JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN) - Development Core

项目概要-核心 JHU NIMH中心发展核心的建立是为了促进创新，高风险，高影响力 通过使用试点项目赠款进行神经艾滋病毒研究。在开发核心的整个生命周期中，46 试点项目为这类研究提供了资金。获奖者随后发表了137篇直接与 他们的试点资金，并获得了超过1800万美元的后续奖励。以符合 中心优先发展威尔斯亲王医院中枢神经系统并发症的治疗方法， 为配合发展，我们建议推行三项新措施：1）设立网上试验拨款数据库 扩大评审员的参与和职业发展监测; 2）启动小额赠款资助计划 资助NeuroHIV领域的尖端技术进步和最新发展;以及3）发起一项 社区科学教育计划和社区参与演讲者系列，以促进发展 科学家谁可以谈论他们的研究的意义的方式，教育，从事，并提供 让我们的艾滋病毒社区成员有机会参与。虽然最新数据显示， 正在为早期阶段和新的调查人员提供支持，因为他们在职业生涯中取得了进展， 独立调查人员，仍然需要有针对性的减轻妇女和 少数族裔受训人员人数不足。通过这些新举措以及与临床 核心，我们预计在未来五年内加强试点赠款管理程序，提高一个- NIMH中心之间在新药开发方面的一对一指导和合作机会 针对病毒抑制的HIV感染者的CNS并发症。

PROJECT SUMMARY – DEVELOPMENTAL CORE The JHU NIMH Center Developmental Core was established to promote innovative, high-risk, high-impact NeuroHIV research through the use of Pilot Project Grants. Through the lifecycle of the Developmental Core, 46 pilot projects have funded this type of research. Awardees subsequently published 137 articles directly linked to their pilot funding and obtained over $18 million dollars in subsequent follow-up awards. To align with the Center’s priorities of developing therapeutics for the CNS complications in PWH and to enhance workforce development, we propose the implementation of three new initiatives: 1) establish an online pilot grant dashboard to broaden reviewer participation and career development monitoring; 2) initiate a microgrant funding program to fund cutting-edge technological advances and latest developments in the NeuroHIV field; and 3) initiate a community science education program and a community engagement speaker series to foster the development of scientists who can talk about the significance of their research in a manner that educates, engages, and offers opportunity for participation from members in our HIV community. While most recent data shows that progress is being made in providing support to early stage and new investigators as they advance in their careers to independent investigators, there continues to be a need for directed mitigation strategies for women and underrepresented minority trainees. With these new initiatives as well as close collaboration with the Clinical Core, we expect to over the next five years to strengthen the pilot grant administration process, enhance one- to-one mentoring and opportunities for collaboration between NIMH Centers on novel drug development targeting CNS complication in virally suppressed people with HIV.