Tissue regulation of T cell function - Administrative Core

T 细胞功能的组织调节 - 管理核心

• 批准号: 10689171
• 负责人: Deborah J Fowell
• 金额: $ 9.06万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10689171
• 关键词: Accounting; Animals; Autoimmune; Back; Biological; Budgets; Cell physiology; Communicable Diseases; Communication; Communities; Country; Data; Discipline; Disease; Ensure; Event; Funding; Goals; Grant; Immunity; Immunosuppression; In Situ; Individual; Inflammation; Inflammatory; Institution; International; Knowledge; Leukocyte Trafficking; Leukocytes; Mission; Monitor; Occupational activity of managing finances; Postdoctoral Fellow; Production; Progress Reports; Research; Research Personnel; Safety; Schedule; Science; Scientist; Signal Transduction; Structure; Students; T cell regulation; T-Lymphocyte; Technology; Tissues; United States National Institutes of Health; Work; allergic response; cytokine; immune function; immune imaging; inflammatory milieu; innovation; innovative technologies; insight; intravital imaging; meetings; member; prevent; programs; recruit; success; symposium; synergism; tool

PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE Our ability to manipulate immune function in inflamed tissues is currently limited by a lack of fundamental knowledge of how cells function in an inflammatory milieu. Current approaches to mitigate tissue inflammation focus on general immunosuppression or general blockade of leukocyte trafficking into tissues. In principle, these strategies prevent disease but complications due to increased infectious disease have quashed enthusiasm. Therefore, therapies need to become more inflammation-specific, be that by preventing recruitment of specific types of T cells (blocking T cells for an allergic response but leaving influx of leukocytes for bacterial clearance in the same tissue intact) or by blocking signals for specific cytokine production. This Program seeks to identify context-dependent events that are critical for immune function in specific inflammatory settings. To achieve this goal, the Program has developed innovative tools for intra-vital imaging of inflamed tissue. The major objective of Core A is to provide administrative and scientific oversight to the individual projects and Cores. Its scientific mission is to promote and create forums for scientific exchange within the Projects, between groups at the Institution and the broader international scientific community. Administratively, monthly meetings will be scheduled between Dr Fowell and the administrative staff to ensure good communication and safety compliance and monthly meetings will be organized with project leaders and the accountant to discuss individual accounts. To promote scientific exchange, monthly research-in-progress meetings will be held to discuss conceptual and technical advances in individual projects that may impact the Program as a whole. An annual “Immune Imaging” symposium will be organized from within this Core and has been the highlight of the previous funding cycle with 4 Symposia held attracting leaders in the field as speakers and a strong local and national attendance. We see this Symposium as a way to nucleate scientist across the country to discuss challenges in the field and to exchange ideas on innovative technology that will facilitate the in situ study of immunity, infectious or autoimmune, in inflamed tissues.

项目概要/摘要-行政核心 目前，我们在炎症组织中操纵免疫功能的能力受到缺乏基本免疫原性的限制。 了解细胞在炎症环境中的功能。缓解组织炎症的当前方法 集中于一般免疫抑制或一般阻断白细胞进入组织。在原则上， 这些策略可以预防疾病，但由于传染病的增加而导致的并发症已经消失， 热情因此，治疗需要变得更具炎症特异性，通过预防炎症， 募集特定类型的T细胞（阻断T细胞的过敏反应，但留下白细胞的流入 用于在相同组织中完整地清除细菌）或通过阻断用于特异性细胞因子产生的信号。这 该计划旨在确定对特定免疫功能至关重要的环境依赖性事件， 煽动性的环境为了实现这一目标，该计划开发了用于活体成像的创新工具 发炎的组织核心A的主要目标是为国家和国际组织提供行政和科学监督， 个别项目和核心。其科学使命是促进和创造科学交流论坛 在项目内部，在研究所和更广泛的国际科学界的团体之间。 在行政方面，Fowell博士和行政人员之间将安排每月会议，以确保 与项目负责人进行良好的沟通和安全合规，并组织月度会议， 会计讨论个人账户。为了促进科学交流，每月 将举行会议，讨论个别项目的概念和技术进步， 整个方案。每年的“免疫成像”研讨会将在该核心内组织， 是上一个供资周期的亮点，举办了4次专题讨论会，吸引了该领域的领导人作为发言人 以及全国各地的观众我们认为这次研讨会是一种方式，以核科学家在整个 我们将与各国讨论这一领域的挑战，并就创新技术交换意见， 炎症组织中感染性或自身免疫性免疫的原位研究。