Hopkins Center to Promote resilience in persons and families living with multiple chronic conditions (the PROMOTE Center)

试点行政核心摘要 PROMOTE中心的试点管理核心将支持从以提供商为中心， 疾病特异性生物医学方法，以人为本，以社区为中心的方法，以解决多种 慢性病该中心的研究人员将开发和评估创新的，理论驱动的干预 使用以人为本的生物行为方法和措施来产生新知识的战略， 为政策和实践提供信息。严格的，多方法的干预措施的发展，测试， 传播将涉及跨学科科学家与目标人群和其他关键群体的伙伴关系。 利益相关者了解和解决多重，相互关联的因素（环境和个人）的关键， 个人和家庭复原力。通过以下途径获得的无与伦比的跨学科资源和专业知识： 约翰霍普金斯临床和翻译研究所; JHSON科学和创新办公室 和生物统计学和方法核心;我们机构的许多中心和研究所;以及外部 核心将动员合作，推动在恢复力和多种慢性疾病方面的科学进步。 条件以及建立新的研究团队来推动它。试点行政核心的具体目标是 至：1.支持制定和实施严格的、社区知情的研究设计和方法， 推进多种慢性病的跨学科科学的试点项目。1.1建立多个定期 论坛，以促进构思，创新和跨学科交流，以推进多种慢性病的科学 条件1.2提供P30中试项目咨询、前期数据分析、设计咨询 1.3提供重点突出的方法和分析支持，并为正在进行的 通过P30项目与经验丰富的方法学家、统计学家和所有试点项目的粉笔谈话， 董事们。2.为使用共同数据要素、数据管理和在试点项目之间共享提供技术支持 2.1为P30项目提供支持，以有意义地整合共同措施 并为通用度量数据仓库提供基础架构，以便在 2.2促进研究设计和对试点项目汇总数据的分析， 其他P20/P30站点，以回答P30中心使命不可或缺的研究问题。2.3促进数据 管理小组，以确保所有项目的数据完整性。促进发展和可持续性 多产的跨学科研究团队，以推进多种慢性疾病的科学，包括促进 跨中心的科学交流，以推进弹性和慢性疾病的证据4。管理试点项目 程序.这将包括组织年度征集试点干预研究提案，组织和管理 试点前供资。将实施程序，以评估试点建议的进展、科学价值和 在试点项目成功执行后，有可能导致可供资助的研究计划。

Pilot Administrative Core Abstract The Pilot Administrative Core of the PROMOTE center will support a paradigm shift from provider-centric, disease-specific biomedical approaches to person-centered, community focused methods to address multiple chronic conditions. The Center investigators will develop and evaluate innovative, theory-driven intervention strategies using person-centered bio behavioral approaches and measures to generate new knowledge that informs policy and practice. Rigorous, multi-method approaches to intervention development, testing, and dissemination will involve interdisciplinary scientists partnering with target populations and other key stakeholders to understand and address multiple, inter-related factors (environmental and individual) critical to individual and family resilience. Unparalleled interdisciplinary resources and expertise available through the Johns Hopkins Institute for Clinical and Translation Research; the JHSON Office for Science and Innovation and Biostatistics and Methods Core; numerous Centers and Institutes across our institution; as well as external collaborations will be mobilized by the Core to drive scientific advances in resilience and multiple chronic conditions as well as to build new research teams to drive it. The specific aims of the Pilot Administrative Core are to: 1. Support the development and implementation of rigorous, community-informed research designs and methods for pilot projects that advance interdisciplinary science of multiple chronic conditions. 1.1 Establish multiple, regular forums to promote ideation, innovation, and interdisciplinary exchange to advance the science of multiple chronic conditions. 1.2 Provide consultation, preliminary data analysis, and design consultation of P30 pilot project proposals and grants.1.3 Provide focused methods and analysis support and cross learning for on-going projects through chalk-talks by P30 projects with experienced methodologists, statisticians, and all pilot project directors. 2. Provide technical support for use of common data elements, data management and sharing across pilot projects and NINR Centers 2.1 Provide support for P30 projects to meaningfully integrate common measures into their projects and provide the infrastructure for a common measures data warehouse to merge data across all of the P30 projects.2.2 Facilitate research design and analysis of the pooled data across pilot projects and other P20/P30 sites to answer research questions integral to the P30 Center's mission. 2.3 Facilitate a data management group to ensure data integrity across all projects.3. Facilitate the development and sustainability of productive interdisciplinary research teams to advance the science of multiple chronic conditions including facilitating cross center scientific exchange to advance evidence on resilience and chronic conditions 4. Administer the pilot project program. This will include organizing annual calls for proposals of pilot intervention studies, organizing and administering pre-pilot funding. Procedures will be implemented to evaluate the pilot proposals on their progress, scientific merit and potential to lead to fundable research programs after the successful execution of the pilot projects.