Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease

儿科危重心血管和肺病是美国婴儿死亡的主要原因 和其他发达国家。此外，先天性心脏病幸存者的发病率和死亡率也很高。 心脏病手术和其他患有严重心肺疾病的婴儿和儿童，包括这些儿童 有原发性心肌疾病、遗传性结缔组织疾病、肺高压、慢性肺 这些疾病中的许多继发于疾病和脑血管损伤。这些事实表明了一个令人信服的 需要培训针对危重心血管和肺部疾病的儿科内科医生和研究人员。这 续订计划描述了一项多学科培训计划，以准备临床医生-科学家 儿科心脏病学、儿科重症监护或新生儿专科培训计划应严格 在儿科危重心肺疾病实验室或临床研究方面接受过2年的培训 疾病。该计划由实验室、临床和转化研究方面的专家提供支持， 包括心肌和血管生物学、肺和肺血管疾病、遗传学、 蛋白质组学和生物标记物，计算医学，成像，临床试验和临床实施 安全研究。环境为学员提供了许多机会，凭借一流的中心，核心 教师参与的设施和项目，如NHLBI支持的临床试验，阿姆斯特朗研究所 为患者的安全和质量和临床调查研究生培训计划。两个研究区域 建议包括对内科科学家(医学博士或医学博士)的培训。在A.实验室研究中 强调翻译研究的内科科学家。B.支持的临床研究 临床研究研究生培训计划，可能包括临床实施研究， 在重症监护领域至关重要。该计划中的四名实习生将各自有自己的发展 与指导委员会、主要导师和指导人员协商创建的计划计划 一队。该提案纳入了加强招聘人数不足的少数族裔和族裔的战略。 由儿科多样性委员会成员领导的小组，并在 负责任的研究行为。在项目结束时，学员将为过渡做好充分准备 在儿科心脏病学和重症监护领域发展独立资助的学术职位 从事研究工作。

Pediatric critical cardiovascular and lung disorders are the leading causes of infant mortality in the United States and other developed nations. In addition, there is significant morbidity and mortality in survivors of congenital heart disease surgery and other infants and children with critical heart and lung disorders including those children with primary myocardial diseases, inherited disorders of connective tissue, pulmonary hypertension, chronic lung disease and cerebrovascular injury secondary to many of these diseases. These facts indicate a compelling need for training pediatric physician-investigators oriented towards critical cardiovascular and lung disease. This renewal proposal describes a multidisciplinary training program to prepare clinician-scientists who are in subspecialty training programs for Pediatric Cardiology, Pediatric Critical Care or Neonatology to be rigorously trained for 2 years in either laboratory or clinical investigation related to pediatric critical cardiovascular and lung disease. The program is supported by faculty who are experts in laboratory, clinical and translational research, including expertise in myocardial and vascular biology, lung and pulmonary vascular disorders, genetics, proteomics and biomarkers, computational medicine, imaging, clinical trials and clinical implementation and safety research. The environment provides many opportunities for trainees by virtue of superb centers, core facilities and programs in which faculty participate such as NHLBI supported clinical trials, the Armstrong Institute for Patient Safety and Quality and a Graduate Training Program in Clinical Investigation. Two research tracts are proposed including training for physician scientists (M.D. or M.D., Ph.D.) in A. Laboratory research for physician scientists with an emphasis on translational research. B. Clinical investigation supported by the Graduate Training Program in Clinical Investigation, which may include clinical implementation research which is vitally important in critical care fields. Each of four trainees in the program will have an individual development plan program that is created in consultation with a Steering Committee, a primary mentor and mentorship team. The proposal incorporates strategies to enhance recruitment of underrepresented minority and ethnic groups with leadership from a member of the Pediatric Department diversity committee, and training in the responsible conduct of research. At the conclusion of the program, the trainees will be well prepared to transition towards positions in academic pediatric cardiology and intensive care fields developing funded independent research careers.