NEW TECHNOLOGIES FOR AFRICAN SWINE FEVER VACCINES

VAX 4ASF旨在开发一个最先进的平台，以生产针对家猪和野猪的高效安全的ASFV疫苗。这些候选疫苗将基于创新和强大的疫苗平台进行设计，该平台将确保对欧洲不同的ASFV变体的免疫保护，同时避免使用传统减毒活疫苗平台产生的安全性问题。候选疫苗将有效地诱导具有足够的适应性免疫的先天免疫应答。此外，诱导的免疫力将允许区分接种疫苗和受感染的动物，这将通过在项目范围内开发的补充DIVA测试进行监测。鉴于ASFV基因组的复杂性以及对ASFV免疫应答机制的了解仍然不完整，VAX 4ASF旨在进一步了解病毒的分子机制以及它如何与宿主相互作用。开发的平台可用于基于这种新生成的知识引入新的突变，这将允许提高疫苗原型的有效性和交叉保护。VAX 4ASF将使用不同的数学模型提供新的病毒流行病学模型和控制策略，从而更好地了解ASFV在野外-家庭界面的传播。通过这种方式，将产生ASFV控制和管理的创新政策和战略，以确保通过关键利益相关者作为项目合作伙伴（农民，野生董事会管理人员，兽医，猎人，政策制定者.）的持续参与产生显著影响。从而对动物健康和全球经济产生深远影响。该项目依赖于创新动物健康疫苗的领先开发商与国际ASF领域最高专家之间的坚实合作轨迹，包括来自欧洲，美国和肯尼亚的合作伙伴，以实现这一挑战。

VAX4ASF aims to develop a state-of-the-art platform to produce highly effective and safe vaccines against ASFV targeted for both domestic pigs and wild boars. These vaccine candidates will be designed based on an innovative and robust vaccine platform that will guarantee immune protection against the different circulating ASFV variantsin Europe, while avoiding the safety concerns arisen with the use of traditional live attenuated vaccine platforms. Vaccine candidates will effectively induce innate immune response with the adequate adaptive immunity. Moreover, the immunity induced will allow discrimination between vaccinated and infected animals, which will be monitored by complementary DIVA tests developed under the scope of the project. Given the complexity of ASFV genome and the still incomplete knowledge of the mechanisms involved in immune response to ASFV, VAX4ASF aims to further understand the molecular mechanisms of the virus and how it interacts with the host. The developed platform can be used to introduce new mutations based in this new generated knowledge which will allow to improve the efficacy and cross-protection of the vaccine prototypes. VAX4ASF will provide new virus epidemiology models and control strategies using different mathematical models, leading to a better understanding of the ASFV transmission at the wild-domestic interface. In this way, innovative policies and strategies for ASFV control and management will be generated to ensure an outstanding impact through the continuous involvement of key stakeholders as project partners (farmers, wild board managers, veterinaries, hunters, policy makers...), leading to a profound effect in animal health and worldwide economy. The project relies on a solid collaboration trajectory between leading developers of innovative Animal Health vaccines and the highest experts in ASF field at international level, including partners from Europe, USA, and Kenya for the achievement of this challenge.