SHARE Program: Innovations in Translational Behavioral Science to Improve Self-management of HIV and Alcohol Reaching Emerging adults

SHARE 计划：转化行为科学创新，以改善新兴成年人对艾滋病毒和酒精的自我管理

• 批准号: 10304691
• 负责人: Karen MacDonell
• 金额: $ 142.89万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304691
• 关键词: AIDS/HIV problem; Address; Adult; Age; Alcohol consumption; Alcohols; Basic Behavioral Science; Behavior; Behavior Therapy; Behavioral; Behavioral Sciences; Behavioral trial; Big Data; Chronic Disease; Communities; Competence; Data Science Core; Decision Making; Development; Disease Progression; Elderly; Electronic Health Record; Ensure; Epidemic; Face; Feedback; Florida; Foundations; Goals; HIV; HIV Infections; HIV diagnosis; Health; Individual; Intervention; Life; Life Style; Link; Literature; Mental Health; Methods; Modeling; Monitor; Motivation; Neurocognition; Outcome; Pharmaceutical Preparations; Phase; Physical activity; Problem Solving; Program Research Project Grants; Psychological reinforcement; Public Health; Research; Research Project Grants; Risk; Risk Behaviors; Risk-Taking; Role; Self Management; Self-control as a personality trait; Sleep; Stress; Substance abuse problem; Technology; Testing; Tobacco; Translating; Translations; United States; United States National Institutes of Health; Viral; Viral Load result; Work; Youth; age group; alcohol comorbidity; alcohol monitoring; community engagement; community partnership; comorbidity; comparative effectiveness trial; efficacious intervention; emerging adult; emerging adulthood; expectation; improved; innovation; intervention program; new technology; physical conditioning; programs; psychosocial; recruit; scale up; secondary analysis; skills; social; social stigma; substance use; symptom management; symptom treatment; therapy design; therapy development; translational pipeline; translational study; transmission process; treatment as prevention

SHARE P01 ABSTRACT The purpose of the SHARE P01 research program project is to address HIV and alcohol use around three themes; 1) Emerging adulthood (ages 18 -29); 2) Self-management of HIV and alcohol; and 3) Translational behavioral science. Emerging adulthood is a developmental stage marked by significant change in social roles, expectations as a new adult, and increased responsibilities. It is also marked by poor HIV self- management and increased alcohol use. Emerging adults with HIV (hereafter called young people living with HIV; YPLWH) may face even more challenges given intersectional stigma. This age group continues to have very high rates of new HIV infections. Interventions designed specifically for the unique developmental challenges of emerging adults are needed, yet emerging adults are often included with older adults in intervention programs. The concept of self-management emerged concurrently within both the substance abuse and chronic illness literatures, and fits well with the developmental challenges of emerging adulthood. Self-management, a framework we have utilized in our work with YPLWH, refers to the ability to manage symptoms, treatments, lifestyle changes, and consequences of health conditions. Current research now identifies individual-level self-management skills such as self-control, decision-making, self-reinforcement, and problem solving as that protect against substance use and improve other health outcomes and can be embedded in the Information-Motivation-Behavioral Skills model. Although we have conducted multiple studies with YPLWH, only one intervention to date (Healthy Choices conducted by our team) improved both alcohol use and viral suppression in YPLWH in large trials. The goal of the SHARE P01 is to utilize advances in translational behavioral science to optimize behavioral interventions and define new developmentally- and culturally-appropriate intervention targets to improve self-management of alcohol and HIV in YPLWH. We will focus our efforts in Florida, a state hardest hit by the HIV epidemic but with a particularly strong academic- community partnership to support translation. We have assembled research teams to conduct self- management studies across the translational spectrum to address self-management and improve alcohol use and viral suppression (and thereby reduce transmission) in diverse YPLWH in Florida. The P01 will consist of three research projects (DEFINE, ENGAGE, and SUSTAIN), representing different stages on the translational spectrum and targeting different core competencies, supported by two cores (Community Engagement Core and Data Science Core). If successful, the SHARE P01 has the potential to greatly advance programs promoting self-management of HIV and alcohol use among a particularly vulnerable, but under-researched group, emerging adults living with HIV. SHARE also has a high potential for scale-up and implementation beyond Florida and across the United States.

分享P01摘要 SHARE P01研究项目的目的是解决艾滋病毒和酒精使用问题， 主题; 1）成年初显期（18 - 29岁）; 2）艾滋病毒和酒精的自我管理; 3）翻译 行为科学成年初显期是一个发展阶段，标志着社会的重大变化， 角色，作为一个新的成年人的期望，以及增加的责任。它也被标记为艾滋病毒自我差- 管理和增加酒精使用。新成年艾滋病毒感染者（以下简称年轻人） 艾滋病毒; YPLWH）可能面临更多的挑战，因为交叉的耻辱。这个年龄段的人 新的艾滋病毒感染率非常高。专门为独特的发展性 新成年人的挑战是必要的，但新成年人往往包括与老年人， 干预方案。自我管理的概念同时出现在这两个实质性问题中， 虐待和慢性疾病的文献，并符合新兴的成年人的发展挑战。 自我管理是我们在与YPLWH合作中使用的一个框架，指的是管理能力 症状、治疗、生活方式改变和健康状况的后果。目前的研究 识别个人层面的自我管理技能，如自我控制，决策，自我强化， 解决问题，因为这可以防止物质使用和改善其他健康结果， 信息-动机-行为技能模型。虽然我们已经进行了多次 与YPLWH的研究，只有一个干预迄今（健康的选择，由我们的团队进行）改善两者 酒精使用和病毒抑制在YPLWH的大型试验。SHARE P01的目标是利用先进技术 在转化行为科学，以优化行为干预和定义新的发展-和 在青年、艾滋病毒携带者和艾滋病患者中，制定文化上适当的干预目标，以改善酒精和艾滋病毒的自我管理。我们将 把我们的努力集中在佛罗里达，一个受艾滋病毒流行影响最严重的州，但有一个特别强大的学术- 社区合作伙伴关系，以支持翻译。我们组建了研究小组， 跨翻译范围的管理研究，以解决自我管理和改善酒精使用 和病毒抑制（从而减少传播）在不同的YPLWH在佛罗里达。P01将包括 三个研究项目（定义，参与，和持续），代表不同阶段的翻译 范围和针对不同的核心能力，由两个核心（社区参与核心）支持 数据科学核心（Data Science Core）如果成功，SHARE P01有可能大大推进项目 在特别脆弱但研究不足的人群中促进艾滋病毒和酒精使用的自我管理 新成年艾滋病毒感染者。SHARE还具有很大的推广和实施潜力 在佛罗里达和整个美国。