Investigating the relationship between menthol flavor and nicotine metabolism in African Americans who smoke cigarettes
研究吸烟的非裔美国人的薄荷醇风味与尼古丁代谢之间的关系
基本信息
- 批准号:10475019
- 负责人:
- 金额:$ 18.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2023-03-15
- 项目状态:已结题
- 来源:
- 关键词:4-(methylnitrosamino)-1-(3-pyridyl)-1-butanolAddressAdolescentAdultAfricanAfrican AmericanAfrican American populationAreaBehaviorBehavioralBiological MarkersBlood PressureBupropionCardiovascular PhysiologyCessation of lifeCharacteristicsCigaretteCotinineDataDiseaseDrug KineticsElectronic cigaretteExplosionFDA approvedFellowshipGoalsHarm ReductionHealthHeart RateHomeIndividualLungManufacturer NameMeasuresMentholMetabolismNicotineNicotine DependenceNicotine WithdrawalObservational StudyOutcomeParticipantPatient Self-ReportPharmacodynamicsPhasePilot ProjectsPlasmaProxyPublic HealthPulse OximetryReportingResearchRewardsRoleScientistSmokeSmokerSmokingSmoking BehaviorSodium ChlorideSpirometryStatistical Data InterpretationTaste PerceptionTobaccoTobacco useToxic effectToxicant exposureTrainingUnited StatesVulnerable PopulationsYouthbasecigarette cravingcigarette smokecombustible tobaccoelectronic cigarette useelectronic cigarette userelectronic liquidexperimental studyhealth disparityinterestknowledge baselung injurymouse modelnicotine gumnicotine patchnicotine replacementnicotine usepredicting responseprimary outcomepulmonary functionracial differenceresponseskillssmoking cessationsmoking-related diseasetobacco productstobacco regulationtoxicantvareniclinevolatile organic compoundyoung adult
项目摘要
Project Summary
African Americans are more likely than Whites to die from smoking related diseases and are less successful at
smoking cessation with the current FDA-approved aids. Thus, this proposal seeks to investigate the use of e-
cigarettes on smoking reduction in African American and White smokers. This proposal will elucidate the
relationship between nicotine metabolism and nicotine concentrations in e-cigarettes on smoking behavior and
toxicant exposure in African American and White smokers. We hypothesize that slow nicotine metabolizers will
have higher nicotine plasma levels than normal nicotine metabolizers at all nicotine concentrations and report
greater positive subjective effects. Additionally, we hypothesize that slow nicotine metabolizers will be more
likely to reduce their smoking with e-cigarettes because studies show slower nicotine metabolizing smokers
are more successful on nicotine replacement therapies than normal or fast nicotine metabolizing smokers. The
outcomes of the project will provide new information to further develop the knowledge base in understanding
which nicotine concentration manufacturers should include in e-liquids to reduce smoking behaviors.
Regulatory efforts could cap the nicotine content in e-liquids to reduce the addictive potential of e-cigs to
adolescents but provide a harm reduction avenue for smokers, especially African American smokers, to protect
overall public health.
项目总结
项目成果
期刊论文数量(0)
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会议论文数量(0)
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{{ truncateString('Asti B Jackson', 18)}}的其他基金
Investigating the relationship between menthol flavor and nicotine metabolism in African Americans who smoke cigarettes
研究吸烟的非裔美国人的薄荷醇风味与尼古丁代谢之间的关系
- 批准号:
10054376 - 财政年份:2020
- 资助金额:
$ 18.87万 - 项目类别:
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