TRANSFORM: Translational Research that Adapts New Science FOR Maltreatment prevention

转变：采用新科学预防虐待的转化研究

• 批准号: 10475233
• 负责人: DANTE CICCHETTI CICCHETTI
• 金额: $ 156.59万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-13 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475233
• 关键词: Address; Adolescent; Adult; Applied Research; Basic Science; Child; Child Abuse and Neglect; Child Mental Health; Child Welfare; Childhood; Communities; Consensus; Development; Discipline; Domestic abuse; Environment; Evidence based intervention; Evidence based program; Evidence based treatment; Experimental Designs; Exposure to; Family; Formulation; Fostering; Foundations; Genetic; Goals; Government; Human; Individual; Infrastructure; Injury; Institutes; Interdisciplinary Study; International; Intervention; Investigation; Laboratories; Lawyers; Leadership; Legal; Life; Maps; Measures; Mediator of activation protein; Mental Health; Methodology; Methods; Minnesota; Modeling; Mothers; National Institute of Child Health and Human Development; Neurosciences; Outcome; Postdoctoral Fellow; Postpartum Period; Prevention; Prevention Research; Principal Investigator; Provider; Psychopathology; Quality Control; Randomized Controlled Trials; Reporting; Research; Research Methodology; Research Personnel; Research Project Grants; Resource Sharing; Resources; Science; Scientist; Sexual abuse; Societies; Solid; System; Testing; Training; Training and Education; Translating; Translational Research; Trauma; Underrepresented Minority; Universities; Work; abuse neglect; analytical method; career; career development; clinical practice; community engagement; community violence; court; emotional abuse; evidence base; experience; graduate student; high risk; high risk population; innovation; maltreatment; multidisciplinary; next generation; outreach; physical abuse; physical conditioning; preference; prenatal; prevent; preventive intervention; programs; prospective; research data dissemination; service providers; therapy design; translational approach

ABSTRACT - OVERALL CORE Each year millions of young children and adolescents in the U.S. are reported to Child Protective agencies for maltreatment (neglect, physical, sexual, or emotional abuse), and experience additional forms of trauma such as exposure to domestic abuse, community violence, life-threatening illness or injury, or sudden loss. A diverse multidisciplinary team of investigators from the Universities of Rochester and Minnesota will partner with the NICHD to create the TRANSFORM Center (Translational Research that Adapts New Science FOR Maltreatment Prevention) to prevent child maltreatment and to address its sequelae. The unique combined capacity of this multi-investigator Center, i.e., the expertise, infrastructure support, human/fiscal resources, and research/intervention strategies would not be feasible for a single investigator working alone in one laboratory. Building on current state-of-the-science research methodologies and clinical practices that address the personal and societal burden associated with child abuse and neglect, TRANSFORM will leverage theoretically-grounded evidence-based research and preventive interventions to optimize outcomes in children. In doing so, the Center will apply the most advanced concepts and methods derived from child maltreatment research, and leverage numerous longstanding relationships within the child welfare community to make its impact. TRANSFORM will use a multidisciplinary translational approach embedded in a developmental psychopathology framework that builds upon discoveries in genetics, neuroscience, prevention and intervention science, child welfare, and court systems to develop an innovative national resource for diverse disciplines and professional arenas. To achieve its objectives, TRANSFORM will utilize two Research Projects and two mutually-informative and integrated Cores: a Community Engagement Core, and an Administrative Core. This `team science' model brings together professionals with different backgrounds including basic and applied scientists who provide the theoretical grounding for project hypotheses, program developers who are the architects of evidence-based programs, research methodologists who advise on the appropriate experimental designs for testing the models, including the constructs and measures that will map onto the mediators and moderators, the analytical methods for evaluating results, attorneys who can translate results into legal and judicial systems, and child-serving professionals and governmental stakeholders who will participate in dissemination activities. TRANSFORM will be led by Drs. Sheree Toth and Dante Cicchetti, internationally-recognized leaders in the field of child maltreatment, whose collaborative work spans almost four decades and provides a solid foundation for conducting groundbreaking longitudinal and prevention research that will contribute to widespread engagement across multiple child-serving systems.

摘要-整体核心 每年，美国有数以百万计的幼儿和青少年向儿童保护机构举报 虐待（忽视、身体、性或情感虐待），并经历其他形式的创伤，例如 遭受家庭暴力、社区暴力、危及生命的疾病或伤害，或突然失去亲人。多元化的 来自罗切斯特大学和明尼苏达大学的多学科研究小组将与 NICHD 将创建 TRANSFORM 中心（适应新科学的转化研究 虐待预防）以防止虐待儿童并解决其后遗症。独特的组合 这个多研究者中心的能力，即专业知识、基础设施支持、人力/财政资源和 对于在一个实验室单独工作的单个研究者来说，研究/干预策略是不可行的。 以当前最先进的科学研究方法和临床实践为基础，解决 TRANSFORM 将利用与虐待和忽视儿童相关的个人和社会负担 以理论为基础的循证研究和预防干预措施，以优化儿童的结局。 在此过程中，该中心将应用源自虐待儿童的最先进概念和方法 研究，并利用儿童福利界的众多长期关系来使其 影响。 TRANSFORM 将使用嵌入发展的多学科转化方法 精神病理学框架建立在遗传学、神经科学、预防和 干预科学、儿童福利和法院系统，为不同群体开发创新的国家资源 学科和专业领域。为了实现其目标，TRANSFORM 将利用两个研究项目 以及两个相互信息和综合的核心：社区参与核心和行政管理核心 核。这种“团队科学”模式汇集了具有不同背景的专业人士，包括基础和 为项目假设提供理论基础的应用科学家、为项目假设提供理论基础的程序开发人员 循证计划的架构师、研究方法学家，他们就适当的建议提供建议 用于测试模型的实验设计，包括将映射到模型上的构造和测量 调解员和主持人、评估结果的分析方法、可以翻译结果的律师 法律和司法系统以及儿童服务专业人员和政府利益相关者，他们将 参与传播活动。 TRANSFORM 将由博士领导。雪莉·托特和但丁·西凯蒂， 虐待儿童领域国际公认的领导者，他们的合作工作几乎涵盖 四个十年，为开展开创性的纵向和预防工作提供了坚实的基础 研究将有助于跨多个儿童服务系统的广泛参与。