Hopkins Center to Promote resilience in persons and families living with multiple chronic conditions (the PROMOTE Center)

霍普金斯促进患有多种慢性病的个人和家庭的复原力中心（PROMOTE 中心）

• 批准号: 10475038
• 负责人: Cheryl Dennison Himmelfarb
• 金额: $ 15.01万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-22 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475038
• 关键词: Address; Adult; Behavioral; Biostatistical Methods; Cells; Chalk; Chronic; Clinical; Clinical Research; Collaborations; Common Data Element; Communities; Consultations; Data; Data Analyses; Data Pooling; Development; Disease; Educational workshop; Ensure; Environment; Faculty; Family; Funding; Funding Agency; Grant; Health; Individual; Infrastructure; Institutes; Institution; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Lead; Learning; Link; Measurement; Measures; Methodology; Methods; Mission; Modeling; Participant; Persons; Physiological Processes; Pilot Projects; Policies; Procedures; Productivity; Provider; Research; Research Design; Research Methodology; Research Personnel; Research Support; Resources; Science; Scientific Advances and Accomplishments; Scientist; Site; Societies; Target Populations; Testing; Training; Translational Research; Writing; biobehavior; community based participatory research; community engagement; cytokine; data integrity; data management; data sharing; data warehouse; design; experience; ideation; improved; innovation; meetings; method development; multiple chronic conditions; novel; person centered; programs; ranpirnase; resilience; theories; therapy development

Pilot Administrative Core Abstract The Pilot Administrative Core of the PROMOTE center will support a paradigm shift from provider-centric, disease-specific biomedical approaches to person-centered, community focused methods to address multiple chronic conditions. The Center investigators will develop and evaluate innovative, theory-driven intervention strategies using person-centered bio behavioral approaches and measures to generate new knowledge that informs policy and practice. Rigorous, multi-method approaches to intervention development, testing, and dissemination will involve interdisciplinary scientists partnering with target populations and other key stakeholders to understand and address multiple, inter-related factors (environmental and individual) critical to individual and family resilience. Unparalleled interdisciplinary resources and expertise available through the Johns Hopkins Institute for Clinical and Translation Research; the JHSON Office for Science and Innovation and Biostatistics and Methods Core; numerous Centers and Institutes across our institution; as well as external collaborations will be mobilized by the Core to drive scientific advances in resilience and multiple chronic conditions as well as to build new research teams to drive it. The specific aims of the Pilot Administrative Core are to: 1. Support the development and implementation of rigorous, community-informed research designs and methods for pilot projects that advance interdisciplinary science of multiple chronic conditions. 1.1 Establish multiple, regular forums to promote ideation, innovation, and interdisciplinary exchange to advance the science of multiple chronic conditions. 1.2 Provide consultation, preliminary data analysis, and design consultation of P30 pilot project proposals and grants.1.3 Provide focused methods and analysis support and cross learning for on-going projects through chalk-talks by P30 projects with experienced methodologists, statisticians, and all pilot project directors. 2. Provide technical support for use of common data elements, data management and sharing across pilot projects and NINR Centers 2.1 Provide support for P30 projects to meaningfully integrate common measures into their projects and provide the infrastructure for a common measures data warehouse to merge data across all of the P30 projects.2.2 Facilitate research design and analysis of the pooled data across pilot projects and other P20/P30 sites to answer research questions integral to the P30 Center's mission. 2.3 Facilitate a data management group to ensure data integrity across all projects.3. Facilitate the development and sustainability of productive interdisciplinary research teams to advance the science of multiple chronic conditions including facilitating cross center scientific exchange to advance evidence on resilience and chronic conditions 4. Administer the pilot project program. This will include organizing annual calls for proposals of pilot intervention studies, organizing and administering pre-pilot funding. Procedures will be implemented to evaluate the pilot proposals on their progress, scientific merit and potential to lead to fundable research programs after the successful execution of the pilot projects.

试点行政核心摘要 推广中心的试点管理核心将支持从以提供商为中心的范式转变， 针对疾病的生物医学方法，以个人为中心，以社区为重点，解决多种 慢性疾病。中心调查人员将开发和评估创新的、理论驱动的干预措施 使用以人为中心的生物行为方法和措施来产生新知识的策略 为政策和实践提供信息。采用严格的多方法方法进行干预开发、测试和 传播将涉及跨学科的科学家与目标人群和其他关键 利益相关者了解和解决多种相互关联的关键因素(环境和个人) 个人和家庭的韧性。无与伦比的跨学科资源和专业知识可通过 约翰霍普金斯临床与翻译研究所；JHSON科学与创新办公室 和生物统计学和方法核心；我们机构以及外部的许多中心和研究所； 核心将动员合作，以推动恢复力和多种慢性疾病方面的科学进步 并建立新的研究团队来推动这一进程。试点行政核心的具体目标是 为：1.支持制定和实施严格的、社区知情的研究设计和方法 推进多种慢性病跨学科科学的试点项目。1.1建立多个常规的 促进思维、创新和跨学科交流的论坛，以推进多发性慢性病的科学 条件。1.2提供P30试点项目咨询、初步数据分析、设计咨询 建议书和赠款。1.3为正在进行的工作提供有重点的方法和分析支持以及交叉学习 通过粉笔完成的项目-P30项目与经验丰富的方法学家、统计学家和所有试点项目的会谈 董事们。2.为通用数据元素的使用、数据管理和跨试点共享提供技术支持 项目和NINR中心2.1为P30项目提供支持，以便有意义地整合共同措施 整合到他们的项目中，并为通用度量数据仓库提供基础架构，以便跨 所有P30项目。2.2促进跨试点项目的汇集数据的研究设计和分析 其他P20/P30网站回答P30中心使命不可或缺的研究问题。2.3促进数据 管理小组确保所有项目的数据完整性。促进发展和可持续发展 富有成效的跨学科研究团队，推动多种慢性病的科学研究，包括促进 跨中心科学交流，以促进关于复原力和慢性病的证据4.管理试点项目 程序。这将包括组织年度征求试点干预研究的建议，组织和管理 试点前期资金。将实施程序，以评估试点提案的进展情况、科学价值和 在试点项目成功实施后，有可能导致可资助的研究计划。