Neonatal Functional Connectivity Associated with Callous-Unemotional Behaviors in Preschoolers

新生儿功能连接与学龄前儿童冷酷无情的行为相关

• 批准号: 10477982
• 负责人: REBECCA BRENNER
• 金额: $ 3.52万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10477982
• 关键词: 3 year old; Address; Adolescent; Affect; Affective; Age; Aggressive behavior; Amygdaloid structure; Anterior; Area; Base of the Brain; Behavior; Behavior assessment; Biological; Birth; Brain; Child; Child Development; Child Rearing; Code; Conduct Disorder; Data; Data Collection; Development; Dimensions; Disease; Early Intervention; Educational Status; Emotional; Emotions; Empathy; Environmental Exposure; Environmental Risk Factor; Equipment and supply inventories; Fathers; Functional Magnetic Resonance Imaging; Functional disorder; Genes; Genetic; Guilt; Heritability; Impairment; Infant; Insula of Reil; Light; Link; Longitudinal Studies; Longitudinal cohort; Measures; Mediating; Mediation; Mental Health; Mentorship; Methods; Modeling; Mothers; Neonatal; Neurotransmitter Receptor; Neurotransmitters; Newborn Infant; Nursery Schools; Parents; Pathology; Patient Self-Report; Patients; Physicians; Prefrontal Cortex; Prognosis; Psychopathology; Questionnaires; Research; Rest; Risk; Role; Sampling; Scientist; Specificity; Substance Use Disorder; Symptoms; Testing; Toddler; Twin Studies; Variant; Work; adverse outcome; antisocial behavior; base; callous unemotional trait; career; cingulate cortex; cohort; comorbidity; conduct problem; early childhood; emotion regulation; experience; genetic variant; high risk; improved; insight; maternal stress; neonatal brain; neonatal magnetic resonance imaging; neonatal period; neonate; neuroimaging; novel; offspring; postnatal; prenatal; programs; prospective; prospective test; psychopathic personality; recruit; relating to nervous system; skills; social; socioeconomic adversity; treatment response

Project Summary Children with Callous-Unemotional (CU) traits, which are defined by impairments in empathy, prosociality, and guilt, represent a uniquely at-risk subset of children with conduct disorder. These children have worse prognoses and response to treatments than children with conduct disorder alone. As a result, many of them suffer from poor educational achievement, substance use disorders, and antisocial behaviors. Genetic and environmental factors both affect the development of CU traits, which can occur as early as age 3 years. Twin studies place the heritability of CU traits around 58-81%, with the most implicated genes coding for neurotransmitter receptor variants. Due to the potential genetic effect on brain development, prior studies in adolescents have investigated and found alterations in emotion processing and emotion regulation areas of the brain. However, it is unknown whether these brain changes precede the early development of CU traits or occur later as a result of the pathology. To address this gap, we will leverage a unique, prospective, longitudinal cohort of 385 mother-infant dyads (recruited through R01 MH113883) that includes state-of-the-art neonatal neuroimaging, parental measures of CU traits (added by the applicant), and measures of offspring CU traits at age 3 years (added by the applicant). We hypothesize that altered functional brain connectivity in the newborn period, which occurs prior to postnatal environmental exposures, will mediate the heritable link between parent’s and children’s CU traits. To test this hypothesis, we plan to link CU traits in both mothers and fathers to CU traits in their children at age 3 years. Second, we will explore the relationship between neonatal functional connectivity in emotion processing and emotion regulation regions and CU traits at age 3 years. Finally, we will examine the role of neonatal functional connectivity in mediating heritable relationships between parent and children CU traits. Critically, this proposed project builds upon the candidate’s strong background and experience in neuroimaging analyses and behavioral assessments, enabling development of new skills across the domains of quantitative methods and atypical child development. Finally, not only will this project improve the understanding of aberrant brain development underlying early CU traits, but it will also provide the necessary background for the candidate to become a highly successful academic physician-scientist investigating the biological underpinnings of CU traits and treating patients with externalizing disorders.

项目摘要 具有冷酷无情（CU）特征的儿童，这些特征是由同理心，亲社会性和 内gui，代表了有行为障碍儿童的独特风险子集。这些孩子的预后较差 和对治疗的反应比仅有行为障碍的儿童。结果，他们中的许多人遭受贫穷 教育成就，药物使用障碍和反社会行为。遗传和环境因素 两者都会影响铜质特征的发展，这可能早在3岁时就会发生。双胞胎研究将 CU性状的遗传力约为58-81％，最暗示的基因编码神经递质接收器 变体。由于潜在的遗传对大脑发育的影响，已经研究了青少年的先前研究 并发现情绪处理和大脑情绪调节领域的变化。但是，这是未知的 这些大脑是在CU性状的早期发展之前还是在以后发生 病理。 为了解决这一差距，我们将利用385个母亲的独特，前瞻性，纵向队列 （通过R01 MH113883招募），包括最先进的新生儿神经影像学，父母的措施 CU特征（申请人添加），以及3岁时的后代Cu特征的度量（由申请人添加）。 我们假设在新生儿时期发生的功能性大脑连通性改变了，这发生在产后之前 环境暴露将调解父母和孩子的铜质特征之间可遗传的联系。测试这个 假设，我们计划将母亲和父亲的CU特征与3岁的孩子的CU特征联系起来。 其次，我们将探讨情感处理中新生儿功能连接与 3岁时的情绪调节区域和CU特征。最后，我们将研究新生儿功能的作用 在调解父母和子女之间可遗传关系的连通性cu特征。 至关重要的是，这个拟议的项目以候选人在神经影像方面的强大背景和经验为基础 分析和行为评估，从而在定量的整个领域中发展新技能 方法和非典型儿童发展。最后，这个项目不仅会改善对异常的理解 早期CU特征的脑发育，但它也将为候选人提供必要的背景 成为一名非常成功的学术身体科学家，调查了Cu的生物基础 特征和治疗外在疾病的患者。