Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)

宾州肌肉骨骼疾病中心（PCMD）将继续提供关键资源， 计划，并提高研究人员的研究生产力，以解决多学科研究 肌肉骨骼问题的策略。该中心的总体目标是促进合作互动 在研究者中，加速和丰富正在进行的研究的有效性和效率，培养新的 合作和新的研究，并最终将我们的研究成果转化为更好的新疗法， 肌肉骨骼疾病该中心的主题是“肌肉骨骼发育，疾病，损伤和修复” 同时解决三个研究重点领域。我们的PCMD是整个肌肉骨骼研究的家园 宾夕法尼亚大学校园和整个地区和邻国的肌肉骨骼社区的枢纽。 我们中心的一个重点是跨越肌肉骨骼组织的主题，方法和范例 这在研究单个组织时可能被忽略。由于用于评估 一种组织可以帮助其他领域的研究人员，我们的中心将促进这种关键的串扰。为了进一步聚焦， 我们将强调小动物模型利用独特和复杂的方法，跨长度尺度。 PCMD将提供独特的专业知识和工具，以调查跨这些规模的肌肉骨骼组织。 因此，该中心的主要总体目标仍然是提高和推进研究生产力， 研究人员在肌肉骨骼发育，疾病，损伤和修复提供：目标1：创新， 跨学科、跨长度、跨层次领域的关键资源核心设施。这些核心 设施仍然是µCT成像，生物力学和组织学;目标2：试点和可行性资助计划， 直接指导;目标3：教育和研究充实计划，通过这些计划，成员可以 向各国领导人学习，相互学习。高质量的肌肉骨骼研究正在进行， 宾夕法尼亚州的许多团体，在该地区，以及邻近的州。虽然许多人带来了复杂的方法， 肌肉骨骼问题，很少有所需的专业知识和设施，以执行广泛的严格 和专门的化验。该中心将提供整合技术的机会， 组织功能、损伤、发育、退化、修复和再生的机制， 目标是推进肌肉骨骼系统疾病和损伤的诊断、治疗和预防。 我们中心还有一个无形的特点。虽然我们的肌肉骨骼项目在全国范围内都很强大， 宾大的生物医学研究团体是庞大而多样的。因此，该中心作为一个重要的 机制，以突出我们的成功和肌肉骨骼研究在校园的重要性，以及 在机构领导方面。为我们地区的肌肉骨骼研究人员发出强有力的声音， 支持我们的集体和个人研究目标。通过这些方式，该中心-在联合国的基本支持下， P30 -已经成为并仍然是我们社区不可或缺的资源和倡导者。

The Penn Center for Musculoskeletal Disorders (PCMD) will continue to provide critical resources and programs to, and enhance research productivity of, investigators to address multidisciplinary research strategies for musculoskeletal problems. The overall goal of this Center is to promote cooperative interactions among investigators, accelerate and enrich the effectiveness and efficiency of ongoing research, foster new collaborations and new research, and ultimately, translate our research efforts into better and new therapies for musculoskeletal disorders. The Center theme is “Musculoskeletal Development, Disease, Injury and Repair” while addressing 3 Research Thrust areas. Our PCMD is the home for musculoskeletal research across the Penn campus and a hub for the musculoskeletal community across the region and neighboring states . One focus of our Center is to bridge themes, approaches, and paradigms across musculoskeletal tissues which may be overlooked when studying a single tissue. Since approaches used to evaluate mechanisms in one tissue could aid researchers in other areas, our Center will foster this critical cross-talk. To further focus, we will emphasize small animal models utilizing unique and sophisticated methods that cross length scales. The PCMD will provide unique expertise and tools to investigate musculoskeletal tissues across such scales. Thus, the primary overall Aims of this Center remain to enhance and advance the research productivity of investigators in musculoskeletal development, disease, injury and repair by providing: Aim 1: Innovation within critical resource core facilities in areas that cross disciplines, length scales, and hierarchies. These core facilities remain µCT Imaging, Biomechanics, and Histology; Aim 2: A pilot and feasibility grant program, with direct mentorship; and Aim 3: Educational and research enrichment programs, through which members can learn from national leaders and from each other. High quality musculoskeletal research is being conducted by many groups at Penn, in the region, and neighboring states. While many bring sophisticated approaches to musculoskeletal problems, few have the required expertise and facilities to perform the broad range of rigorous and specialized assays in their own labs. The Center will provide opportunities to integrate techniques to define mechanisms for tissue function, injury, development, degeneration, repair, and regeneration, with the ultimate goal of advancing diagnosis, treatment, and prevention of diseases and injuries of the musculoskeletal system. There is also an intangible feature of our Center. Although our musculoskeletal program is strong nationally, the Penn biomedical research community is large and diverse. As such, the Center serves as an essential mechanism to highlight our successes and the importance of musculoskeletal research across campus, as well as to institutional leadership. Having a strong voice for musculoskeletal researchers for our region is critical to support our collective and individual research goals. In these ways, the Center - with essential support from the P30 - has become and remains an indispensable resource and advocate for our community.