Occupational Inhalation Exposure to Infectious Respiratory Virus Aerosols in Medical Facilities

医疗设施中职业吸入暴露于传染性呼吸道病毒气溶胶

基本信息

  • 批准号:
    10472402
  • 负责人:
  • 金额:
    $ 21.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-01 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Accurate assessment of healthcare workers’ personal exposure to airborne pathogenic viruses is hampered by existing bioaerosol samplers, which are either inefficient in sampling infectious airborne viruses and maintaining their viability, or not suitable for personal sampling. The goal of this proposed work is to more accurately assess personal exposure resulting from different transmission modes of airborne infectious viruses. This will be accomplished by empowering the National Institute for Occupational Safety and Health (NIOSH) bioaerosol sampler to be the personal sampler of choice so that it can efficiently collect airborne virus-containing particles by their particle size and maintain their viability information for exposure risk assessment. The two specific aims of this proposal are to: (1) Calibrate the NIOSH sampler against the gold- standard reference of Viable Virus Aerosol Sampler (VIVAS). The VIVAS is highly efficient in collecting viable airborne viruses, but too large and heavy for personal sampling. The calibration will be conducted using lab-generated respiratory virus aerosols to obtain correction factors for determining viable virus aerosol concentrations using the NIOSH sampler. (2) Evaluate personal exposures of healthcare workers to airborne viruses using the calibrated NIOSH sampler. Field tests of co-located NIOSH sampler and the VIVAS at a student health care center (SHCC) will corroborate the lab-generated correction factors in a real-world environment. Sampling will then be conducted using the calibrated NIOSH sampler to assess the personal exposures of the receptionist, healthcare providers, and medical assistants at the SHCC during flu season. Results of the size-fractionated virus-containing particles collected by different stages of the NIOSH sampler will bring to light the relative importance of the different transmission modes of airborne viruses. Paired comparisons of the personal vs. stationary samplings will reveal if stationary sampling can substitute for personal sampling. Knowledge learned from the proposed study will allow setting of administrative polices and engineering control that better protect healthcare workers from undesired exposure to airborne infectious viruses. This proposal responds to two goals set by NIOSH’s Strategic Plans for FY 2019-23 that best represent the health and safety issues facing the U.S. workforce: Goal 3 - reduce occupational infectious disease, and Goal 5 - reduce occupational respiratory disease. Specifically, Goal 3.3 - infectious disease transmission, and Activity Goal 3.3.1 - conduct basic/ etiologic research to better understand influenza aerobiology and transmission in healthcare settings.
项目总结

项目成果

期刊论文数量(0)
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会议论文数量(0)
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JOHN A LEDNICKY其他文献

JOHN A LEDNICKY的其他文献

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{{ truncateString('JOHN A LEDNICKY', 18)}}的其他基金

T AG REACTIVE PROTEINS INDENTIFIED BY TWO HYBRID SYSTEM
两种混合系统鉴定的标签反应蛋白
  • 批准号:
    2102460
  • 财政年份:
    1995
  • 资助金额:
    $ 21.18万
  • 项目类别:
T-AG REACTIVE PROTEINS INDENTIFIED BY TWO HYBRID SYSTEM
两种混合系统鉴定的 T-AG 反应蛋白
  • 批准号:
    2102458
  • 财政年份:
    1994
  • 资助金额:
    $ 21.18万
  • 项目类别:
T AG REACTIVE PROTEINS INDENTIFIED BY TWO HYBRID SYSTEM
两种混合系统鉴定的标签反应蛋白
  • 批准号:
    2102459
  • 财政年份:
    1994
  • 资助金额:
    $ 21.18万
  • 项目类别:

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  • 批准号:
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吸入暴露于雾化的蓝藻毒素会通过激活粒细胞炎症而加重已有的哮喘
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    $ 21.18万
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吸入暴露于雾化的蓝藻毒素会通过激活粒细胞炎症而加重已有的哮喘
  • 批准号:
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  • 财政年份:
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颗粒物和臭氧吸入共同暴露对肺泡上皮再生的影响
  • 批准号:
    10579227
  • 财政年份:
    2020
  • 资助金额:
    $ 21.18万
  • 项目类别:
Impact of particle and ozone inhalation co-exposure on alveolar epithelial regeneration
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  • 批准号:
    10356885
  • 财政年份:
    2020
  • 资助金额:
    $ 21.18万
  • 项目类别:
Impact of particle and ozone inhalation co-exposure on alveolar epithelial regeneration
颗粒物和臭氧吸入共同暴露对肺泡上皮再生的影响
  • 批准号:
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  • 财政年份:
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    19H04282
  • 财政年份:
    2019
  • 资助金额:
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  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
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