JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN) - Development Core

项目摘要--发展核心 JHU NIMH中心开发核心的建立是为了促进创新、高风险、高影响 通过使用试点项目补助金进行神经艾滋病毒研究。通过发展核心的生命周期，46 试点项目为这类研究提供了资金。获奖者随后发表了137篇直接与 他们获得了试点资金，并在随后的后续奖励中获得了1800多万美元。要与 威尔斯亲王中心发展中枢神经系统并发症治疗的优先事项和加强劳动力 为促进发展，我们提议实施三项新举措：1)建立在线试点赠款仪表板 扩大评审员参与和职业发展监测；2)启动小额赠款资助计划 资助神经艾滋病毒领域的尖端技术进步和最新发展；以及3)发起 社区科学教育计划和社区参与演讲者系列，以促进发展 以一种教育、参与和提供的方式谈论他们研究的意义的科学家 为我们艾滋病毒社区的成员提供参与的机会。虽然最新的数据显示， 正在为早期和新的调查人员提供支持，因为他们在职业生涯中前进到 独立调查人员，继续需要针对妇女和 代表不足的少数族裔受训人员。通过这些新举措以及与临床中心的密切合作 核心，我们预计在未来五年内加强试点拨款管理程序，加强一项- NIMH中心在新药开发方面的一对一指导和合作机会 针对病毒抑制的HIV感染者的中枢神经系统并发症。

PROJECT SUMMARY – DEVELOPMENTAL CORE The JHU NIMH Center Developmental Core was established to promote innovative, high-risk, high-impact NeuroHIV research through the use of Pilot Project Grants. Through the lifecycle of the Developmental Core, 46 pilot projects have funded this type of research. Awardees subsequently published 137 articles directly linked to their pilot funding and obtained over $18 million dollars in subsequent follow-up awards. To align with the Center’s priorities of developing therapeutics for the CNS complications in PWH and to enhance workforce development, we propose the implementation of three new initiatives: 1) establish an online pilot grant dashboard to broaden reviewer participation and career development monitoring; 2) initiate a microgrant funding program to fund cutting-edge technological advances and latest developments in the NeuroHIV field; and 3) initiate a community science education program and a community engagement speaker series to foster the development of scientists who can talk about the significance of their research in a manner that educates, engages, and offers opportunity for participation from members in our HIV community. While most recent data shows that progress is being made in providing support to early stage and new investigators as they advance in their careers to independent investigators, there continues to be a need for directed mitigation strategies for women and underrepresented minority trainees. With these new initiatives as well as close collaboration with the Clinical Core, we expect to over the next five years to strengthen the pilot grant administration process, enhance one- to-one mentoring and opportunities for collaboration between NIMH Centers on novel drug development targeting CNS complication in virally suppressed people with HIV.