Peer-driven intervention promoting pre-exposure prophylaxis uptake among African American and Hispanic/Latino men who have sex with men

同伴驱动的干预促进非裔美国人和男男性行为西班牙裔/拉丁裔男性接受暴露前预防

• 批准号: 10478083
• 负责人: Jun Tao
• 金额: $ 16.92万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10478083
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adherence; African American; African American population; Awareness; Benchmarking; Bisexual; Caring; Centers for Disease Control and Prevention (U.S.); Characteristics; Clinical; Communicable Diseases; Control Groups; Data; Deep South; Diagnosis; Education; Effectiveness; Eligibility Determination; Enrollment; Environment; Epidemiologist; Funding; Gays; Goals; HIV; HIV Infections; HIV diagnosis; HIV risk; Hispanic; Incidence; Individual; Insurance; Intervention; Interview; Knowledge; Latino; Location; Medicine; Mentored Research Scientist Development Award; Mentors; Methodology; Methods; Mississippi; Modeling; Outcome; Participant; Pathway Analysis; Population; Population Sizes; Populations at Risk; Provider; Public Health Schools; Randomized Controlled Trials; Recommendation; Research; Research Personnel; Research Priority; Respondent; Rhode Island; Risk; Sampling; Site; Social Network; Study models; Training; Treatment Efficacy; United States; United States National Institutes of Health; Universities; Ursidae Family; Visit; Work; base; burden of illness; career; comparison group; condoms; cost; cost effective; disparity reduction; efficacy testing; group intervention; health care availability; health disparity; high risk; implementation efforts; improved; indexing; interest; mathematical model; member; men who have sex with men; novel; novel strategies; open label; outreach; peer; pre-exposure prophylaxis; prevent; primary outcome; recruit; screening; social organization; social stigma; success; transmission process; uptake

PROJECT SUMMARY The proposed K01 application will catalyze Dr. Tao’s independent career as an infectious disease epidemiologist with expertise in HIV prevention and pre-exposure prophylaxis (PrEP), qualitative interviews, respondent driven sampling (RDS), social network analysis (SNA), and mathematic modeling in addressing health disparities in access to PrEP care (Career goals). The PI and her co-primary mentor are based in the Department of Medicine at Brown University, and will also work closely with co-primary mentor and co-mentors at the School of Public Health at Brown University, at Rutgers University, and at the University of Mississippi. Together, this team of mentors and institutional environment will allow the junior PI a high chance of success in completing the research goals and becoming an NIH-funded independent investigator. African American (AA) and Hispanic/Latino (H/L) men who have sex with men (MSM) bear a disproportionate HIV disease burden in the United States (US). PrEP is highly effective in reducing HIV acquisition, but PrEP uptake among AA and H/L MSM has been slow compared to White MSM. Effective and novel interventions are needed to promote PrEP uptake in these populations to reduce HIV incidence. A peer-driven intervention (PDI) is based on RDS methodology and has been demonstrated to be a highly effective, culturally appropriate, and low-cost approach to engage hard-to-reach populations in HIV prevention. The effect of a PDI on PrEP uptake, especially among AA and H/L MSM, is unknown. In this proposed study, we will conduct 30 individual interviews (15 AA and 15 H/L MSM) to explore facilitators and barriers to PrEP uptake and determine components of an effective PDI among AA and H/L MSM (Specific Aim[SA]1). The effect of a PDI on PrEP uptake will be assessed and compared to a group of AA and H/L MSM who will be recruited by venue-based sampling (N=200, 50 AA and 50 H/L MSM in each group) (SA2). Using data from the SA2, we will perform microsimulations in the context of an agent-based model to evaluate the impact of a PDI on PrEP uptake and HIV incidence at the population level (SA3).

项目摘要 拟议的K01申请将催化陶博士作为一种传染病的独立职业 具有艾滋病毒预防和暴露前预防的专业知识的流行病学家（PREP），定性访谈， 负责驱动采样（RDS），社交网络分析（SNA）和数学建模 获得预科护理（职业目标）的健康差异。 PI和她的联合主导导师位于 布朗大学医学系，还将与联合学员兼联合主管密切合作 在布朗大学，罗格斯大学和密西西比大学的公共卫生学院。 这组导师和机构环境团队将使大三的PI很有机会成功 完成研究目标并成为NIH资助的独立研究者。非裔美国人（AA） 与男性发生性关系（MSM）的西班牙裔/拉丁裔（H/L）男性患有不成比例的HIV疾病伯恩 美国（美国）。 PREP在减少艾滋病毒的收购方面非常有效，但AA和 与白色MSM相比，H/L MSM速度很慢。需要有效和新颖的干预措施来促进 这些人群的预先吸收以减少艾滋病毒的发病率。同行驱动的干预（PDI）基于RDS 方法论，已被证明是一种非常有效的，文化上适当的和低成本的 参与艾滋病毒预防的困难人群的方法。 PDI对摄取的影响， 特别是在AA和H/L MSM中，未知。在这项拟议的研究中，我们将进行30个人 访谈（15 aa和15 h/l MSM）探索促进者和障碍以进行准备并确定 AA和H/L MSM之间有效PDI的组件（特定AIM [SA] 1）。 PDI对准备的影响 将评估吸收并将其与一组AA和H/L MSM进行比较 采样（每组中n = 200、50 aa和50 h/l msm）（SA2）。使用来自SA2的数据，我们将执行 在基于代理的模型的背景下，微观模拟，以评估PDI对PREP吸收和的影响 艾滋病毒在人群层面（SA3）。