Imaging Biomarker Core

成像生物标志物核心

• 批准号: 10469452
• 负责人: EMILY J ROGALSKI
• 金额: $ 77.81万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10469452
• 关键词: Achievement; Aging; Alzheimer' s Disease; Area; Autopsy; Biological Markers; Biomedical Engineering; Clinical; Cognitive; Collaborations; Data; Data Set; Databases; Dementia; Differential Diagnosis; Discipline of Nuclear Medicine; Disease; Ensure; Extramural Activities; Functional Imaging; Funding; Future; Goals; Heterogeneity; High Performance Computing; Hospitals; Image; Impaired cognition; Individual; Infrastructure; Lead; Magnetic Resonance Imaging; Methods; Mission; National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; Natural History; Output; PET/CT scan; Participant; Phase; Phenotype; Positron-Emission Tomography; Process; Radiology Specialty; Records; Research; Research Personnel; Research Project Grants; Route; Running; Scanning; Structure; Translational Research; Universities; amnestic mild cognitive impairment; clinical diagnostics; cluster computing; cohort; data archive; data management; data resource; falls; imaging biomarker; imaging modality; improved; molecular imaging; multimodal neuroimaging; neuroimaging; quality assurance; recruit; statistics; tool; training opportunity

PROJECT SUMMARY - IMAGING BIOMARKER CORE The Northwestern ADRC Imaging Biomarker Core has the long-term goal to characterize all eligible Clinical Core participants with state-of-the-art structural, functional, and molecular imaging and curate these data for use in future projects. The Northwestern ADRC Clinical Core currently maintains a cohort of over 500 participants. Approximately half of the Clinical Core Participants receive systematic MR imaging funded by R01s from NIA, NINDS, and NIDCD. During the last cycle, the Imaging Biomarker Core increased imaging coverage from approximately 50% of the Clinical Core cohort to nearly 70%. For the next cycle, it will acquire and process structural, functional, and molecular imaging on additional Clinical Core participants who are not covered by other research grants and who are targeted for relevant collaborative studies. We will use advanced acquisition and analysis methods and ensure these data are integrated with other variables within an infrastructure that supports intramural and extramural collaborations and provides rich opportunities for training. The Imaging Biomarker Core is highly interconnected with the other Northwestern ADRC Cores in a manner that enhances the missions of NAPA and the NIA. It will be guided by the following goals: 1) Acquire systematic and multimodal neuroimaging (MR, PET) on Clinical Core participants who lack these biomarkers and who are eligible/recruited for collaborative studies we support. To this end, Clinical Core participants including cognitively healthy controls, individuals with amnestic mild cognitive impairment (aMCI), and individuals with AD/ADRD will be scanned with advanced PET and MR imaging modalities. 2) Curate and share integrated imaging datasets on Clinical Core participants, which will serve intramural and extramural collaborations including REC trainee projects. This aim will draw upon a mature institutional computing structure to run pipelines for quality assurance, processing, and analysis of imaging data. The resulting imaging outputs will be incorporated with clinical and post-mortem data in our unified ADRC NeuroFiles database developed in collaboration with the Data Management and Statistics Core. The infrastructure of the Imaging Biomarker Core includes two research-dedicated 3T Siemens MR magnets at Northwestern’s Center for Translational Imaging (CTI) and a PET/CT scanner at Northwestern Memorial Hospital. Data are directly routed from the scan console to the Northwestern University Neuroimaging Data Archive (NUNDA), where quality assurance and analysis tools are launched with the support of a high- performance computing cluster called QUEST. Collectively, these data will enhance the clinical and diagnostic characterization of each Clinical Core participant and will be made available to approved intramural and national collaborators including NACC. All phases of this proposal will offer unique opportunities for the training of junior investigators in areas related to imaging and translational research.

项目总结-成像生物标记物核心 西北ADRC成像生物标志物核心的长期目标是表征所有符合条件的临床 核心参与者拥有最先进的结构，功能和分子成像，并策划这些数据， 用于未来项目。西北ADRC临床核心目前维持着一个超过500人的队列 参与者大约一半的临床核心参与者接受由以下机构资助的系统性MR成像： 来自NIA、NINDS和NIDCD的R 01。在最后一个周期中，成像生物标志物核心增加了成像 覆盖率从约50%的临床核心队列提高到近70%。在下一个周期，它将获得 并对其他临床核心参与者进行结构、功能和分子成像， 受其他研究赠款资助，并以相关合作研究为对象。我们将使用 先进的采集和分析方法，并确保这些数据与其他变量集成在一个 基础设施，支持校内和校外合作，并提供丰富的机会， 训练成像生物标志物核心与其他西北ADRC核心高度互连， 加强国家适应行动方案和国家执行机构任务的方式。它将以下列目标为指导： 1)对缺乏系统和多模式神经成像（MR、PET）的临床核心参与者进行采集 生物标志物和谁有资格/招募我们支持的合作研究。为此，临床核心 参与者包括认知健康对照组、遗忘型轻度认知障碍个体 患有AD/ADRD的个体将使用高级PET和MR成像模式进行扫描。 2)策划和共享临床核心参与者的集成成像数据集， 和校外合作，包括REC实习生项目。这一目标将利用一个成熟的机构 计算结构，以运行用于质量保证、处理和分析成像数据的管道。的 由此产生的成像输出将与我们统一的ADRC中的临床和尸检数据相结合 NeuroFiles数据库与数据管理和统计核心合作开发。 成像生物标志物核心的基础设施包括两个研究专用的3 T西门子MR磁体， 西北大学转化成像中心（CTI）和西北纪念医院的PET/CT扫描仪 医院数据直接从扫描控制台发送到西北大学神经成像数据中心。 档案馆（国家裁军事务厅），在高级别的支助下推出质量保证和分析工具， 性能计算集群称为QUEST。总的来说，这些数据将增强临床和诊断能力， 每名临床核心参与者的特征，并将提供给批准的内部和 包括NACC在内的国家合作者。本提案的所有阶段都将为培训提供独特的机会， 在与成像和转化研究相关的领域的初级研究人员。