Optimizing an mHealth intervention to improve uptake and adherence of the HIV pre-exposure prophylaxis (PrEP) in vulnerable adolescents and emerging adults
优化移动医疗干预措施,以提高弱势青少年和新生成年人对 HIV 暴露前预防 (PrEP) 的接受度和依从性
基本信息
- 批准号:10469457
- 负责人:
- 金额:$ 17.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-13 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAcquired Immunodeficiency SyndromeAddressAdherenceAdultAdvisory CommitteesAffectAgeAsiaAwarenessBiological MarkersCenters for Disease Control and Prevention (U.S.)ClinicClinicalCommunitiesComplexCounselingCountryDevelopmentDrug usageEmploymentEpidemicFaceGenderGender IdentityHIVHIV InfectionsHIV SeronegativityHIV SeroprevalenceHIV/STDHealthHealth PersonnelHealth systemHigh PrevalenceIndividualInterventionInterviewJointsMentorsMethodsModelingMonitorMotivationPatient RecruitmentsPatternPersonsPhasePopulationPrevalencePrevention strategyPreventive serviceProcessProtocols documentationProviderRandomizedRecommendationResearchRiskRisk-TakingSelf ManagementSexual HealthSystemTechnologyTestingText MessagingThailandTraining ProgramsTreatment EfficacyWorkacceptability and feasibilityagedbasedesigneffective interventionefficacy trialemerging adultemerging adulthoodfeasibility researchgroup interventionhigh risk behaviorhigh risk populationimprovedinfection rateinnovationintervention programmHealthmobile applicationmobile computingmotivational enhancement therapymultiphase optimization strategyparticipant retentionpost interventionpre-exposure prophylaxispreventrecruitresponsesatisfactionscale upsexside effectsocial stigmasubstance usesuccesstherapy designtransgender womentransmission processuptakeusabilityvulnerable adolescentwebinar
项目摘要
Transgender women (TGW), particularly young TGW (ages 18-29), are among the fastest growing HIV+
populations worldwide with HIV prevalence rates of 15-28%. Thailand has the highest adult HIV
seroprevalence in Asia, with high prevalence rates of HIV infection among TGW (18%). Despite their risk, few
interventions have targeted young TGW. Effective developmentally- and culturally-tailored interventions are
needed to prevent HIV transmission in this high-risk population. Widespread technology offers opportunities
for innovative mobile (mHealth) interventions. Pre-exposure prophylaxis (PrEP) is an efficacious HIV
prevention strategy recommended by the CDC and WHO for at-risk individuals, including HIV-negative TGW.
PrEP is highly effective when taken as prescribed, but PrEP uptake and adherence have been low, with high
discontinuation rates among TGW. To address these challenges, we propose to develop and pilot a multi-
component, technology-based intervention to promote PrEP usage. We will adapt an existing two-session,
technology-delivered, Motivational Interviewing intervention to focus on PrEP use in young Thai TGW,
resulting in the Motivational Enhancement System for PrEP Uptake and Adherence (MES-PrEP). We will also
refine and enhance “YaCool,” a mobile app with integrated text messaging developed and used clinically by our
Thai team, to develop “enhanced YaCool” for TGW self-management of gender/sexual health (including PrEP).
Our primary aim is to develop and assess preliminary efficacy of the resulting mHealth intervention. We will
utilize a Multiphase Optimization Strategy (MOST) to identify the most effective intervention component or
combination of components to address PrEP usage in this population. The proposed study includes 2 phases
corresponding to the R21 and R33 study periods. Phase IA (R21) includes qualitative interviews with key
stakeholders to explore barriers and facilitators of PrEP usage through thematic analysis to inform intervention
adaptation. Phase IB (R21) consists of adapting and beta testing of MES-PrEP and enhanced YaCool for
functionality and feasibility using a community advisory board of HIV-negative Thai TGW. In Phase II (R33),
we will conduct a MOST design-based trial to evaluate the feasibility, acceptability, and preliminary efficacy of
MES-PrEP and YaCool. Eighty HIV-negative young TGW who are on PrEP and 80 young TGW who are not
starting PrEP will be randomized to four experimental conditions: 1) Standard PrEP Counseling (SPC, control),
2) MES-PrEP + SPC, 3) enhanced YaCool + SPC, and 4) MES-PrEP + enhanced YaCool + SPC. Feasibility and
acceptability of the intervention will be assessed through usage patterns and the System Usability Scale.
Preliminary impact will be assessed by evaluating the proportion of PrEP initiation and level of adherence to
PrEP. TGW will complete assessments at baseline and 1, 3, 6, 9, and 12 months post-intervention. Biomarkers
of adherence to PrEP and HIV/STI will be collected. Upon project completion, we will have an optimized
mHealth intervention to support TGW using PrEP which will be ready for testing in a larger efficacy trial.
变性女性(TGW),特别是年轻的TGW(18-29岁),是增长最快的艾滋病毒感染者之一
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Optimizing an mHealth Intervention to Improve Uptake and Adherence to HIV Pre-exposure Prophylaxis in Young Transgender Women: Protocol for a Multi-Phase Trial.
- DOI:10.2196/37659
- 发表时间:2022-05-19
- 期刊:
- 影响因子:1.7
- 作者:MacDonell, Karen Kolmodin;Wang, Bo;Phanuphak, Nittaya;Janamnuaysook, Rena;Srimanus, Peevara;Rongkavilit, Chokechai;Naar, Sylvie
- 通讯作者:Naar, Sylvie
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Karen MacDonell其他文献
Karen MacDonell的其他文献
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{{ truncateString('Karen MacDonell', 18)}}的其他基金
Adapting mHealth interventions to improve self-management of HIV and substance use among emerging adults in Zambia
采用移动医疗干预措施,改善赞比亚新兴成年人对艾滋病毒和药物滥用的自我管理
- 批准号:
10813460 - 财政年份:2023
- 资助金额:
$ 17.56万 - 项目类别:
Optimizing an mHealth intervention to improve uptake and adherence of the HIV pre-exposure prophylaxis (PrEP) in vulnerable adolescents and emerging adults
优化移动医疗干预措施,以提高弱势青少年和新生成年人对艾滋病毒暴露前预防 (PrEP) 的接受度和依从性
- 批准号:
10311830 - 财政年份:2021
- 资助金额:
$ 17.56万 - 项目类别:
Optimizing an mHealth intervention to improve uptake and adherence of the HIV pre-exposure prophylaxis (PrEP) in vulnerable adolescents and emerging adults
优化移动医疗干预措施,以提高弱势青少年和新生成年人对 HIV 暴露前预防 (PrEP) 的接受度和依从性
- 批准号:
10912991 - 财政年份:2021
- 资助金额:
$ 17.56万 - 项目类别:
SHARE Program: Innovations in Translational Behavioral Science to Improve Self-management of HIV and Alcohol Reaching Emerging adults
SHARE 计划:转化行为科学创新,以改善新兴成年人对艾滋病毒和酒精的自我管理
- 批准号:
10304691 - 财政年份:2021
- 资助金额:
$ 17.56万 - 项目类别:
SHARE Program: Innovations in Translational Behavioral Science to Improve Self-management of HIV and Alcohol Reaching Emerging adults
SHARE 计划:转化行为科学创新,以改善新兴成年人对艾滋病毒和酒精的自我管理
- 批准号:
10678982 - 财政年份:2021
- 资助金额:
$ 17.56万 - 项目类别:
Multi-component technology intervention for African American emerging adults with asthma
针对非洲裔美国新兴成人哮喘患者的多成分技术干预
- 批准号:
9158851 - 财政年份:2016
- 资助金额:
$ 17.56万 - 项目类别:
Multi-component technology intervention for African American emerging adults with asthma
针对非洲裔美国新兴成人哮喘患者的多成分技术干预
- 批准号:
9753332 - 财政年份:2016
- 资助金额:
$ 17.56万 - 项目类别:
Development of an MI Implementation Intervention in Adolescent HIV Care Settings
在青少年艾滋病毒护理环境中制定 MI 实施干预措施
- 批准号:
8990069 - 财政年份:2015
- 资助金额:
$ 17.56万 - 项目类别:
Multi-component technology intervention for minority emerging adults with asthma
针对少数新兴成人哮喘患者的多成分技术干预
- 批准号:
8399080 - 财政年份:2011
- 资助金额:
$ 17.56万 - 项目类别:
Multi-component technology intervention for minority emerging adults with asthma
针对少数新兴成人哮喘患者的多成分技术干预
- 批准号:
8244143 - 财政年份:2011
- 资助金额:
$ 17.56万 - 项目类别:
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