Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with Asthma

室内超细颗粒物暴露与哮喘儿童呼吸系统发病率、炎症和氧化应激之间的关系

• 批准号: 10470611
• 负责人: EMILY BRIGHAM
• 金额: $ 16.37万
• 依托单位: UNIVERSITY OF BRITISH COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-10 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10470611
• 关键词: Acute; Adult; Adult asthma; Affect; Air Pollution; Albuterol; Alveolus; Area; Asthma; Attenuated; Award; Baltimore; Biolectric Impedance; Biological; Biological Markers; Blood Circulation; Body mass index; Caliber; Cell membrane; Characteristics; Child; Childhood; Childhood Asthma; Chronic; Cities; Clinical Trials Design; Critical Care; Data; Development; Diet; Dietary intake; Dose; Environment; Environmental Exposure; Erythrocytes; Exposure to; Fatty Acids; Fatty acid glycerol esters; Foundations; Funding; Future; Growth; Health; Health Benefit; Heating; Home; Home environment; Human; Incidence; Individual; Indoor Air Pollution; Indoor environment; Inflammation; Inflammatory; Infrastructure; Intake; Intervention; Investigation; Leadership; Link; Literature; Low Income Population; Low income; Lung; Lung diseases; Measurement; Measures; Mediation; Medicine; Metabolic; Metabolism; Methods; Minority; Modification; Monitor; Morbidity - disease rate; Nasal Epithelium; Non obese; Nutritional; Obesity; Omega-3 Fatty Acids; Outcome; Oxidative Stress; Parents; Participant; Particulate Matter; Patient Self-Report; Penetration; Play; Population; Positioning Attribute; Predisposition; Public Health Schools; Research; Research Personnel; Resources; Respiratory Disease; Respiratory Tract Infections; Risk Factors; Role; Serum; Source; Spirometry; Surface; Symptoms; Time; Training; Ultrafine; Unhealthy Diet; United States; United States National Institutes of Health; Universities; Work; airway inflammation; asthma inhaler; base; biological adaptation to stress; career; coarse particles; cooking; dietary; environmental tobacco smoke; epidemiology study; experience; fine particles; health assessment; indoor exposure; inner city; interest; medical schools; minority children; mortality; novel; obesity in children; operation; particle; particle exposure; patient oriented; pollutant; portability; professor; pulmonary function; residence; respiratory; respiratory health; respiratory morbidity; response; skills; systemic inflammatory response; ultrafine particle; ventilation

Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with Asthma. Particulate matter (PM) is a criteria pollutant, and exposures have been linked with acute and chronic health effects, including respiratory morbidity and mortality. The smallest form of PM, ultrafine PM (UFP), enters and disperses freely in the lungs, and can translocate into the bloodstream. Because of their small size, UFPs have an enormously large surface area:particle mass ratio and carry adsorbed toxic contaminants known to incite inflammatory and oxidative stress responses. They are hypothesized to be among the most harmful components of PM to human health, and yet few epidemiologic investigations have been completed due to limitations in monitoring capabilities only recently overcome. Furthermore, the sources of these particles are often unique, and indoor exposures (i.e. cooking, heating, environmental tobacco smoke) contribute heavily to individual exposure. Dr. Brigham, Assistant Professor in Pulmonary and Critical Care Medicine at Johns Hopkins University, has a strong interest in the effects of these particles on respiratory disease. She has extensive research experience in epidemiologic studies of asthma health and metabolic risk factors for asthma morbidity in both adult and pediatric populations, and conducts her research within a group combining resources from the Johns Hopkins School of Medicine and adjacent Bloomberg School of Public Health with the expertise to support indoor UFP monitoring. Dr. Brigham's proposal seeks to define the impact of indoor UFP exposure on children with asthma in Baltimore City, a uniquely susceptible population with a historically disproportionate burden of indoor air pollution and more than twice the national average of prevalent asthma. She proposes to investigate: (Aim 1) the effects of UFP exposure on pediatric asthma symptoms, lung function, and rescue-inhaler use, (Aim 2) the effects of UFP exposure on airway and systemic markers of oxidative stress and inflammation, and (Aim 3) mediation of the effects of UFP exposure on asthma health by additional modifiable metabolic factors known to affect response to larger PM: adiposity and dietary intake of omega-3 fatty acids. This award will not only provide an outstanding training vehicle for Dr. Brigham's development into an independent, NIH funded patient-oriented researcher, poised for leadership in investigations at the intersection of air pollution, metabolism, and respiratory health, but will also provide critically novel data regarding the impact of indoor UFP exposure in this vulnerable pediatric population.

室内超细颗粒物暴露与呼吸道疾病、炎症和疾病之间的关系 哮喘儿童的氧化应激。 颗粒物 (PM) 是一种标准污染物，接触颗粒物与急性和慢性健康有关 影响，包括呼吸道疾病发病率和死亡率。 PM 的最小形式，超细 PM (UFP)，进入并 在肺部自由分散，并可转移到血液中。由于 UFP 尺寸较小， 巨大的表面积：颗粒质量比并携带已知会煽动的吸附有毒污染物 炎症和氧化应激反应。它们被认为是最有害的成分之一 PM 对人类健康的影响，但由于研究的局限性，尚未完成流行病学调查 监控能力最近才被克服。此外，这些颗粒的来源通常是独特的， 和室内暴露（即烹饪、取暖、环境烟草烟雾）对个人的影响很大 接触。 Brigham 博士是约翰·霍普金斯大学肺科和重症监护医学助理教授 对这些颗粒对呼吸道疾病的影响产生了浓厚的兴趣。她拥有丰富的研究经验 在成人和儿童哮喘健康和哮喘发病代谢危险因素的流行病学研究中 儿科人群，并在一个结合约翰·霍普金斯大学资源的小组内进行研究 医学院和邻近的彭博公共卫生学院拥有支持室内 UFP 的专业知识 监控。 Brigham 博士的提案旨在明确室内 UFP 暴露对哮喘儿童的影响 在巴尔的摩市，这是一个独特的易感人群，其室内空气负担历来不成比例 污染和哮喘患病率是全国平均水平的两倍多。她建议调查：（目标 1） UFP 暴露对儿童哮喘症状、肺功能和救援吸入器使用的影响，（目标 2） UFP 暴露对气道和氧化应激和炎症的全身标志物的影响，以及（目标 3） 通过已知的其他可改变的代谢因素介导 UFP 暴露对哮喘健康的影响 影响对较大 PM 的反应：肥胖和饮食中 omega-3 脂肪酸的摄入量。 该奖项不仅将为布里格姆博士的发展提供杰出的培训工具 独立的、美国国立卫生研究院资助的以患者为中心的研究人员，准备在十字路口的调查中发挥领导作用 空气污染、新陈代谢和呼吸系统健康的影响，但也将提供有关影响的重要新颖数据 该弱势儿科人群的室内 UFP 暴露情况。

项目成果

Childhood Origins of Adult Lung Disease as Opportunities for Prevention.

• DOI: 10.1016/j.jaip.2020.01.015
• 发表时间: 2020-03
• 期刊: The journal of allergy and clinical immunology. In practice
• 作者: Grant T;Brigham EP;McCormack MC
• 通讯作者: McCormack MC

Patterns and predictors of air purifier adherence in children with asthma living in low-income, urban households.

• DOI: 10.1080/02770903.2021.1893745
• 发表时间: 2022-05
• 期刊: The Journal of asthma : official journal of the Association for the Care of Asthma
• 作者: Kaviany P;Brigham EP;Collaco JM;Rice JL;Woo H;Wood M;Koehl R;Wu TD;Eakin MN;Koehler K;Hansel NN;McCormack MC
• 通讯作者: McCormack MC

Lung Health Disparities in Time.

肺部健康的时间差异。

• DOI: 10.1001/jamainternmed.2021.2572
• 发表时间: 2021
• 期刊: JAMA internal medicine
• 影响因子: 39
• 作者: Brigham,Emily;Raju,Sarath
• 通讯作者: Raju,Sarath