Contributions of Hypoglycemia and Hyperglycemia to Adverse Geriatric Outcomes in NH Residents with Diabetes and Alzheimer's Disease and Related Dementias (ADRD)
低血糖和高血糖对患有糖尿病、阿尔茨海默病和相关痴呆 (ADRD) 的新罕布什尔州居民老年不良结局的影响
基本信息
- 批准号:10477334
- 负责人:
- 金额:$ 13.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdultAffectAgingAlzheimer&aposs disease related dementiaAttentionBehaviorBlood GlucoseCaregiversCaringClinicalCognitionComplexCrossover DesignDataData SetDatabasesDementiaDiabetes MellitusDoctor of PhilosophyElderlyElectronic Health RecordEnvironmentEpidemiologistEpidemiologyExpert OpinionFoundationsFrail ElderlyFundingGeriatric AssessmentGeriatricsGlucoseGoalsGuidelinesHealthHealth ServicesHyperglycemiaHypoglycemiaImpaired cognitionIncidenceIncontinenceInsulinLinkMeasurementMeasuresMedicalMentored Research Scientist Development AwardMentorsMentorshipMethodologyMethodsNeurologyNon-Insulin-Dependent Diabetes MellitusNursing HomesOutcomePoliciesPopulationPsychiatryQuality of CareQuality of lifeRecommendationResearchResearch DesignResearch PersonnelRiskSeveritiesSourceStructural ModelsSymptomsSyndromeSystemTestingTimeTrainingUnited States Department of Veterans AffairsUniversitiesUrinary tract infectionVulnerable Populationsbasecareercareer developmentclinical carecognitive functioncomorbiditydiabetes managementevidence baseexperiencefallsfunctional declinehigh riskhuman old age (65+)improvedmid-career facultymultiple chronic conditionsprofessorskills
项目摘要
Project Summary/Abstract
Nursing home (NH) residents with type 2 diabetes have substantial multimorbidity that complicates diabetes
management. Alzheimer's Disease and related dementias affects nearly 50% of NH residents and may
increase risk of hypoglycemia. Current NH diabetes management guidelines do not address Alzheimer's
Disease and related dementias and current recommendations for NH target blood glucose ranges are based
on expert opinion rather than evidence of adverse geriatric outcomes at certain thresholds of glycemia. To
address these weaknesses, we propose the following aims: 1) to compare the incidence rates of hypo- and
hyper-glycemia in the NH by dementia status, 2) to examine the acute effects of hypo- and hyper-glycemia on
geriatric syndromes and evaluate whether Alzheimer's Disease and related dementias modifies glycemic
thresholds, and 3) to examine the cumulative effects of hypo- and hyper-glycemia on cognitive decline and
functional decline, and to determine whether baseline severity of Alzheimer's Disease and related dementias
modifies glycemic thresholds. The proposed research leverages existing Veterans Affairs electronic health
record databases, a unique source of routine fingerstick glucose measurements. The long-term goal of this
research is to establish NH-specific target blood glucose ranges with thresholds of hypoglycemia and
hyperglycemia that account for the presence of Alzheimer's Disease and related dementias. Dr. Lee seeks a
K01 Mentored Research Scientist Development Award to obtain essential skills and mentored research
experience that will launch her career as an independent investigator in the field of aging, diabetes, and
Alzheimer's Disease and related dementias. The five-year training plan will fill content gaps in geriatric
syndromes and the assessment of Alzheimer's Disease and related dementias while building on her
methodological strengths to include advanced causal inference methods and using electronic health records
for research. Dr. Lee will complete the proposed research in the rich training environment of the UCSF Division
of Geriatrics, with primary mentorship from geriatrics health services researcher Dr. Sei Lee, MD, MAS,
Professor of Geriatrics at UCSF, co-mentorship by dementia expert Dr. Kristine Yaffe, MD, Professor of
Psychiatry, Neurology and Epidemiology at UCSF, and aging epidemiologist Dr. Michelle Odden, PhD,
Associate Professor of Epidemiology in the Division of Health Research and Policy at Stanford University. With
the support of her mentors, co-mentors, and esteemed advisors, Dr. Lee will advance towards successfully
competing for R01 funding and becoming a leader in geriatric diabetes.
项目概要/摘要
患有 2 型糖尿病的疗养院 (NH) 居民患有多种疾病,导致糖尿病复杂化
管理。阿尔茨海默病和相关痴呆症影响着新罕布什尔州近 50% 的居民,并且可能
增加低血糖的风险。目前的 NH 糖尿病管理指南并未针对阿尔茨海默病
疾病和相关痴呆症以及当前 NH 目标血糖范围的建议基于
基于专家意见,而不是在某些血糖阈值下不良老年结局的证据。到
为了解决这些弱点,我们提出以下目标:1)比较低血压和低血压的发生率
NH 中的高血糖(按痴呆状态),2) 检查低血糖和高血糖对
老年综合症并评估阿尔茨海默氏病和相关痴呆症是否会改变血糖
阈值,3) 检查低血糖和高血糖对认知能力下降的累积影响
功能衰退,并确定阿尔茨海默病和相关痴呆症的基线严重程度
改变血糖阈值。拟议的研究利用现有退伍军人事务部电子健康
记录数据库,常规指尖血糖测量的独特来源。本次活动的长远目标
研究的目的是建立 NH 特定的目标血糖范围以及低血糖阈值和
高血糖是导致阿尔茨海默病和相关痴呆症的原因。李博士寻求
K01 指导研究科学家发展奖,以获得基本技能和指导研究
这段经历将开启她作为衰老、糖尿病和糖尿病领域的独立研究者的职业生涯。
阿尔茨海默病和相关痴呆症。五年培训计划将填补老年医学领域的内容空白
综合症以及阿尔茨海默病和相关痴呆症的评估,同时以她为基础
方法论优势包括先进的因果推理方法和使用电子健康记录
用于研究。 Lee博士将在UCSF分部丰富的培训环境中完成拟议的研究
老年病学部,主要由老年病学健康服务研究员 Sei Lee 博士(医学博士、MAS)指导,
加州大学旧金山分校老年病学教授,由痴呆症专家 Kristine Yaffe 博士(医学博士、教授)共同指导
加州大学旧金山分校精神病学、神经病学和流行病学以及老龄流行病学家 Michelle Odden 博士
斯坦福大学健康研究与政策部流行病学副教授。和
在导师、共同导师和尊敬的顾问的支持下,李博士将迈向成功
竞争 R01 资金并成为老年糖尿病领域的领导者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alexandra Kathryn Lee其他文献
Alexandra Kathryn Lee的其他文献
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{{ truncateString('Alexandra Kathryn Lee', 18)}}的其他基金
Contributions of Hypoglycemia and Hyperglycemia to Adverse Geriatric Outcomes in NH Residents with Diabetes and Alzheimer's Disease and Related Dementias (ADRD)
低血糖和高血糖对患有糖尿病、阿尔茨海默病和相关痴呆 (ADRD) 的新罕布什尔州居民老年不良结局的影响
- 批准号:
10282443 - 财政年份:2021
- 资助金额:
$ 13.2万 - 项目类别:
Contributions of Hypoglycemia and Hyperglycemia to Adverse Geriatric Outcomes in NH Residents with Diabetes and Alzheimer's Disease and Related Dementias (ADRD)
低血糖和高血糖对患有糖尿病、阿尔茨海默病和相关痴呆 (ADRD) 的新罕布什尔州居民老年不良结局的影响
- 批准号:
10646499 - 财政年份:2021
- 资助金额:
$ 13.2万 - 项目类别:
Admin Supplement for Retention of K Awardees: Contributions of Hypoglycemia and Hyperglycemia to Adverse Geriatric Outcomes in NH Residents
保留 K 获奖者的行政补充:低血糖和高血糖对新罕布什尔州居民老年不良结果的影响
- 批准号:
10614349 - 财政年份:2021
- 资助金额:
$ 13.2万 - 项目类别:
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