Supplement to Communication between Networks: Context, Inhibition, and Neuromodulation
网络间通信的补充:情境、抑制和神经调节
基本信息
- 批准号:10478350
- 负责人:
- 金额:$ 16.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAnimalsAreaAttentionAuditoryBehavioralBrainBrain DiseasesBrain regionCalciumCerebral cortexCommunicationComplexDiseaseDissectionFoundationsFutureGoalsHeadImageLabelMonitorMusPerceptionPerformanceProcessRoleRunningSchizophreniaSensorySignal TransductionSocietiesSourceStimulusStreamSystemaddictionauditory stimulusautism spectrum disorderbehavioral responsecell typecognitive processexcitatory neuronexperimental studyflexibilityinformation processinginhibitory neuronneuroregulationoperationoptogeneticsrecruitrelating to nervous systemresponsesensory stimulussignal processingtooltransmission processtreadmilltwo-photonvirtual realityvisual stimulus
项目摘要
Project Summary
The brain is often bombarded by streams of information from multiple sources simultaneously. In real world
situations, rapidly changing contexts can shift the meaning of a sensory stimulus, requiring an animal to
change its response to a given stimulus on the fly. The ability to flexibly and appropriately adjust behavioral
responses in changing contexts is critical not only for survival, but also to thrive in society. Indeed, disruptions
in this ability characterize many brain disorders. The goal of our lab is to understand the mechanisms that
underlie the flexibility of information processing in cortical circuits, focusing on how inhibitory neurons gate the
flow of information between sensory and association regions in a context-dependent manner. Head-fixed mice
voluntarily running on a spherical treadmill will be rapidly shifted between behavioral contexts within single
sessions. These contexts will include spontaneous (no experimenter-controlled sensory stimulation), passive
delivery of visual and auditory stimuli, and active performance of auditory perceptual tasks in virtual reality. In
each of these contexts, two-photon imaging of calcium activity will be used to monitor the responses of
hundreds of genetically labeled inhibitory and excitatory neurons simultaneously. In some experiments,
optogenetics will be used to activate specific incoming projections to the imaged region, or to inactivate specific
cell types. These tools will be combined in three main projects. In the first project, the inhibitory mechanisms
gating the flow of information between cortical regions will be dissected, to determine whether canonical rules
define inhibitory operations across cortex, or if local specializations allow greater flexibility at different
hierarchical levels of the cerebral cortex. In the second project, the roles of inhibitory neurons in setting
network dynamics will be determined, and the consequences of shifting network dynamics on signal
processing will be defined. In the third project, neuromodulatory recruitment of inhibitory circuits across the
cortical hierarchy will be described, to determine how shifts in brain state affect information processing. To
understand the neural underpinnings of perception, attention, and behavioral flexibility, it is critical to study the
interaction between brain areas, rather than to focus on single brain regions in isolation. The experiments
proposed here will use new tools to answer fundamental questions about how local circuits interact to process
information, toward the goal of understanding how the distributed cortical network gives rise to cognitive
processes such as attention and perception.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Caroline Anne Runyan其他文献
Caroline Anne Runyan的其他文献
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{{ truncateString('Caroline Anne Runyan', 18)}}的其他基金
The role of inhibition in the mapping and plasticity of representations in V1
抑制在 V1 表征的映射和可塑性中的作用
- 批准号:
8120469 - 财政年份:2010
- 资助金额:
$ 16.6万 - 项目类别:
The role of inhibition in the mapping and plasticity of representations in V1
抑制在 V1 表征的映射和可塑性中的作用
- 批准号:
8001284 - 财政年份:2010
- 资助金额:
$ 16.6万 - 项目类别:
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