Developmental Core

基本核心项目总结（参见说明）： 发展核心的目标是：1）促进创新的假设驱动，高风险，高影响力的neuroaids研究，其目的与NIMH的使命相关; 2）促进新型的跨学科合作; 3）鼓励新的和建立的研究人员的参与和4）生成用于申请NIH和其他同行资助的数据和出版物。发展核心在很大程度上成功地实现了这些目标：在资助的18个试点赠款中，83%流向了新的研究人员，5/13的获奖者根据他们的试点数据获得了随后的NIH或其他赠款，到目前为止，发表了9篇摘要和5篇出版物，引用了22次。在本报告中，我们提供了关于该核心所取得进展的具体细节。几个资助的试点项目已经在神经科学的不同领域的专业知识和在少数情况下，跨学科性质的研究人员之间的合作。在一次合作中，产生的试点数据有助于进一步实现治疗核心的目标，并为其他计划项目赠款提供了初步数据（Shin/Steiner）。该试点计划支持在neuroAIDS领域的各种领域的研究，包括分子和细胞神经科学，临床，神经影像学和动物研究，从而利用约翰霍普金斯学院的专业知识。一个试点项目的重点是使用神经成像（Mohamed）检查衰老与艾滋病毒相关的神经认知障碍之间的关系，而另一个项目的目的是了解HAND（Sfins）中脑内皮细胞的激活，这是神经艾滋病研究的及时和新兴领域。通过JHU NIMH中心成员的建议和帮助，试点获奖者使用了MACS和SHCS队列（Viscidi）的宝贵资源。试点赠款允许追求新的方向，重点是最危险的人群在指导学术辅导，否则可能无法完成，由于缺乏资金（Gamaldo）。我们预计，随着最近资助的项目取得成果，成熟项目继续增长，JHU研究能力的发展核心的全面影响将得以实现。

DEVELOPMENTAL CORE PROJECT SUMMARY (See instructions): The objectives of the Developmental Core are to: 1) promote innovative hypothesis driven, high-risk, high impact neuroaids research with aims relevant to the mission of NIMH; 2) promote new kinds of cross disciplinary collaborations; 3) to encourage the participation of new and established investigators and 4) to generate data and publications for use in applying for NIH and other peer funding. The Developmental Core has been largely successful in accomplishing these aims: Out of 18 pilot grants funded, 83% went to new investigators, 5/13 awardees have received subsequent NIH or other grants based on their pilot data, nine abstracts and five publications were published with 22 citations thus far. In this report we provide specific detail regarding the progress achieved by this Core. Several of the funded pilot projects have been collaborations between investigators with expertise in distinct areas of neuroscience and in a few cases, interdisciplinary in nature. In one collaboration, pilot data generated helped to further the aims of the Therapuetic Core and led to preliminary data for other program project grants (Shin/Steiner). The pilot program supported studies in a variety of areas in the neuroAIDS field including molecular, and cellular neuroscience, clinical, neuroimaging and animal studies thereby taking advantage of the expertise of the faculty at Johns Hopkins. One pilot project is focused on examining the relationship between aging and HIV associated neurocognitive disorder using neuroimaging (Mohamed), while another aims to understand the activation of brain endothelium in HAND (Sfins), both timely and emerging areas of investigation in neuroaids. Through the suggestions and assistance of members of the JHU NIMH Center, pilot awardees used the valuable resources of the MACS, and SHCS cohorts (Viscidi). The pilot grants allowed the pursuit of novel directions with a focus on the most at-risk populations under guided academic mentoring that might not otherwise have been accomplished due to lack of funds (Gamaldo). We expect that the full impact of the Development Core on the research capacity of JHU will be realized as more recently funded projects come to fruition and mature projects continue to grow.