Peer-driven intervention promoting pre-exposure prophylaxis uptake among African American and Hispanic/Latino men who have sex with men

同伴驱动的干预促进非裔美国人和男男性行为西班牙裔/拉丁裔男性接受暴露前预防

• 批准号: 10241529
• 负责人: Jun Tao
• 金额: $ 16.92万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10241529
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adherence; African American; Awareness; Benchmarking; Bisexual; Caring; Centers for Disease Control and Prevention (U.S.); Characteristics; Clinical; Communicable Diseases; Control Groups; Data; Deep South; Diagnosis; Education; Effectiveness; Eligibility Determination; Enrollment; Environment; Epidemiologist; Funding; Gays; Goals; HIV; HIV Infections; HIV diagnosis; HIV risk; Hispanics; Incidence; Individual; Insurance; Intervention; Interview; Knowledge; Latino; Location; Medicine; Mentored Research Scientist Development Award; Mentors; Methodology; Methods; Mississippi; Modeling; Outcome; Participant; Pathway Analysis; Population; Population Sizes; Populations at Risk; Provider; Public Health Schools; Randomized Controlled Trials; Recommendation; Research; Research Personnel; Research Priority; Respondent; Rhode Island; Risk; Sampling; Site; Social Network; Study models; Training; Treatment Efficacy; United States; United States National Institutes of Health; Universities; Ursidae Family; Visit; Work; base; burden of illness; career; comparison group; condoms; cost; cost effective; disparity reduction; efficacy testing; group intervention; health care availability; health disparity; high risk; implementation efforts; improved; indexing; interest; mathematical model; member; men who have sex with men; novel; novel strategies; open label; outreach; peer; pre-exposure prophylaxis; prevent; primary outcome; recruit; screening; social organization; social stigma; success; transmission process; uptake

PROJECT SUMMARY The proposed K01 application will catalyze Dr. Tao’s independent career as an infectious disease epidemiologist with expertise in HIV prevention and pre-exposure prophylaxis (PrEP), qualitative interviews, respondent driven sampling (RDS), social network analysis (SNA), and mathematic modeling in addressing health disparities in access to PrEP care (Career goals). The PI and her co-primary mentor are based in the Department of Medicine at Brown University, and will also work closely with co-primary mentor and co-mentors at the School of Public Health at Brown University, at Rutgers University, and at the University of Mississippi. Together, this team of mentors and institutional environment will allow the junior PI a high chance of success in completing the research goals and becoming an NIH-funded independent investigator. African American (AA) and Hispanic/Latino (H/L) men who have sex with men (MSM) bear a disproportionate HIV disease burden in the United States (US). PrEP is highly effective in reducing HIV acquisition, but PrEP uptake among AA and H/L MSM has been slow compared to White MSM. Effective and novel interventions are needed to promote PrEP uptake in these populations to reduce HIV incidence. A peer-driven intervention (PDI) is based on RDS methodology and has been demonstrated to be a highly effective, culturally appropriate, and low-cost approach to engage hard-to-reach populations in HIV prevention. The effect of a PDI on PrEP uptake, especially among AA and H/L MSM, is unknown. In this proposed study, we will conduct 30 individual interviews (15 AA and 15 H/L MSM) to explore facilitators and barriers to PrEP uptake and determine components of an effective PDI among AA and H/L MSM (Specific Aim[SA]1). The effect of a PDI on PrEP uptake will be assessed and compared to a group of AA and H/L MSM who will be recruited by venue-based sampling (N=200, 50 AA and 50 H/L MSM in each group) (SA2). Using data from the SA2, we will perform microsimulations in the context of an agent-based model to evaluate the impact of a PDI on PrEP uptake and HIV incidence at the population level (SA3).

项目总结