Peer-driven intervention promoting pre-exposure prophylaxis uptake among African American and Hispanic/Latino men who have sex with men

同伴驱动的干预促进非裔美国人和男男性行为西班牙裔/拉丁裔男性接受暴露前预防

• 批准号: 10478083
• 负责人: Jun Tao
• 金额: $ 16.92万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10478083
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adherence; African American; African American population; Awareness; Benchmarking; Bisexual; Caring; Centers for Disease Control and Prevention (U.S.); Characteristics; Clinical; Communicable Diseases; Control Groups; Data; Deep South; Diagnosis; Education; Effectiveness; Eligibility Determination; Enrollment; Environment; Epidemiologist; Funding; Gays; Goals; HIV; HIV Infections; HIV diagnosis; HIV risk; Hispanic; Incidence; Individual; Insurance; Intervention; Interview; Knowledge; Latino; Location; Medicine; Mentored Research Scientist Development Award; Mentors; Methodology; Methods; Mississippi; Modeling; Outcome; Participant; Pathway Analysis; Population; Population Sizes; Populations at Risk; Provider; Public Health Schools; Randomized Controlled Trials; Recommendation; Research; Research Personnel; Research Priority; Respondent; Rhode Island; Risk; Sampling; Site; Social Network; Study models; Training; Treatment Efficacy; United States; United States National Institutes of Health; Universities; Ursidae Family; Visit; Work; base; burden of illness; career; comparison group; condoms; cost; cost effective; disparity reduction; efficacy testing; group intervention; health care availability; health disparity; high risk; implementation efforts; improved; indexing; interest; mathematical model; member; men who have sex with men; novel; novel strategies; open label; outreach; peer; pre-exposure prophylaxis; prevent; primary outcome; recruit; screening; social organization; social stigma; success; transmission process; uptake

PROJECT SUMMARY The proposed K01 application will catalyze Dr. Tao’s independent career as an infectious disease epidemiologist with expertise in HIV prevention and pre-exposure prophylaxis (PrEP), qualitative interviews, respondent driven sampling (RDS), social network analysis (SNA), and mathematic modeling in addressing health disparities in access to PrEP care (Career goals). The PI and her co-primary mentor are based in the Department of Medicine at Brown University, and will also work closely with co-primary mentor and co-mentors at the School of Public Health at Brown University, at Rutgers University, and at the University of Mississippi. Together, this team of mentors and institutional environment will allow the junior PI a high chance of success in completing the research goals and becoming an NIH-funded independent investigator. African American (AA) and Hispanic/Latino (H/L) men who have sex with men (MSM) bear a disproportionate HIV disease burden in the United States (US). PrEP is highly effective in reducing HIV acquisition, but PrEP uptake among AA and H/L MSM has been slow compared to White MSM. Effective and novel interventions are needed to promote PrEP uptake in these populations to reduce HIV incidence. A peer-driven intervention (PDI) is based on RDS methodology and has been demonstrated to be a highly effective, culturally appropriate, and low-cost approach to engage hard-to-reach populations in HIV prevention. The effect of a PDI on PrEP uptake, especially among AA and H/L MSM, is unknown. In this proposed study, we will conduct 30 individual interviews (15 AA and 15 H/L MSM) to explore facilitators and barriers to PrEP uptake and determine components of an effective PDI among AA and H/L MSM (Specific Aim[SA]1). The effect of a PDI on PrEP uptake will be assessed and compared to a group of AA and H/L MSM who will be recruited by venue-based sampling (N=200, 50 AA and 50 H/L MSM in each group) (SA2). Using data from the SA2, we will perform microsimulations in the context of an agent-based model to evaluate the impact of a PDI on PrEP uptake and HIV incidence at the population level (SA3).

项目总结 拟议的K01申请将催化陶医生作为传染病的独立职业生涯 具有艾滋病毒预防和暴露前预防(PrEP)专业知识的流行病学家，定性访谈， 受访者驱动抽样(RDS)、社交网络分析(SNA)和解决方案中的数学建模 在获得PrEP护理(职业目标)方面的健康差距。PI和她的联合初选导师的总部设在 布朗大学医学系，并将与共同小学导师和共同导师密切合作 布朗大学公共卫生学院、罗格斯大学和密西西比大学。 这支导师团队和机构环境将使初级PI有很高的成功机会 完成研究目标，成为美国国立卫生研究院资助的独立调查员。非裔美国人(AA) 和西班牙裔/拉丁裔(H/L)男男性行为者(MSM)在#年承担不成比例的艾滋病毒疾病负担 美国(US)。PREP在减少HIV感染方面非常有效，但AA和 与白色MSM相比，H/L MSM一直很慢。需要有效和新颖的干预措施来促进 在这些人群中摄取PREP以降低艾滋病毒发病率。同行驱动的干预(PDI)基于RDS 方法，并已被证明是一种高效、适合文化和低成本的 让难以接触到的人群参与艾滋病毒预防的方法。PDI对PrEP摄取的影响， 特别是在AA和H/L MSM中，尚不为人所知。在这项拟议的研究中，我们将进行30名个人 访谈(15名AA和15名H/L男男性接触者)，以探索促进者和阻碍PrEP吸收的障碍并确定 AA和H/L男男性接触者有效PDI的组成(特定目标[SA]1)PDI对PrEP的影响 将评估一组AA和H/L MSM，并将其与场馆招聘的MSM进行比较 抽样(N=200例，AA组50例，H/L组50例)(SA2)。使用来自SA2的数据，我们将执行 在基于试剂的模型的背景下评估PDI对PrEP摄取和 艾滋病毒在人口层面的发病率(SA3)。