Clinical Core

项目摘要/摘要： 这个P30应用程序的一个关键基础组件是个性化临床核心，它将是 人体细胞、组织、体液的主要来源[例如：痰、支气管肺泡灌洗液(BALF)、汗液、 [血清]和翻译研究专业知识。个性化临床核心直接建立在现有的基础上 CCHMC的临床研究优势和基础设施，包括CFF-TDN计划，CF-RDP 项目，研究人员发起的研究，以及机构对CF翻译研究的承诺。这个 个性化的临床核心将在关键方面扩展这些能力，专门专注于获得 患者来源的生物标本伴随着临床相关性，并提供全面的临床研究 将新颖的翻译研究项目付诸实施的能力。个性化的临床核心意志 协调人体标本的采购、扩展、储存和分发，并提供 有适当临床研究支持的翻译研究人员执行和解释临床 调查。这个P30核心的愿景是通过提供以下内容来加强校园内以CF为重点的研究 来自CF患者的具有良好特征的、高质量的、仅供人类使用的样本和适当的非 Cf控制。通过个性化临床核心结构集中这些能力将有助于 推动研究效率和标准化。此外，通过提取和处理的样本 个性化临床核心将可供CF研究人员直接使用，也可用于使用 个性化模型系统核心和CF呼吸道上皮细胞核心图谱。

PROJECT SUMMARY/ABSTRACT: A key foundational component of this P30 application is the Personalized Clinical Core, which will be the primary source of human cells, tissues, biofluids [e.g.: sputum, bronchoalveolar lavage fluid (BALF), sweat, serum] and translational research expertise. The Personalized Clinical Core builds directly on current clinical research strengths and infrastructure at CCHMC, including the CFF-TDN program, the CF-RDP program, investigator-initiated research, and institutional commitments to CF translational research. The Personalized Clinical Core will expand these capabilities in critical ways, focusing exclusively on obtaining patient-derived biospecimens accompanied by clinical correlates, and providing full clinical research capabilities to operationalize novel translational research projects. The Personalized Clinical Core will coordinate the procurement, expansion, banking, and distribution of human specimens, and provide translational researchers with appropriate clinical research support to execute and interpret clinical investigation. The vision of this P30 Core is to enhance the CF-focused research on campus by provision of well-characterized, high quality and human-only samples from CF patients and appropriate non- CF controls. Centralizing these capabilities through the Personalized Clinical Core structure will help to drive research efficiencies and standardization. In addition, the samples obtained and processed through the Personalized Clinical Core will be available for direct use by CF researchers, and for projects utilizing the Personalized Model Systems Core and the Atlas of the CF Respiratory Epithelial Cells Core.