Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain

成人大脑的大规模并行高速 3D 功能光声计算机断层扫描

基本信息

  • 批准号:
    10470400
  • 负责人:
  • 金额:
    $ 131.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-08 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT (30 Lines) The BRAIN initiative (RFA-EB-19-002) has called for the development of entirely new or next-generation noninvasive human brain imaging tools and methods that will lead to transformative advances in our understanding of the human brain. Functional MRI (fMRI) at ultrahigh fields has made tremendous improvements in spatiotemporal resolution, allowing brain function to be studied on the level of cortical layers and columns. However, fMRI is generally considered to have a low sensitivity and strong tissue background for detection of function. Positron emission tomography provides powerful metabolic imaging through radioactive tracers but suffers low spatial resolution, as is diffuse optical tomography despite its advantages in speed, cost, and portability. Ultrasound-only imaging cannot image adult human brains because the ultrasonic waves are attenuated and aberrated twice by the skull due to the round-trip propagation. To address these issues, we propose to develop 3D photoacoustic computed tomography (PACT) for fast and ultrafast large-scale neural activity imaging in human brains. PACT is especially well suited for detecting hemodynamic changes related to neural activities. It offers comparable spatial resolution but can be made much faster than fMRI. It is directly sensitive to both oxy- and deoxy-hemoglobin linearly with a low tissue background. Other potential benefits of PACT over fMRI include open imaging platforms, minimal site requirements, quiet and bedside operation, magnet-free environment, and low system maintenance. In the last two decades, we have developed photoacoustic technology at multiple spatial scales ranging from microscopic (subcellular and cellular) to macroscopic (whole rodent, whole human breast, ex vivo adult human skull, and preliminary single-channel 2D and 64-channel 3D in vivo adult human brain) imaging. We have revealed hemodynamic response in the rodent brain to whisker or electrical stimulation and mapped the resting- state functional connectivity of the rat brain in the deep thalamic region. We have also developed sophisticated numerical methods for simulating photoacoustic wave propagation in heterogeneous media and developed frameworks for image reconstruction in acoustically heterogeneous media. Further, we have successfully demonstrated ex vivo PACT through adult human skulls and acquired preliminary images of human heads in vivo. We propose to translate these advances in PACT to human brain imaging through two specific aims: Aim 1: Develop massively parallel high-speed 3D PACT for in vivo fast and ultrafast functional human brain imaging. Aim 2: Validate functional PACT in adult humans in vivo by comparing with ultrahigh-field 7 T fMRI.
摘要(30行)

项目成果

期刊论文数量(0)
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Danny JJ WANG其他文献

Danny JJ WANG的其他文献

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{{ truncateString('Danny JJ WANG', 18)}}的其他基金

ISMRM workshop on MRI of Neuromodulation
ISMRM 神经调节 MRI 研讨会
  • 批准号:
    10540622
  • 财政年份:
    2022
  • 资助金额:
    $ 131.04万
  • 项目类别:
Laminar Perfusion Imaging
层流灌注成像
  • 批准号:
    10629329
  • 财政年份:
    2021
  • 资助金额:
    $ 131.04万
  • 项目类别:
Laminar Perfusion Imaging
层流灌注成像
  • 批准号:
    10455051
  • 财政年份:
    2021
  • 资助金额:
    $ 131.04万
  • 项目类别:
Laminar Perfusion Imaging
层流灌注成像
  • 批准号:
    10288461
  • 财政年份:
    2021
  • 资助金额:
    $ 131.04万
  • 项目类别:
Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
成人大脑的大规模并行高速 3D 功能光声计算机断层扫描
  • 批准号:
    10685975
  • 财政年份:
    2020
  • 资助金额:
    $ 131.04万
  • 项目类别:
Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
成人大脑的大规模并行高速 3D 功能光声计算机断层扫描
  • 批准号:
    10007184
  • 财政年份:
    2020
  • 资助金额:
    $ 131.04万
  • 项目类别:
BBB Permeability Imaging in CADASIL
CADASIL 中的 BBB 渗透性成像
  • 批准号:
    10548228
  • 财政年份:
    2020
  • 资助金额:
    $ 131.04万
  • 项目类别:
Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
成人大脑的大规模并行高速 3D 功能光声计算机断层扫描
  • 批准号:
    10256763
  • 财政年份:
    2020
  • 资助金额:
    $ 131.04万
  • 项目类别:
BBB Permeability Imaging in CADASIL
CADASIL 中的 BBB 渗透性成像
  • 批准号:
    10335122
  • 财政年份:
    2020
  • 资助金额:
    $ 131.04万
  • 项目类别:
Multiband ASL for Alzheimer's Disease
多频段 ASL 治疗阿尔茨海默病
  • 批准号:
    10120556
  • 财政年份:
    2019
  • 资助金额:
    $ 131.04万
  • 项目类别:

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