Data Management and Statistical Core

数据管理与统计核心

• 批准号: 10469449
• 负责人: Firas Hazem Wehbe
• 金额: $ 34.91万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10469449
• 关键词: Address; Alzheimer' s Disease; Applications Grants; Applied Research; Area; Automation; Biometry; Cells; Clinical; Clinical Sciences; Collaborations; Consultations; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Education; Equipment and supply inventories; Extramural Activities; Generations; Goals; Grant; Grant Review; Image; Immunofluorescence Immunologic; Informatics; Infrastructure; Institutes; Investigation; Journals; Leadership; Linear Models; Methods; Microglia; Modeling; Monitor; Paper; Pathologic; Patients; Play; Postdoctoral Fellow; Process; Proteins; Published Comment; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resources; Review Committee; Role; Secure; Signal Transduction; Statistical Data Interpretation; Statistical Methods; Structure; Time; Translational Research; Universities; Writing; base; biomedical informatics; cell type; data management; design; digital; education research; flexibility; follow-up; graduate student; imaging biomarker; innovation; interest; neuropathology; novel; operation; outreach; pre-doctoral; protein TDP-43; recruit; research and development; response; statistics; tool; training project; transmission process

PROJECT SUMMARY - DATA MANAGEMENT AND STATISTICAL CORE The Data Management and Statistics (DMS) Core has an essential role in all activities of the Northwestern ADRC, whereby all information generated through ADRC operations is stored, integrated and shared in a systematic fashion; studies are provided with design expertise, and research results are analyzed and presented optimally. During the past 5 years, the Northwestern ADRC has devoted considerable resources to its DMS Core in ways that have enhanced its impact on intramural activities and streamlined interactions with NACC and extramural collaborations. During the upcoming cycle, the DMS Core will be guided by three goals: 1) To maintain an integrated and flexible state-of-the-art relational and secure database that provides efficient access to subject-based data for approved research projects and for transmission to NACC. 2) To provide biostatistics expertise in research design and data analysis for all ADRC investigators, including fellows, graduate students and Development Project Grant applicants. 3) To apply and develop innovative biostatistical approaches designed to address new developments within the Northwestern ADRC. The DMS Core has undergone a profound transformation over the last five years in response to the evolving needs of the Northwestern ADRC, NIA, NACC, and our many research collaborators. In collaboration with the Northwestern University Clinical and Translational Sciences Institute (NUCATS), the DMS Core established a state-of-the-art database with a robust set of tools that assist in the capture, curation, storage, searching, sharing, transferring and analysis of data sets generated by all components of the ADRC. In addition, the DMS Core participates in the design and interpretation of all ADRC research projects with a quantitative component. Statisticians provide expertise in the generation of hypotheses and analyses of the results and participate in the writing of grant applications as needed, formulating and writing the power calculations, setting up data collection tools, monitoring data collection, and performing statistical analyses. The DMS Core will also apply and develop innovative biostatistical approaches designed to address new research developments within the Northwestern ADRC. Statistical consultation is available to all senior and junior investigators, postdoctoral fellows, and predoctoral graduate students.

项目摘要 - 数据管理和统计核心 数据管理和统计 (DMS) 核心在西北大学的所有活动中发挥着至关重要的作用 ADRC，通过 ADRC 操作生成的所有信息都存储、集成和共享在一个 系统化的时尚；研究提供设计专业知识，并对研究结果进行分析和 最佳呈现。近5年来，西北地区防灾研究中心投入了大量资源 其 DMS 核心增强了对校内活动的影响并简化了与 NACC 和校外合作。在下一个周期中，DMS Core 将遵循三个目标： 1) 维护一个集成且灵活的最先进的关系型安全数据库，该数据库提供 有效获取经批准的研究项目的基于主题的数据并传输至 NACC。 2) 为所有 ADRC 研究人员提供研究设计和数据分析方面的生物统计学专业知识， 包括研究员、研究生和发展项目补助金申请人。 3）应用和开发创新的生物统计方法，旨在解决领域内的新发展 西北 ADRC。 DMS Core 在过去五年中经历了深刻的变革，以应对不断发展的变化 西北 ADRC、NIA、NACC 以及我们众多研究合作者的需求。与合作 西北大学临床与转化科学研究所 (NUCATS)，DMS 核心建立了 最先进的数据库，具有一套强大的工具，可帮助捕获、管理、存储、搜索、 共享、传输和分析 ADRC 所有组成部分生成的数据集。此外，DMS Core 参与所有 ADRC 研究项目的设计和解释，其中包括定量部分。 统计学家提供假设生成和结果分析方面的专业知识，并参与 根据需要撰写资助申请，制定和编写功率计算，设置数据 收集工具、监控数据收集并执行统计分析。 DMS Core 也将适用 并开发创新的生物统计方法，旨在解决该领域的新研究进展 西北ADRC。统计咨询面向所有高级和初级研究人员、博士后 研究员和博士前研究生。