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Collaborative Pediatric Critical Care Research Network - Clinical Site

儿科重症监护协作研究网络 - 临床网站

基本信息

批准号：
10468855
负责人：
MICHAEL J BELL
金额：
$ 9.04万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-13 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10468855
关键词：
Acute Admission activity Affect Antibiotics Area Ascorbic Acid Biological Markers Brain Cardiac Chest Child Child Development Child Health Childhood Clinical Research Clinical Trials Collaborations Communities Contracts Critical Care Critical Illness Critically ill children Data Data Coordinating Center Delirium Development District of Columbia Enrollment Ensure Faculty Family Funding Goals Good Clinical Practice Guideline Adherence Health Healthcare Systems Hospitals Human Resources Hypoxemic Respiratory Failure Individual Inflammation Injury Institutes Institution Lead Maryland Measures Mechanics Medicine Morbidity - disease rate Multicenter Studies Multiple Organ Failure Neurologic Nitric Oxide Observational Study Organ Organ failure Outcome Oxygen Patient Care Patients Pediatric Hospitals Performance Personal Satisfaction Principal Investigator Procedures Protocols documentation Public Health Quality of life Randomized Controlled Trials Recovery Research Research Personnel Research Proposals Research Training Resources Resuscitation Scientist Sedation procedure Sepsis Sickle Cell Anemia Site Sleep Specialist Standardization Supportive care T cell regulation Talents Testing Training Traumatic Brain Injury Virginia Washington Work burden of illness career clinical care clinical center clinical research site design disability expectation experience functional outcomes functional status health related quality of life immunoregulation improved improved outcome innovation meetings member mortality novel strategies novel therapeutic intervention outcome prediction participant enrollment pediatric sepsis pediatric trauma pediatric traumatic brain injury personalized medicine research study skills success systematic review

项目摘要

PROJECT SUMMARY/ABSTRACT – Children’s National Hospital Discovery of new therapeutic approaches to save the lives and improve the recovery of children with critical illnesses can have profound effects on the child, the family and the overall health care system. In the past decades, studies – often from a single center or a small number of centers - have led to intriguing hypotheses that may result in benefits for a wide number of conditions. However, fully testing these putative therapies has been hampered by an inability to enroll adequate number of subjects, mobilize sufficient trained personnel to conduct the study and garner enough resources to fully answer the question. Children’s National Hospital (CNH) is enthusiastic to join the new Collaborative Pediatric Critical Care Network (CPCCRN) to perform the innovative studies for children with multiple organ failure after sepsis. CNH has been proud to be a part of the 3 previous CPCCRN cycles starting in 2004. As a clinical center with over 4000 ICU admissions each year while serving a diverse community in the Washington/Maryland/Virginia region, we stand uniquely poised to enroll subjects in innovative clinical studies. By including children from our center, from our ancillary site (Children’s Hospital of Richmond [CHoR]) and the other 22 sites within this new CPCCRN, sufficient numbers of children will be available for enrollment and ensure the generalizability of the findings. We bring an experienced research team to this new project. Our PI team is experienced at research, specialists in neurological and cardiac critical care and leaders at CNH. In these capacities, they will identify and support young investigators to participate in CPCCRN activities while also ensuring the success of the project(s) within CPCCRN. The PIs have been deeply involved with the preliminary studies that have led up to the proposed studies of personalized medicine to treat children with multiple organ failure. We believe this novel approach will finally advance the field past the hurdle of only being able to use “supportive” care for such patients and lead to substantial improvements in overall function, quality of life and family functioning. Moreover, we believe that new, funded projects can be brought into CPCCRN by investigators within our center to make further advances in the field of pediatric critical care.

项目概要/摘要-国立儿童医院发现新的治疗方法，以挽救生命，并改善儿童的恢复与关键疾病会对儿童、家庭和整个卫生保健系统产生深远的影响。过去几十年来，研究-通常来自单个中心或少数中心-已经导致了有趣的假设这可能导致对多种条件的益处。然而，全面测试这些假定的疗法，由于无法招募足够数量的受试者，动员足够的训练有素的人员，开展研究并收集足够的资源来充分回答这个问题。国立儿童医院（CNH）热衷于加入新的合作儿科重症监护网络（CPCCRN），以执行创新的脓毒症后多器官衰竭儿童的研究。 CNH很荣幸能参加2004年开始的前三个CPCCRN周期。作为临床中心，在华盛顿/马里兰州/弗吉尼亚州的多元化社区服务时，每年有超过4000名ICU住院患者在本地区，我们在招募创新临床研究受试者方面具有独特的优势。通过包括来自我们国家的儿童中心，从我们的辅助网站（里士满儿童医院[CHoR]）和其他22个网站在这个新的 CPCCRN，将有足够数量的儿童可供入组，并确保调查结果。我们为这个新项目带来了一支经验丰富的研究团队。我们的PI团队在研究方面经验丰富，神经和心脏重症监护专家和CNH的领导者。他们将以这些身份查明和支持年轻的研究人员参与CPCCRN的活动，同时确保项目的成功在CPCCRN中。PI已经深入参与了导致建议研究个性化药物治疗儿童多器官衰竭。我们相信这本小说这种方法将最终推动该领域超越只能对此类患者使用“支持性”护理的障碍并导致整体功能、生活质量和家庭功能的实质性改善。而且我们我相信，新的，资助的项目可以被我们中心内的研究人员带入CPCCRN，以进一步儿科重症监护领域的进展。