Clinical Core

项目总结/摘要： 该P30应用程序的一个关键基础组件是个性化临床核心，它将是 人类细胞、组织、生物流体的主要来源[例如：痰、支气管肺泡灌洗液（BALF）、汗液 血清]和转化研究专业知识。个性化临床核心直接建立在当前 CCHMC的临床研究优势和基础设施，包括CFF-TDN计划，CF-RDP 计划，赞助商发起的研究，和机构承诺CF转化研究。的 个性化临床核心将以关键方式扩展这些功能，专注于获得 患者来源的生物标本，伴有临床相关因素，并提供完整的临床研究 有能力实施新的转化研究项目。个性化临床核心将 协调人体标本的采购、扩大、储存和分发，并提供 翻译研究人员与适当的临床研究支持，以执行和解释临床 调查这个P30核心的愿景是通过提供以下内容来加强校园内以CF为重点的研究： 来自CF患者的良好表征的、高质量的和仅人类的样品和适当的非 CF控制。通过个性化临床核心结构集中这些功能将有助于 提高研究效率和标准化。此外，通过以下方法获得和处理的样品 个性化的临床核心将可供CF研究人员直接使用，并可用于利用 个性化模型系统核心和CF呼吸道上皮细胞核心图谱。

PROJECT SUMMARY/ABSTRACT: A key foundational component of this P30 application is the Personalized Clinical Core, which will be the primary source of human cells, tissues, biofluids [e.g.: sputum, bronchoalveolar lavage fluid (BALF), sweat, serum] and translational research expertise. The Personalized Clinical Core builds directly on current clinical research strengths and infrastructure at CCHMC, including the CFF-TDN program, the CF-RDP program, investigator-initiated research, and institutional commitments to CF translational research. The Personalized Clinical Core will expand these capabilities in critical ways, focusing exclusively on obtaining patient-derived biospecimens accompanied by clinical correlates, and providing full clinical research capabilities to operationalize novel translational research projects. The Personalized Clinical Core will coordinate the procurement, expansion, banking, and distribution of human specimens, and provide translational researchers with appropriate clinical research support to execute and interpret clinical investigation. The vision of this P30 Core is to enhance the CF-focused research on campus by provision of well-characterized, high quality and human-only samples from CF patients and appropriate non- CF controls. Centralizing these capabilities through the Personalized Clinical Core structure will help to drive research efficiencies and standardization. In addition, the samples obtained and processed through the Personalized Clinical Core will be available for direct use by CF researchers, and for projects utilizing the Personalized Model Systems Core and the Atlas of the CF Respiratory Epithelial Cells Core.