Ambulatory monitoring of a vocal efficiency index to improve the clinical management of voice disorders

动态监测发声效率指数以改善发声障碍的临床管理

• 批准号: 10474472
• 负责人: Daryush Dinyar Mehta
• 金额: $ 35.7万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10474472
• 关键词: Accelerometer; Acoustics; Activities of Daily Living; Adult; Affect; Aftercare; Age; Air Movements; Ambulatory Monitoring; Behavior; Benchmarking; Cellular Phone; Characteristics; Clinic; Clinical; Clinical Management; Clinical Treatment; Data; Diagnosis; Dysphonia; Ecological momentary assessment; Enrollment; Environment; Esthesia; Fatigue; Goals; Health; Health Care Costs; Home; Hour; Individual; Label; Laboratories; Lesion; Measures; Monitor; Muscle Tension; Neck; Nodule; Occupational; Output; Paralysed; Participant; Patients; Performance; Periodicity; Polyps; Population; Prevention; Probability; Production; Productivity; Psychometrics; Reading; Reporting; Series; Standardization; Surface; Techniques; Technology; Time; Translations; United States; Visual; Voice; Voice Disorders; Work; analog; base; clinical predictors; clinically significant; cohort; disability; flexibility; improved; indexing; innovation; microphone; pressure; sensor; sex; social; sound; statistics; surgery outcome; vibration; vocal cord; wearable sensor technology; wireless

Project Summary/Abstract In the United States, voice disorders affect approximately 30% of the adult population at some point in their lives, with about 25 million individuals suffering at any given point in time. The impact of living with a voice disorder is far-reaching, and the societal burden reaches up to $13.5 billion dollars each year due to work-related disability, lost productivity, and direct healthcare costs. Individuals with voice disorders often suffer from heightened sensations of vocal effort and fatigue while speaking that are typically attributed to inefficient vocal function and behavior. Increasing vocal efficiency and decreasing vocal effort and associated vocal fatigue are often goals of clinical treatment paradigms. Thus, vocal efficiency is a highly desirable objective measure for the clinical management of voice disorders, particularly if it can be obtained via ambulatory monitoring to track vocal health and vocal behavior in a patient’s natural environment. The proposed project seeks to develop an index of ambulatory vocal efficiency that integrates estimates of subglottal pressure and vocal sound pressure level to monitor the vocal effort of patients being treated for phonotraumatic vocal cord lesions, non-phonotraumatic vocal hyperfunction, and unilateral vocal fold paralysis. Individuals with healthy vocal status will also be monitored as control subjects matched for sex, age, and occupational/vocal demands. An innovative wearable sensor technology using flexible circuits obtains synchronized data from a wireless neck-surface accelerometer and microphone to track the index of ambulatory vocal efficiency in real-world settings. Integrating the technology into a smartphone platform enables periodic prompting to prompt subjects to rate their level of vocal effort on a visual analog scale. The proposed work pursues critical goals of (a) investigating the clinical validity of the ambulatory vocal efficiency index in patients with voice disorders and vocally healthy matched controls and (b) assessing the ambulatory vocal efficiency index as an objective correlate of self-ratings of vocal effort. The impact of this work is significant because, for the first time, voice clinicians will be able to monitor vocal efficiency in naturalistic, real-world settings to improve the prevention, diagnosis, and treatment of voice disorders.

项目概要/摘要 在美国，大约 30% 的成年人在一生中的某个阶段受到嗓音障碍的影响， 在任何特定时间点都有大约 2500 万人遭受苦难。患有嗓音障碍的影响是 影响深远，由于与工作有关的残疾，每年造成的社会负担高达 135 亿美元， 生产力损失和直接医疗费用。患有嗓音障碍的人常常会出现声音加重的情况 说话时感觉发声费力和疲劳，通常归因于发声功能低下 行为。提高发声效率、减少发声努力和相关的发声疲劳通常是以下目标： 临床治疗范例。因此，声音效率是临床临床非常理想的客观衡量标准。 声音障碍的管理，特别是如果可以通过动态监测来跟踪声音健康状况 以及患者自然环境中的声音行为。 拟议的项目旨在开发一个动态发声效率指数，该指数综合了以下各项的估计： 声门下压力和声压级，用于监测接受治疗的患者的发声力度 声音创伤性声带病变、非声音创伤性声带功能亢进和单侧声带麻痹。 具有健康声音状态的个体也将作为与性别、年龄和年龄相匹配的对照对象进行监测。 职业/声音要求。使用柔性电路的创新可穿戴传感器技术获得 来自无线颈面加速度计和麦克风的同步数据，用于跟踪动态指数 现实环境中的声音效率。将该技术集成到智能手机平台中可以定期 提示 提示受试者在视觉模拟量表上评价他们的发声努力水平。拟议的工作 追求的关键目标是 (a) 研究患者动态发声效率指数的临床有效性 具有声音障碍和声音健康的匹配对照，并且 (b) 评估动态发声效率 指数作为声音努力自我评级的客观相关性。这项工作的影响是重大的，因为对于 声音临床医生将首次能够在自然、真实的环境中监测声音效率，以提高声音效率。 声音障碍的预防、诊断和治疗。