Data Management and Statistical Core

项目摘要-数据管理和统计核心 数据管理和统计（DMS）核心在西北大学的所有活动中发挥着重要作用。 ADRC，通过ADRC操作生成的所有信息都存储、集成和共享在一个 系统的方式;研究提供了设计专业知识，研究结果进行了分析， 最佳呈现。在过去的5年里，西北ADRC投入了大量的资源， 其DMS核心的方式已经增强了其对内部活动的影响，并简化了与 NACC和校外合作。在即将到来的周期中，DMS核心将以三个目标为指导： 1)维护一个集成的、灵活的、最先进的关系型安全数据库， 有效地访问基于主题的数据，用于批准的研究项目和传输到NACC。 2)为所有ADRC研究者提供研究设计和数据分析方面的生物统计学专业知识， 包括研究员、研究生和发展项目补助金申请人。 3)应用和开发创新的生物统计方法，以应对 西北ADRC DMS核心在过去五年中经历了深刻的变革，以应对不断变化的 西北ADRC，NIA，NACC和我们的许多研究合作者的需求。联同 西北大学临床和转化科学研究所（NUCATS），DMS核心建立了一个 最先进的数据库，具有一组强大的工具，可帮助捕获、管理、存储、搜索 共享、传输和分析ADRC所有组件生成的数据集。此外，DMS 核心参与设计和解释所有ADRC研究项目的定量组成部分。 统计学家在提出假设和分析结果方面提供专门知识，并参与 根据需要编写赠款申请，制定和编写功率计算，建立数据 收集工具、监测数据收集和进行统计分析。DMS核心也将适用于 并开发创新的生物统计方法，旨在解决新的研究发展， 西北ADRC统计咨询提供给所有高级和初级研究人员，博士后 研究员和博士前研究生。

PROJECT SUMMARY - DATA MANAGEMENT AND STATISTICAL CORE The Data Management and Statistics (DMS) Core has an essential role in all activities of the Northwestern ADRC, whereby all information generated through ADRC operations is stored, integrated and shared in a systematic fashion; studies are provided with design expertise, and research results are analyzed and presented optimally. During the past 5 years, the Northwestern ADRC has devoted considerable resources to its DMS Core in ways that have enhanced its impact on intramural activities and streamlined interactions with NACC and extramural collaborations. During the upcoming cycle, the DMS Core will be guided by three goals: 1) To maintain an integrated and flexible state-of-the-art relational and secure database that provides efficient access to subject-based data for approved research projects and for transmission to NACC. 2) To provide biostatistics expertise in research design and data analysis for all ADRC investigators, including fellows, graduate students and Development Project Grant applicants. 3) To apply and develop innovative biostatistical approaches designed to address new developments within the Northwestern ADRC. The DMS Core has undergone a profound transformation over the last five years in response to the evolving needs of the Northwestern ADRC, NIA, NACC, and our many research collaborators. In collaboration with the Northwestern University Clinical and Translational Sciences Institute (NUCATS), the DMS Core established a state-of-the-art database with a robust set of tools that assist in the capture, curation, storage, searching, sharing, transferring and analysis of data sets generated by all components of the ADRC. In addition, the DMS Core participates in the design and interpretation of all ADRC research projects with a quantitative component. Statisticians provide expertise in the generation of hypotheses and analyses of the results and participate in the writing of grant applications as needed, formulating and writing the power calculations, setting up data collection tools, monitoring data collection, and performing statistical analyses. The DMS Core will also apply and develop innovative biostatistical approaches designed to address new research developments within the Northwestern ADRC. Statistical consultation is available to all senior and junior investigators, postdoctoral fellows, and predoctoral graduate students.