Investigating the relationship between menthol flavor and nicotine metabolism in African Americans who smoke cigarettes

研究吸烟的非裔美国人的薄荷醇风味与尼古丁代谢之间的关系

• 批准号: 10054376
• 负责人: Asti B Jackson
• 金额: $ 18.87万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10054376
• 关键词: Address; Adolescent; Adult; African; African American; Area; Behavior; Behavioral; Biological Markers; Blood Pressure; Bupropion; Cardiovascular Physiology; Cessation of life; Characteristics; Cigarette; Cotinine; Data; Disease; Drug Kinetics; Electronic cigarette; Explosion; FDA approved; Fellowship; Goals; Harm Reduction; Health; Heart Rate; Home environment; Individual; Lung; Manufacturer Name; Measures; Menthol; Metabolism; Nicotine; Nicotine Dependence; Nicotine Withdrawal; Observational Study; Outcome; Participant; Patient Self-Report; Pharmacodynamics; Phase; Pilot Projects; Plasma; Proxy; Public Health; Pulse Oximetry; Regulation; Reporting; Research; Respiratory physiology; Rewards; Role; Scientist; Smoke; Smoker; Smoking; Smoking Behavior; Sodium Chloride; Spirometry; Statistical Data Interpretation; Taste Perception; Tobacco; Toxic effect; Toxicant exposure; Training; United States; Vulnerable Populations; Youth; base; craving; electronic cigarette use; electronic cigarette user; electronic liquid; experimental study; health disparity; interest; knowledge base; lung injury; mouse model; nicotine gum; nicotine patch; nicotine replacement; nicotine use; predicting response; primary outcome; racial difference; response; skills; smoking cessation; tobacco products; toxicant; varenicline; volatile organic compound; young adult

Project Summary African Americans are more likely than Whites to die from smoking related diseases and are less successful at smoking cessation with the current FDA-approved aids. Thus, this proposal seeks to investigate the use of e- cigarettes on smoking reduction in African American and White smokers. This proposal will elucidate the relationship between nicotine metabolism and nicotine concentrations in e-cigarettes on smoking behavior and toxicant exposure in African American and White smokers. We hypothesize that slow nicotine metabolizers will have higher nicotine plasma levels than normal nicotine metabolizers at all nicotine concentrations and report greater positive subjective effects. Additionally, we hypothesize that slow nicotine metabolizers will be more likely to reduce their smoking with e-cigarettes because studies show slower nicotine metabolizing smokers are more successful on nicotine replacement therapies than normal or fast nicotine metabolizing smokers. The outcomes of the project will provide new information to further develop the knowledge base in understanding which nicotine concentration manufacturers should include in e-liquids to reduce smoking behaviors. Regulatory efforts could cap the nicotine content in e-liquids to reduce the addictive potential of e-cigs to adolescents but provide a harm reduction avenue for smokers, especially African American smokers, to protect overall public health.

项目摘要 非裔美国人比白人更有可能死于与吸烟有关的疾病， 戒烟与目前FDA批准的艾滋病。因此，本建议旨在研究电子商务的使用， 香烟对非裔美国人和白色吸烟者吸烟减少的影响。本提案将阐明 尼古丁代谢与电子烟中尼古丁浓度对吸烟行为的关系， 非裔美国人和白色吸烟者的毒物暴露。我们假设尼古丁代谢缓慢的人 在所有尼古丁浓度下，尼古丁血浆水平均高于正常尼古丁代谢者， 积极的主观效果。此外，我们假设尼古丁代谢缓慢的人 他们可能会减少使用电子烟，因为研究表明吸烟者尼古丁代谢较慢 尼古丁替代疗法比正常或尼古丁代谢快的吸烟者更成功。的 该项目的成果将提供新的信息，以进一步发展知识库， 制造商应在电子烟液中加入哪些尼古丁浓度以减少吸烟行为。 监管工作可以限制电子烟液中的尼古丁含量，以减少电子烟的成瘾潜力， 青少年，但为吸烟者，特别是非裔美国人吸烟者提供了减少危害的途径，以保护 整体公共卫生。