Collaborative Pediatric Critical Care Research Network - Clinical Site

项目摘要/摘要——国立儿童医院 发现新的治疗方法来拯救生命并改善危重儿童的康复 疾病会对儿童、家庭和整个医疗保健系统产生深远影响。过去 几十年来，研究——通常来自一个中心或少数几个中心——得出了有趣的假设 这可能会给多种病症带来好处。然而，充分测试这些假定的疗法已经 由于无法招收足够数量的科目而受到阻碍，动员足够的训练有素的人员 进行研究并获得足够的资源来充分回答问题。国立儿童医院 (CNH) 热衷于加入新的协作儿科重症监护网络 (CPCCRN) 来执行创新 针对脓毒症后多器官衰竭儿童的研究。 CNH 很荣幸能够参与自 2004 年开始的前 3 个 CPCCRN 周期。 每年有超过 4000 名 ICU 入院，同时为华盛顿/马里兰/弗吉尼亚州的多元化社区提供服务 在该地区，我们处于独特的地位，可以招募受试者参加创新的临床研究。通过包括我们的孩子 中心，从我们的辅助站点（里士满儿童医院 [CHoR]）和这个新的其他 22 个站点 CPCCRN，将有足够数量的儿童可供入学，并确保该项目的普遍适用性 调查结果。我们为这个新项目带来了一支经验丰富的研究团队。我们的 PI 团队在研究方面经验丰富， 神经和心脏重症监护领域的专家以及 CNH 的领导者。以这些身份，他们将识别并 支持年轻研究者参与 CPCCRN 活动，同时确保项目的成功 CPCCRN 内。 PI 深入参与了初步研究，最终形成了 提出了治疗多器官衰竭儿童的个性化医疗研究。我们相信这部小说 该方法最终将推动该领域克服只能对此类患者使用“支持”护理的障碍 并导致整体功能、生活质量和家庭功能的实质性改善。此外，我们 相信我们中心的研究人员可以将新的资助项目带入 CPCCRN，以进一步取得进展 儿科重症监护领域的进展。

PROJECT SUMMARY/ABSTRACT – Children’s National Hospital Discovery of new therapeutic approaches to save the lives and improve the recovery of children with critical illnesses can have profound effects on the child, the family and the overall health care system. In the past decades, studies – often from a single center or a small number of centers - have led to intriguing hypotheses that may result in benefits for a wide number of conditions. However, fully testing these putative therapies has been hampered by an inability to enroll adequate number of subjects, mobilize sufficient trained personnel to conduct the study and garner enough resources to fully answer the question. Children’s National Hospital (CNH) is enthusiastic to join the new Collaborative Pediatric Critical Care Network (CPCCRN) to perform the innovative studies for children with multiple organ failure after sepsis. CNH has been proud to be a part of the 3 previous CPCCRN cycles starting in 2004. As a clinical center with over 4000 ICU admissions each year while serving a diverse community in the Washington/Maryland/Virginia region, we stand uniquely poised to enroll subjects in innovative clinical studies. By including children from our center, from our ancillary site (Children’s Hospital of Richmond [CHoR]) and the other 22 sites within this new CPCCRN, sufficient numbers of children will be available for enrollment and ensure the generalizability of the findings. We bring an experienced research team to this new project. Our PI team is experienced at research, specialists in neurological and cardiac critical care and leaders at CNH. In these capacities, they will identify and support young investigators to participate in CPCCRN activities while also ensuring the success of the project(s) within CPCCRN. The PIs have been deeply involved with the preliminary studies that have led up to the proposed studies of personalized medicine to treat children with multiple organ failure. We believe this novel approach will finally advance the field past the hurdle of only being able to use “supportive” care for such patients and lead to substantial improvements in overall function, quality of life and family functioning. Moreover, we believe that new, funded projects can be brought into CPCCRN by investigators within our center to make further advances in the field of pediatric critical care.