Pharmacokinetics of sedatives – Understanding a modifiable risk factor for pediatric delirium

镇静剂的药代动力学 — 了解小儿谵妄的可改变危险因素

基本信息

  • 批准号:
    10002250
  • 负责人:
  • 金额:
    $ 69.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Over the past decade, delirium – identified as an unexplained alteration in cognitive function as a result of another clinical condition – has become recognized as a public health emergency for adults with critical illnesses. In this patient population, delirium is associated with mortality, morbidity, increased length of hospital stays and increased health care costs. We have developed a delirium screening tool to assess delirium in children of all ages. This score, the Cornell Assessment of Pediatric Delirium, has been validated with several psychiatrists at Cornell University and is starting to be used as a part of clinical care. While the development of delirium is multifactorial, sedatives represent a modifiable risk factor for clinicians to consider. To date, there is no pharmacokinetic information to guide clinicians on which sedatives are linked to delirium development. Based on extensive preliminary evidence, we suspect that benzodiazepine-based sedation is related to delirium development and may be affected by drug clearance and serum concentrations. We will also determine if other commonly used narcotics and other agents are associated with delirium development independent of benzodiazepine effects. We will test these two specific aims in a multi-centered (n = 3) study with analysis done at the University of Pittsburgh and University of Buffalo.
项目总结/文摘

项目成果

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MICHAEL J BELL其他文献

MICHAEL J BELL的其他文献

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{{ truncateString('MICHAEL J BELL', 18)}}的其他基金

Improving Pediatric Brain Injury Outcomes Through Equitable Care Implementation
通过实施公平护理改善儿童脑损伤的结果
  • 批准号:
    10597474
  • 财政年份:
    2022
  • 资助金额:
    $ 69.16万
  • 项目类别:
Adding CTSI-CN COVID Data to the N3C
将 CTSI-CN COVID 数据添加到 N3C
  • 批准号:
    10300746
  • 财政年份:
    2021
  • 资助金额:
    $ 69.16万
  • 项目类别:
Collaborative Pediatric Critical Care Research Network - Clinical Site
儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10393851
  • 财政年份:
    2021
  • 资助金额:
    $ 69.16万
  • 项目类别:
Collaborative Pediatric Critical Care Research Network - Clinical Site
儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10248824
  • 财政年份:
    2021
  • 资助金额:
    $ 69.16万
  • 项目类别:
Collaborative Pediatric Critical Care Research Network - Clinical Site
儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10470936
  • 财政年份:
    2021
  • 资助金额:
    $ 69.16万
  • 项目类别:
Collaborative Pediatric Critical Care Research Network - Clinical Site
儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10670278
  • 财政年份:
    2021
  • 资助金额:
    $ 69.16万
  • 项目类别:
Collaborative Pediatric Critical Care Research Network - Clinical Site
儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10468855
  • 财政年份:
    2021
  • 资助金额:
    $ 69.16万
  • 项目类别:
Collaborative Pediatric Critical Care Research Network - Clinical Site
儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10667492
  • 财政年份:
    2021
  • 资助金额:
    $ 69.16万
  • 项目类别:
Pharmacokinetics of sedatives – Understanding a modifiable risk factor for pediatric delirium
镇静剂的药代动力学 — 了解小儿谵妄的可改变危险因素
  • 批准号:
    10222740
  • 财政年份:
    2019
  • 资助金额:
    $ 69.16万
  • 项目类别:
Pharmacokinetics of sedatives – Understanding a modifiable risk factor for pediatric delirium
镇静剂的药代动力学 — 了解小儿谵妄的可改变危险因素
  • 批准号:
    10453708
  • 财政年份:
    2019
  • 资助金额:
    $ 69.16万
  • 项目类别:

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确定急性呼吸衰竭和脓毒症患者在 ICU 与病房分诊后导致结局差异的患者亚组和护理流程
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