Analytics and Synthesis Core

项目摘要 烟草监管科学(TRS)的新发现正在迅速出现，但将这些 在更强有力的研究实践和政策方面取得进展面临巨大挑战，包括综合 并将这些调查结果传播到各种利益攸关方手中。此外，由于烟草产品 地貌继续演变，需要新的TRS研究，以及进一步的整合，以帮助 FDA的监管行动。一个强大的协调中心，作为TRS研究人员的枢纽和连接器，是 对克服这些挑战和促进有效的TRS研究至关重要。我们已经设计了我们的 分析、科学、改进和物流协调中心(CASEL)应对挑战 面对这种快速变化的环境和不断扩大的知识库。我们的具体目标是：(1)服务 作为TRS的科学研究协调员，通过促进合作和传播来推动 为制定CTP规则提供科学和信息；并通过支持通过协商一致的方法和措施， 数据共享、综合；(2)促进沟通、协调，加快TRS进程 信息共享机会，并使TRS社区容易获得研究资源； (3)通过支持职业提升，增强研究人员进行有影响力的研究的能力 在CTP资助的研究界开展活动；(4)建立后勤和管理基础设施 高效有效地协调各种TRS研究组合；(5)提供科学专门知识 有助于确定研究需求和与之合作的手段 联邦合作伙伴和研究界解决这些问题；以及(6)充当NIH、CTP、 和烟草监管科学中心(TCORS)，以提高和加快产量，并促进 实施快速反应项目，以解决高度优先的问题。我们将通过一个 建立在我们经验丰富的科学和管理领导力基础上的协作结构，发展良好 基础设施，以及将不同的团队聚集在一起的能力，使CASEL成为一个成功和支持的合作伙伴 在推进TRS方面。我们举办了前身评估和协调培训中心， 研究(CECTR)，因此拥有丰富的资源、经验、组织和成熟的TRS 网络无缝地进入CASEL，以增强和扩展我们的计划，并引入细致入微的 我们的方法进行了有效的创新。珍妮·罗森塔尔和罗宾·梅梅尔斯坦博士将担任联合PI和 领导核心和物流核心，提供高水平的管理和国家认可 分别是科学领导。我们经验丰富的核心领导Howard Fishbein博士(分析和 综合)、艾米·索利斯女士(职业提升)和卡桑德拉·斯坦顿博士(传播)将提供 有效和知识渊博的监督，以满足每个核心的具体目标。我们汇聚了一个广泛的 一系列的合作者，以创造一个理想的环境，以促进和促进进行高质量的TRS。

PROJECT ABSTRACT New discoveries in Tobacco Regulatory Science (TRS) are occurring at a rapid pace, but translating these advances into more robust research practices and policy faces enormous challenges, including the synthesis and dissemination of these findings to reach a variety of stakeholders. In addition, as the tobacco product landscape continues to evolve, new TRS research is needed, as well as further integration to help inform the FDA’s regulatory actions. A strong coordinating center, serving as a hub and connector for TRS researchers, is critical to overcoming these challenges and to promoting effective TRS research. We have designed our Center for Coordination of Analytics, Science, Enhancement and Logistics (CASEL) to address challenges faced by this rapidly changing environment and expanding knowledge base. Our specific aims are to: (1) Serve as the scientific research coordinator for TRS by facilitating collaboration and dissemination to advance the science and inform CTP rule-making; and by supporting the adoption of consensus methods and measures, data sharing, and synthesis; (2) Accelerate the progress of TRS by fostering communication, coordinating information-sharing opportunities, and making research resources readily accessible to the TRS community; (3) Enhance the capacity of researchers to conduct impactful research by supporting career enhancement activities across the CTP-funded research community; (4) Establish a logistical and management infrastructure for efficient and effective coordination of a diverse portfolio of TRS research; (5) Provide the scientific expertise and perspective to contribute to the identification of research needs and the means to work cooperatively with Federal partners and the research community to address them; and (6) Serve as a conduit between NIH, CTP, and the Tobacco Centers of Regulatory Science (TCORS) to enhance and accelerate output and facilitate the conduct of rapid response projects to address high-priority questions. We will accomplish these aims with a collaborative structure that builds on our experienced scientific and management leadership, well-developed infrastructure, and ability to bring diverse teams together to make CASEL a successful and supportive partner in advancing TRS. We have held the predecessor Center for Evaluation and Coordination of Training and Research (CECTR), and thus have a wealth of resources, experience, organization, and an established TRS network to step into CASEL seamlessly, to enhance and expand our initiatives, and to introduce nuanced, effective innovation in our approaches. Jeanne Rosenthal and Dr. Robin Mermelstein will serve as Co-PIs and leaders of the Leadership and Logistics Core, providing high-level management and nationally recognized scientific leadership respectively. Our highly experienced Core Leads, Dr. Howard Fishbein (Analytics and Synthesis), Ms. Amy Solis (Career Enhancement), and Dr. Cassandra Stanton (Dissemination), will provide effective and knowledgeable oversight to meet each core’s specific aims. We have brought together a wide range of collaborators to create an ideal environment to foster and promote the conduct of high quality TRS.