Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease

儿科危重心肺疾病临床科学家培训

• 批准号: 10678688
• 负责人: Melania Maria Bembea
• 金额: $ 26.63万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678688
• 关键词: Childhood; Pulmonary Heart Disease; Scientist; Training

Pediatric critical cardiovascular and lung disorders are the leading causes of infant mortality in the United States and other developed nations. In addition, there is significant morbidity and mortality in survivors of congenital heart disease surgery and other infants and children with critical heart and lung disorders including those children with primary myocardial diseases, inherited disorders of connective tissue, pulmonary hypertension, chronic lung disease and cerebrovascular injury secondary to many of these diseases. These facts indicate a compelling need for training pediatric physician-investigators oriented towards critical cardiovascular and lung disease. This renewal proposal describes a multidisciplinary training program to prepare clinician-scientists who are in subspecialty training programs for Pediatric Cardiology, Pediatric Critical Care or Neonatology to be rigorously trained for 2 years in either laboratory or clinical investigation related to pediatric critical cardiovascular and lung disease. The program is supported by faculty who are experts in laboratory, clinical and translational research, including expertise in myocardial and vascular biology, lung and pulmonary vascular disorders, genetics, proteomics and biomarkers, computational medicine, imaging, clinical trials and clinical implementation and safety research. The environment provides many opportunities for trainees by virtue of superb centers, core facilities and programs in which faculty participate such as NHLBI supported clinical trials, the Armstrong Institute for Patient Safety and Quality and a Graduate Training Program in Clinical Investigation. Two research tracts are proposed including training for physician scientists (M.D. or M.D., Ph.D.) in A. Laboratory research for physician scientists with an emphasis on translational research. B. Clinical investigation supported by the Graduate Training Program in Clinical Investigation, which may include clinical implementation research which is vitally important in critical care fields. Each of four trainees in the program will have an individual development plan program that is created in consultation with a Steering Committee, a primary mentor and mentorship team. The proposal incorporates strategies to enhance recruitment of underrepresented minority and ethnic groups with leadership from a member of the Pediatric Department diversity committee, and training in the responsible conduct of research. At the conclusion of the program, the trainees will be well prepared to transition towards positions in academic pediatric cardiology and intensive care fields developing funded independent research careers.

儿科危重心血管和肺部疾病是美国婴儿死亡的主要原因 和其他发达国家。此外，在先天性心脏病的幸存者中有显著的发病率和死亡率。 心脏病手术和其他婴儿和患有严重心脏和肺部疾病的儿童，包括 原发性心肌疾病、结缔组织遗传性疾病、肺动脉高压、慢性肺 疾病和脑血管损伤继发于许多这些疾病。这些事实表明， 需要培训儿科医生，研究人员面向严重的心血管和肺部疾病。这 更新提案描述了一个多学科的培训计划，以准备临床科学家谁是在 儿科心脏病学、儿科重症监护或新生儿病学的子专业培训计划将得到严格执行 在儿科危重心血管和肺部相关的实验室或临床研究中接受过2年培训 疾病该计划由实验室，临床和转化研究专家支持， 包括心肌和血管生物学，肺和肺血管疾病，遗传学， 蛋白质组学和生物标志物，计算医学，成像，临床试验和临床实施， 安全研究。环境提供了许多机会，学员凭借一流的中心，核心 教师参与的设施和项目，如NHLBI支持的临床试验，阿姆斯特朗研究所 患者安全和质量以及临床研究的研究生培训计划。两篇研究论文 建议包括培训医生科学家（医学博士，或者医学博士博士）以.实验室研究 医生科学家，重点是转化研究。B。临床研究由 临床研究的研究生培训计划，其中可能包括临床实施研究， 在重症监护领域至关重要。该计划的四名受训人员中的每一个都将有一个单独的发展 与指导委员会、主要导师和导师协商创建的计划程序 团队该提案纳入了加强征聘任职人数不足的少数民族和族裔工作人员的战略， 由儿科部门多样性委员会成员领导的小组，以及 负责任地进行研究。在课程结束时，学员将为过渡做好充分准备 在学术儿科心脏病学和重症监护领域的立场，发展资助的独立 研究生涯。

项目成果

A case of right aortic arch with isolated left innominate artery and global cerebral white matter atrophy.

右主动脉弓伴左无名动脉孤立伴全脑白质萎缩一例。

• DOI: 10.1017/s1047951119001537
• 发表时间: 2019
• 期刊: Cardiology in the young
• 影响因子: 1
• 作者: Binka,Edem;Sun,LisaR;Gailloud,Philippe;Chiu,JoanneS
• 通讯作者: Chiu,JoanneS

Real-World Strategies to Treat Hypertension Associated with Pediatric Obesity.

• DOI: 10.1007/s11906-019-0922-2
• 发表时间: 2019-02-12
• 期刊: Current hypertension reports
• 影响因子: 5.6

Sustained peripheral immune hyper-reactivity (SPIHR): an enduring biomarker of altered inflammatory responses in adult rats after perinatal brain injury.

• DOI: 10.1186/s12974-021-02291-z
• 发表时间: 2021-10-19
• 期刊: Journal of neuroinflammation
• 影响因子: 9.3
• 作者: Kitase Y;Chin EM;Ramachandra S;Burkhardt C;Madurai NK;Lenz C;Hoon AH Jr;Robinson S;Jantzie LL
• 通讯作者: Jantzie LL

Methadone alters the peripheral inflammatory and central immune landscape following prenatal exposure in rats.

美沙酮改变大鼠产前暴露后的外周炎症和中枢免疫景观。

• DOI: 10.3389/adar.2022.10792
• 发表时间: 2022
• 期刊: Advances in drug and alcohol research
• 作者: Madurai,NethraK;Kitase,Yuma;Hamimi,Sarah;Kirk,ShannonE;Sevensky,Riley;Ramachandra,Sindhu;Muthukumar,Sankar;Vasan,Vikram;Ozen,Maide;Gerner,Gwendolyn;Robinson,Shenandoah;Jantzie,LaurenL
• 通讯作者: Jantzie,LaurenL

Appropriate Use Criteria for paediatric echocardiography in an outpatient practice: a validation study.

门诊儿科超声心动图的适当使用标准：验证研究。

• DOI: 10.1017/s1047951118000513
• 发表时间: 2018
• 期刊: Cardiology in the young
• 影响因子: 1
• 作者: Cartoski,MarkJ;Kiley,Meghan;Spevak,PhilipJ
• 通讯作者: Spevak,PhilipJ