Administrative Core

行政核心

• 批准号: 10403253
• 负责人: LOUIS J SOSLOWSKY
• 金额: $ 24.18万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10403253
• 关键词: Address; Advisory Committees; Animal Model; Animals; Area; Back; Beds; Biological Assay; Cell Nucleus; Cells; Center for Translational Science Activities; Clinical; Committee Membership; Communication; Communities; Data; Development; Ensure; Etiology; Evaluation; Fostering; Frequencies; Funding; Future; Grant; Leadership; Modality; Modeling; Monitor; Musculoskeletal Diseases; Pain; Pathogenesis; Pennsylvania; Physiological Processes; Positioning Attribute; Prevalence; Productivity; Reporting; Research; Research Activity; Research Project Grants; Resources; Role; Scientist; Series; Societies; Structure; Technology; Tendinopathy; Tendon structure; Testing; Tissues; Translations; Universities; cost; disability; effective therapy; experience; human subject; in vivo; innovation; interest; multidisciplinary; new technology; older patient; programs; translational impact

The Achilles Tendinopathy Center of Research Translation (AT-CORT) at the University of Pennsylvania will foster fundamental discovery research to guide translation, as well as employ and develop translational resources, models and technologies, to address the highly significant research and unmet clinical challenge of Achilles tendinopathy. Despite the high frequency and increasing prevalence of tendinopathy to young and old patients alike, the significant pain and disability, as well as the associated high cost to society, evaluation and development of effective treatment modalities is hindered by the lack of fundamental guiding data on the mechanobiology of tendon etiology and pathogenesis. At the University of Pennsylvania, we are uniquely positioned with a critical mass of multidisciplinary scientists and clinicians with strong interest and expertise in these and related areas. The Center’s efforts will span from the nucleus, to the cell, to the tissue, to in vivo animal models and to living human subjects in a coordinated “back-and-forth” manner across scales to guide innovative approaches to Achilles tendinopathy. The Center’s research will discover fundamental physiologic processes to guide translation. It will also as serve as a test bed for defining the role, as well as the scientific and translational rigor, of a repetitive use Achilles tendinopathy animal model through implementation of an exciting series of in vivo longitudinal assays to be conducted in parallel in both animal and human subjects. The Specific Aims of this Administrative Core are to: Aim 1: Provide leadership for Center components and activities and advise the Center Director regarding current or potential future activities of the Center; Aim 2: Manage, evaluate and monitor the Center components and activities; Aim 3: Communicate the Center’s activities to the scientific, clinical, and lay communities; Aim 4: Administer the Pilot and Feasibility Grant Program and its associated funding and reporting; and Aim 5: Implement an Enrichment Program. The Core and Research Projects have been carefully developed in concert to bridge the fundamental and applied while being highly interactive. With regular guidance from our Committee structure (External Advisory, Executive, Communication, Enrichment), we will adapt our efforts to address our translational theme in the most efficient, effective, and productive manner possible. Our Pilot and Feasibility Grant program will foster new and innovative project directions consistent with our theme as well as support development of novel technologies to bring to our projects and for translation of our efforts. Our approach will serve as a critical paradigm for other tendon and indeed other musculoskeletal disorders and we will build on these efforts. A well organized and well-structured Administrative Core is absolutely essential to accomplish the Aims of the Center’s highly interdisciplinary and interactive Research Projects and Core, and to maximize research activity, efficiency, productivity, communication, and ultimate impactful translation of our efforts to the scientific and lay community.

宾夕法尼亚大学的跟腱病研究翻译中心（AT-CORT）将 促进基础发现研究，以指导翻译，以及使用和发展翻译 资源，模型和技术，以解决高度重要的研究和未满足的临床挑战， 跟腱病。尽管肌腱病的发生率高，而且在年轻人和老年人中的患病率越来越高， 患者一样，严重的疼痛和残疾，以及相关的社会、评估和 有效治疗模式的发展受到缺乏基本指导数据的阻碍， 肌腱病因和发病机制的机械生物学。在宾夕法尼亚大学，我们是独一无二的 拥有大量多学科科学家和临床医生，他们对以下方面有浓厚的兴趣和专业知识： 及相关领域。该中心的工作范围将从细胞核、细胞、组织到体内 动物模型和活的人类受试者以协调的“来回”方式跨尺度指导 跟腱病的创新方法。该中心的研究将发现基本的生理 引导翻译的过程。它也将作为一个测试平台，用于定义角色，以及科学的 和平移僵硬，重复使用跟腱病动物模型，通过实施 在动物和人类受试者中平行进行的一系列令人兴奋的体内纵向测定。 本行政核心的具体目标是：目标1：为中心各组成部分提供领导， 活动，并就中心当前或未来可能的活动向中心主任提供建议;目标2： 管理、评估和监督中心的组成部分和活动;目标3：传达中心的 目标4：管理试点和可行性补助金 目标5：实施一项充实方案。核心 和研究项目已经精心制定了一致的桥梁基础和应用，而 高度互动。在我们的委员会结构（外部咨询，执行， 沟通，丰富），我们将调整我们的努力，以解决我们的翻译主题，在最有效的， 有效和富有成效的方式。我们的试点和可行性补助金计划将促进新的和 与我们的主题一致的创新项目方向，并支持新技术的开发， 为我们的项目和翻译我们的努力。我们的方法将作为其他方法的重要范例。 肌腱和其他肌肉骨骼疾病，我们将在这些努力的基础上再接再厉。组织良好， 一个结构良好的行政核心是绝对必要的，以实现中心的目标，高度 跨学科和互动的研究项目和核心，并最大限度地提高研究活动，效率， 生产力，沟通，并最终有效地将我们的努力转化为科学和非专业 社区