High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 1

HIV 病毒库的持续性和扰动的高清表征：项目 1

• 批准号: 10469111
• 负责人: Jonathan Li
• 金额: $ 45.8万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10469111
• 关键词: AIDS clinical trial group; Address; Aftercare; Atlases; Biological Assay; Biological Response Modifiers; CD4 Positive T Lymphocytes; Cells; Clinical; Clonal Expansion; Clone Cells; Communication; Disease remission; Environment; Future; Genetic Transcription; Goals; HIV; HIV-1; Individual; Inflammatory; Institutional Review Boards; Interruption; Intervention; Lead; Leadership; Maps; Mediator of activation protein; Membrane Proteins; Modeling; Participant; Pathway interactions; Persons; Population; Progress Reports; Proviruses; RNA; Research; Research Personnel; Resolution; Resources; Sampling; Services; T cell receptor repertoire sequencing; T-Lymphocyte; Techniques; Therapeutic Intervention; Transcriptional Activation; Viral; Viremia; Virus; Withholding Treatment; Work; antiretroviral therapy; cohort; cytokine; data exchange; design; experience; genome-wide; insight; integration site; material transfer agreement; meetings; multiple omics; novel; novel therapeutics; patient population; programs; protein expression; sample collection; transcriptome; viral rebound

SUMMARY The primary goal of this Core is to administer the resources, both financial and participant samples, needed for the successful completion of the Project and Core research aims. Specifically, this core will provide the following services: 1) Provide administrative and budgetary oversight of the Projects and Cores; 2) Plan and arrange for regular team Program leadership meetings and Program scientific meetings; 3) Facilitate the communication and exchange of data between Projects and Cores; 4) Produce and submit annual progress reports, and the final progress report; 5) Assist in the speedy execution of institutional review board applications and material transfer agreements; and 6) Work closely with outside collaborators and the AIDS Clinical Trials Group to coordinate the identification, receipt, and storage of participant samples. In addition, this Core will work closely with outside collaborators and the AIDS Clinical Trials Group to coordinate the identification, receipt, and storage of participant samples. The Administrative and Sample Collection Core will facilitate institutional regulatory approval and material transfer agreements.

总结 该核心的主要目标是管理财务和参与者样本所需的资源， 项目和核心研究目标的顺利完成。具体而言，该核心将提供 以下服务：1）提供项目和核心的行政和预算监督; 2）计划和 安排定期的团队计划领导会议和计划科学会议; 3）促进 项目和核心之间的沟通和数据交换; 4）生成并提交年度进度 5）协助迅速执行机构审查委员会的工作 申请和材料转让协议;以及6）与外部合作者和艾滋病 临床试验组协调参与者样本的识别、接收和储存。此外，本发明还提供了一种方法， 该中心将与外部合作者和艾滋病临床试验小组密切合作， 参与者样本的识别、接收和储存。管理和样本采集核心将 促进机构监管批准和材料转让协议。