Tissue regulation of T cell function - Administrative Core

项目摘要/摘要--行政核心 我们在炎症组织中操纵免疫功能的能力目前受到缺乏基本免疫功能的限制 了解细胞如何在炎症环境中发挥作用。目前减轻组织炎症的方法 重点是全面的免疫抑制或全面阻止白细胞进入组织。原则上， 这些策略可以预防疾病，但由于传染病增加而引起的并发症已被消除 热情。因此，治疗需要变得更加针对炎症，这是通过预防 招募特定类型的T细胞(阻断T细胞以产生过敏反应，但留下白细胞流入 细菌在同一组织中的完整清除)，或通过阻断特定细胞因子产生的信号。这 该计划寻求确定特定情况下对免疫功能至关重要的上下文相关事件 炎症性环境。为了实现这一目标，该计划开发了用于生命内成像的创新工具 发炎的组织。核心A的主要目标是提供行政和科学监督，以 个别项目和核心。它的科学使命是促进和创建科学交流的论坛 在项目内部，在研究所的小组和更广泛的国际科学界之间。 在行政方面，Fowell博士和行政人员之间将安排每月的会议，以确保 将与项目负责人组织良好的沟通和安全合规并每月举行会议 会计讨论个人帐目。促进科学交流，每月进行研究 将举行会议讨论个别项目的概念和技术进展，这些进展可能影响 计划作为一个整体。一年一度的“免疫成像”研讨会将从这个核心组织起来，并已 是上一个资金周期的亮点，举办了4个研讨会，吸引了该领域的领导人作为演讲者 以及强大的地方和全国上座率。我们认为这次研讨会是一种让全世界的科学家成为核子的方式 国家将讨论这一领域的挑战，并就创新技术交流意见，以促进 炎症组织中感染或自身免疫的原位研究。

PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE Our ability to manipulate immune function in inflamed tissues is currently limited by a lack of fundamental knowledge of how cells function in an inflammatory milieu. Current approaches to mitigate tissue inflammation focus on general immunosuppression or general blockade of leukocyte trafficking into tissues. In principle, these strategies prevent disease but complications due to increased infectious disease have quashed enthusiasm. Therefore, therapies need to become more inflammation-specific, be that by preventing recruitment of specific types of T cells (blocking T cells for an allergic response but leaving influx of leukocytes for bacterial clearance in the same tissue intact) or by blocking signals for specific cytokine production. This Program seeks to identify context-dependent events that are critical for immune function in specific inflammatory settings. To achieve this goal, the Program has developed innovative tools for intra-vital imaging of inflamed tissue. The major objective of Core A is to provide administrative and scientific oversight to the individual projects and Cores. Its scientific mission is to promote and create forums for scientific exchange within the Projects, between groups at the Institution and the broader international scientific community. Administratively, monthly meetings will be scheduled between Dr Fowell and the administrative staff to ensure good communication and safety compliance and monthly meetings will be organized with project leaders and the accountant to discuss individual accounts. To promote scientific exchange, monthly research-in-progress meetings will be held to discuss conceptual and technical advances in individual projects that may impact the Program as a whole. An annual “Immune Imaging” symposium will be organized from within this Core and has been the highlight of the previous funding cycle with 4 Symposia held attracting leaders in the field as speakers and a strong local and national attendance. We see this Symposium as a way to nucleate scientist across the country to discuss challenges in the field and to exchange ideas on innovative technology that will facilitate the in situ study of immunity, infectious or autoimmune, in inflamed tissues.