Administrative Supplement - 3/3: Community Psychology Risk Screening: An Instrument Development Study
行政补充 - 3/3:社区心理风险筛查:工具开发研究
基本信息
- 批准号:10477658
- 负责人:
- 金额:$ 15.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:Administrative SupplementAdolescentAnxietyAreaAttenuatedBaltimoreCOVID-19 pandemicCannabisCatchment AreaChicagoClinicalCommunitiesCommunity PsychologyDSM-VDataData CollectionDevice or Instrument DevelopmentDimensionsEarly DiagnosisExhibitsFamily history ofIndividualInterviewInvestigationMental DepressionMental disordersOnset of illnessOutcomePhiladelphiaPopulationPopulation HeterogeneityPrevalencePreventionPsychosesPsychotic DisordersQuestionnairesRecording of previous eventsRiskRisk FactorsRuralSample SizeSamplingScreening procedureSiteStructureSymptomsSyndromeTraumaattenuated psychosis syndromebaseclinical high risk for psychosisdesignduration of untreated psychosisfollow-uphelp-seeking behaviorhigh riskpandemic diseasepsychosis riskpsychotic symptomsscreeningsubstance usesuburbtoolyoung adult
项目摘要
Project Summary/Abstract
The proposed study aims to develop a brief, valid screening questionnaire to identify individuals at risk for
psychosis in non-clinical populations across 3 large, community catchment areas with diverse populations.
This is a needed study, as the current screening tools for at-risk psychotic populations have been validated
only in clinical and/or treatment seeking samples, which are not likely to generalize beyond these specialized
settings. The proposed project will administer 3 well-known psychosis risk screeners, as well as symptom-
based (e.g., depression, anxiety, etc.) and risk-factor based questionnaires (e.g., cannabis and other
substance use, a family history of major mental disorders, trauma history) to 12,000 adolescents/young adults
in local communities across 3 demographically diverse sites (the greater Philadelphia, Baltimore, and Chicago
areas, including neighboring rural/suburban areas). Based on established cut-off scores from the 3 psychosis
screeners, 2,000 subjects deemed as questionnaire higher risk (QHR; n=1,000) and questionnaire lower risk
(QLR; n=1,000) for psychosis (estimated sample sizes based on pilot data and anticipated loss to follow up)
will be invited to complete semi-structured interviews to determine clinical high risk (CHR) for psychosis status
based on the Structured Interview for Psychosis-Risk Syndromes (SIPS) and to assess current/past major
mental disorders based on the Structured Clinical Interview for DSM-5 (SCID-5). The SIPS psychosis-risk
persistence syndromes and the DSM-5 attenuated positive syndrome (both assessed with the SIPS 5.6) also
will be collected and will be examined in supplementary analyses. Based on preliminary data and conservative
estimates, we anticipate that 186 of the QHR group will be considered CHR for psychosis. The specific aims
are as follows: 1) to determine norms and prevalence rates of attenuated positive psychotic symptoms across
3 diverse, community catchment areas and 2) to develop a screening questionnaire, inclusive of both
symptom-based and risk factor-based questions, that is validated against the SIPS to identify those at CHR for
psychosis in the community. This is the first study in the U.S. to determine the rate of subthreshold psychotic
symptoms across diverse non-help seeking samples, which is essential for any investigation that uses
dimensional approaches to psychotic disorders. Further, the proposed study will develop an essential
screening tool that will identify which individuals have the greatest need of follow-up with structured interviews
in CHR studies or clinical settings to determine psychosis-risk status. This tool is will be valuable given findings
that those who develop psychotic disorders often do not seek treatment until after the onset of the disorder,
and that duration of untreated psychosis is associated with more serious clinical outcomes. The proposed
study has the potential for major contributions to the early detection and prevention of psychotic disorders. The
supplement would help realize the full import of this project following the unprecedented COVID-19 pandemic.
项目总结/摘要
这项拟议的研究旨在开发一个简短,有效的筛选问卷,以确定个人的风险,
在3个大型社区集水区的非临床人群中,不同人群的精神病。
这是一项必要的研究,因为目前对高危精神病人群的筛查工具已经得到验证
仅在临床和/或寻求治疗的样本中,这些样本不太可能泛化到这些专业样本之外。
设置.拟议的项目将管理3个著名的精神病风险筛查,以及症状-
基于(例如,抑郁、焦虑等)和基于风险因素的问卷(例如,大麻和其他
药物使用、重大精神障碍家族史、创伤史),
在3个人口统计学上不同的地点(大费城、巴尔的摩和芝加哥)的当地社区
(包括邻近的农村/郊区)。基于3种精神病的既定临界评分
筛选者,2,000例受试者被视为问卷调查高风险(QHR; n= 1,000)和问卷调查低风险
(QLR; n= 1,000)精神病(基于试验数据和预期失访估计的样本量)
将被邀请完成半结构化访谈,以确定精神病状态的临床高风险(CRD)
基于精神病风险综合征(SIPS)的结构化访谈,并评估当前/过去的主要
根据DSM-5(SCID-5)的结构化临床访谈确定的精神障碍。SIPS精神病风险
持续性综合征和DSM-5减弱阳性综合征(均采用SIPS 5.6评估)也
将收集并在补充分析中进行检查。根据初步数据和保守估计,
估计,我们预计QHR组中有186人将被视为精神病患者。具体目标
研究内容如下:1)确定各年龄组精神病性症状减弱阳性者的常模和患病率,
3)多样化的社区集水区和2)制定一个筛选问卷,包括两者
根据SIPS验证的基于风险因素和风险因素的问题,
精神病在社区。这是美国第一项确定阈下精神病患者比率的研究。
症状在不同的非寻求帮助的样本,这是必不可少的任何调查,
精神障碍的立体治疗此外,拟议的研究将制定一项重要的
筛选工具,用于确定哪些人最需要通过结构化访谈进行后续跟进
在精神病学研究或临床环境中确定精神病风险状态。这一工具将是有价值的调查结果
那些患有精神病的人通常直到疾病发作后才寻求治疗,
精神病未治疗的持续时间与更严重的临床结果相关。拟议
这项研究有可能对精神病的早期发现和预防做出重大贡献。的
在前所未有的COVID-19疫情爆发后,该补充将有助于实现该项目的全面导入。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Measurement Invariance of Psychotic-Like Symptoms as Measured With the Prodromal Questionnaire, Brief Version (PQ-B) in Adolescent and Adult Population Samples.
- DOI:10.3389/fpsyt.2020.593355
- 发表时间:2020
- 期刊:
- 影响因子:4.7
- 作者:Lång U;Mittal VA;Schiffman J;Therman S
- 通讯作者:Therman S
Family functioning moderates the impact of psychosis-risk symptoms on social and role functioning.
家庭功能调节精神病风险症状对社会和角色功能的影响。
- DOI:10.1016/j.schres.2018.08.035
- 发表时间:2019
- 期刊:
- 影响因子:4.5
- 作者:Thompson,Elizabeth;Rakhshan,Pamela;Pitts,StevenC;Demro,Caroline;Millman,ZacharyB;Bussell,Kristin;DeVylder,Jordan;Kline,Emily;Reeves,GloriaM;Schiffman,Jason
- 通讯作者:Schiffman,Jason
Employing Contemporary Integrative Interpersonal Theory to Understand Dysfunction in Those at Clinical High Risk for Psychosis.
- DOI:10.1093/schizbullopen/sgac015
- 发表时间:2022-01
- 期刊:
- 影响因子:0
- 作者:Williams, Trevor F;Ellman, Lauren M;Schiffman, Jason;Mittal, Vijay A
- 通讯作者:Mittal, Vijay A
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Steven C Pitts其他文献
Steven C Pitts的其他文献
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{{ truncateString('Steven C Pitts', 18)}}的其他基金
3/3: Community Psychosis Risk Screening: An Instrument Development Study.
3/3:社区精神病风险筛查:仪器开发研究。
- 批准号:
10208642 - 财政年份:2017
- 资助金额:
$ 15.34万 - 项目类别:
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