the field of pediatric critical care.