Developmental Core

发展核心项目摘要(见说明)： 发展核心的目标是：1)促进创新假设驱动的、高风险、高影响的神经艾滋病研究，目的与NIMH的使命相关；2)促进新型跨学科合作；3)鼓励新的和现有的研究人员参与；4)产生数据和出版物，用于申请NIH和其他同行基金。发展核心在很大程度上成功地实现了这些目标：在资助的18个试点赠款中，83%给了新的调查人员，5/13名获奖者根据他们的试点数据获得了后来的NIH或其他赠款，到目前为止发表了9篇摘要和5本出版物，被引用了22次。在本报告中，我们提供了关于这一核心取得的进展的具体细节。其中几个资助的试点项目是具有神经科学不同领域专业知识的研究人员之间的合作，在少数情况下，是跨学科性质的。在一次合作中，产生的试点数据有助于推动治疗核心的目标，并导致为其他计划项目赠款(Shin/Steiner)提供初步数据。该试点计划支持了神经艾滋病领域各个领域的研究，包括分子和细胞神经科学、临床、神经成像和动物研究，从而利用了约翰·霍普金斯大学教员的专业知识。一个试点项目侧重于使用神经成像(Mohamed)研究衰老和HIV相关神经认知障碍之间的关系，而另一个项目旨在了解手中脑内皮细胞(SFINS)的激活，这既是神经艾滋病研究的及时领域，也是新兴领域。通过JHU NIMH中心成员的建议和协助，试点获奖者利用了MACS和SHCS队列(Vissidi)的宝贵资源。试点赠款允许追求新的方向，重点放在受指导的学术指导下的风险最高的人群，否则可能由于缺乏资金而无法实现(Gamaldo)。我们预计，随着更多最近资助的项目结出硕果，成熟项目继续增长，开发核心对JHU研究能力的全面影响将得到实现。

DEVELOPMENTAL CORE PROJECT SUMMARY (See instructions): The objectives of the Developmental Core are to: 1) promote innovative hypothesis driven, high-risk, high impact neuroaids research with aims relevant to the mission of NIMH; 2) promote new kinds of cross disciplinary collaborations; 3) to encourage the participation of new and established investigators and 4) to generate data and publications for use in applying for NIH and other peer funding. The Developmental Core has been largely successful in accomplishing these aims: Out of 18 pilot grants funded, 83% went to new investigators, 5/13 awardees have received subsequent NIH or other grants based on their pilot data, nine abstracts and five publications were published with 22 citations thus far. In this report we provide specific detail regarding the progress achieved by this Core. Several of the funded pilot projects have been collaborations between investigators with expertise in distinct areas of neuroscience and in a few cases, interdisciplinary in nature. In one collaboration, pilot data generated helped to further the aims of the Therapuetic Core and led to preliminary data for other program project grants (Shin/Steiner). The pilot program supported studies in a variety of areas in the neuroAIDS field including molecular, and cellular neuroscience, clinical, neuroimaging and animal studies thereby taking advantage of the expertise of the faculty at Johns Hopkins. One pilot project is focused on examining the relationship between aging and HIV associated neurocognitive disorder using neuroimaging (Mohamed), while another aims to understand the activation of brain endothelium in HAND (Sfins), both timely and emerging areas of investigation in neuroaids. Through the suggestions and assistance of members of the JHU NIMH Center, pilot awardees used the valuable resources of the MACS, and SHCS cohorts (Viscidi). The pilot grants allowed the pursuit of novel directions with a focus on the most at-risk populations under guided academic mentoring that might not otherwise have been accomplished due to lack of funds (Gamaldo). We expect that the full impact of the Development Core on the research capacity of JHU will be realized as more recently funded projects come to fruition and mature projects continue to grow.